Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo

Wnt signaling provides a paradigm for cell-cell signals that regulate embryonic development and stem cell homeostasis and are inappropriately activated in cancers. The tumor suppressors APC and Axin form the core of the multiprotein destruction complex, which targets the Wnt-effector beta-catenin fo...

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Veröffentlicht in:	PLoS genetics 2018-04, Vol.14 (4), p.e1007339-e1007339
Hauptverfasser:	Schaefer, Kristina N, Bonello, Teresa T, Zhang, Shiping, Williams, Clara E, Roberts, David M, McKay, Daniel J, Peifer, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous polyposis coli Animals Animals, Genetically Modified Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - chemistry Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics Apc1 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism Armadillo Domain Proteins - chemistry Armadillo Domain Proteins - genetics Armadillo Domain Proteins - metabolism Axin Protein - chemistry Axin Protein - genetics Axin Protein - metabolism Axin Signaling Complex - chemistry Axin Signaling Complex - genetics Axin Signaling Complex - metabolism Binding proteins Biology and Life Sciences Cancer Cell Line Colorectal cancer Curricula Dishevelled protein Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Embryogenesis Embryos Funding Genes Genetic disorders Genetic engineering Glycogen Glycogen synthase Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Health aspects Homeostasis Insects Kinases Localization Medicine and Health Sciences Microscopy Molecular biology Multiprotein Complexes - chemistry Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Phosphorylation Polymerization Polyps Proteins Proteolysis Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Regulation Research and Analysis Methods RNA, Messenger - genetics RNA, Messenger - metabolism Stem cells Stoichiometry Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Tumor Suppressor Proteins - chemistry Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitination Wnt protein Wnt proteins Wnt Signaling Pathway Wnt1 Protein - genetics Wnt1 Protein - metabolism β-Catenin
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