New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages

The insertion Sequence IS6110, only present in the pathogens of the Mycobacterium tuberculosis Complex (MTBC), has been the gold-standard epidemiological marker for TB for more than 25 years, but biological implications of IS6110 transposition during MTBC adaptation to humans remain elusive. By stud...

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Veröffentlicht in:	PLoS genetics 2018-04, Vol.14 (4), p.e1007282-e1007282
Hauptverfasser:	Gonzalo-Asensio, Jesús, Pérez, Irene, Aguiló, Nacho, Uranga, Santiago, Picó, Ana, Lampreave, Carlos, Cebollada, Alberto, Otal, Isabel, Samper, Sofía, Martín, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Biology and Life Sciences Chromosomes Clinical isolates Diagnosis Distribution DNA insertion elements Drug resistance Epidemiology Genetic aspects Genomes Growth conditions Health aspects HIV Human immunodeficiency virus Infections Laboratories Medicine and Health Sciences Mutation Mycobacterium tuberculosis Post-transcription Research and Analysis Methods Ribonucleic acid RNA rRNA Software Transposase Transposition Transposons Tuberculosis
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