Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition
Zinc is an essential micronutrient for all living organisms and is involved in a plethora of processes including growth and development, and immunity. However, it is unknown if there is a common genetic and molecular basis underlying multiple facets of zinc function. Here we used natural variation i...
Gespeichert in:
| Veröffentlicht in: | PLoS genetics 2018-04, Vol.14 (4), p.e1007304-e1007304 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e1007304 |
|---|---|
| container_issue | 4 |
| container_start_page | e1007304 |
| container_title | PLoS genetics |
| container_volume | 14 |
| creator | Bouain, Nadia Satbhai, Santosh B Korte, Arthur Saenchai, Chorpet Desbrosses, Guilhem Berthomieu, Pierre Busch, Wolfgang Rouached, Hatem |
| description | Zinc is an essential micronutrient for all living organisms and is involved in a plethora of processes including growth and development, and immunity. However, it is unknown if there is a common genetic and molecular basis underlying multiple facets of zinc function. Here we used natural variation in Arabidopsis thaliana to study the role of zinc in regulating growth. We identify allelic variation of the systemic immunity gene AZI1 as a key for determining root growth responses to low zinc conditions. We further demonstrate that this gene is important for modulating primary root length depending on the zinc and defence status. Finally, we show that the interaction of the immunity signal azelaic acid and zinc level to regulate root growth is conserved in rice. This work demonstrates that there is a common genetic and molecular basis for multiple zinc dependent processes and that nutrient cues can determine the balance of growth and immune responses in plants. |
| doi_str_mv | 10.1371/journal.pgen.1007304 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2056434042</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A536809363</galeid><doaj_id>oai_doaj_org_article_ec2e7ce725fa4af1894755b960f51c96</doaj_id><sourcerecordid>A536809363</sourcerecordid><originalsourceid>FETCH-LOGICAL-c826t-dd7ef33134cc8ed4ea9de2eef5286892e68af29eeb39bdaf0390099d4c4b39f63</originalsourceid><addsrcrecordid>eNqVk1uL1DAUx4so7rr6DUQLgrgPM-bW24swLOoODLvg7UGQkElP2iyZZkzS8fLpTZ3uMl32QelDy-nv_E_O_-QkyVOM5pgW-PWV7V0nzHzbQDfHCBUUsXvJMc4yOisYYvcPvo-SR95fIUSzsioeJkekylGZ5dlx8u1ChN4JkwpjwGiZ7oTTImjbpValoYV08XWJ01gDUmm74KzxqbM2pI2zP0Kb9l0NLv2tOzkzeqOD7poBrPWg8Th5oITx8GR8nySf3739dHY-W12-X54tVjNZkjzM6roARSmmTMoSagaiqoEAqIyUeVkRyEuhSAWwptW6FgrRCqGqqplkMaJyepI83-tujfV8dMZzgrKc0dg_icRyT9RWXPGt0xvhfnErNP8bsK7hwgUtDXCQBAoJBcmUYELhsmJFlq2jZSrDshqqvRmr9esN1BKiLcJMRKd_Ot3yxu744D6iRRQ43Qu0t9LOFys-xBAu4sFLtsORfTUWc_Z7Dz7wjfYSjBEd2H7okWBKSJ6jiL64hd7txEg1IjarO2XjGeUgyhcZzUtU0ZxGan4HFZ8aNjrOF5SO8UnC6SRhuCzwMzSi954vP374D_bi39nLL1P25QHbgjCh9db0w1X0U5DtQems9w7UzRQw4sN2XTvHh-3i43bFtGeHg79Jul4n-gci7B4l</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2056434042</pqid></control><display><type>article</type><title>Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Bouain, Nadia ; Satbhai, Santosh B ; Korte, Arthur ; Saenchai, Chorpet ; Desbrosses, Guilhem ; Berthomieu, Pierre ; Busch, Wolfgang ; Rouached, Hatem</creator><creatorcontrib>Bouain, Nadia ; Satbhai, Santosh B ; Korte, Arthur ; Saenchai, Chorpet ; Desbrosses, Guilhem ; Berthomieu, Pierre ; Busch, Wolfgang ; Rouached, Hatem</creatorcontrib><description>Zinc is an essential micronutrient for all living organisms and is involved in a plethora of processes including growth and development, and immunity. However, it is unknown if there is a common genetic and molecular basis underlying multiple facets of zinc function. Here we used natural variation in Arabidopsis thaliana to study the role of zinc in regulating growth. We identify allelic variation of the systemic immunity gene AZI1 as a key for determining root growth responses to low zinc conditions. We further demonstrate that this gene is important for modulating primary root length depending on the zinc and defence status. Finally, we show that the interaction of the immunity signal azelaic acid and zinc level to regulate root growth is conserved in rice. This work demonstrates that there is a common genetic and molecular basis for multiple zinc dependent processes and that nutrient cues can determine the balance of growth and immune responses in plants.</description><identifier>ISSN: 1553-7404</identifier><identifier>ISSN: 1553-7390</identifier><identifier>EISSN: 1553-7404</identifier><identifier>DOI: 10.1371/journal.pgen.1007304</identifier><identifier>PMID: 29608565</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Alleles ; Arabidopsis thaliana ; Biology and Life Sciences ; Cellular biology ; Gene expression ; Genetic aspects ; Genetic variation ; Genetics ; Genomes ; Health aspects ; Immune response ; Laboratories ; Life Sciences ; Mendel, Gregor (1822-84) ; Physical Sciences ; Physiology ; Plant resistance ; Plant sciences ; Proteins ; Research and Analysis Methods ; Rice ; Studies ; Vegetal Biology ; Zinc ; Zinc (Nutrient)</subject><ispartof>PLoS genetics, 2018-04, Vol.14 (4), p.e1007304-e1007304</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: gene controls root growth under zinc-limiting condition. PLoS Genet 14(4): e1007304. https://doi.org/10.1371/journal.pgen.1007304</rights><rights>Attribution</rights><rights>2018 Bouain et al 2018 Bouain et al</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: gene controls root growth under zinc-limiting condition. PLoS Genet 14(4): e1007304. https://doi.org/10.1371/journal.pgen.1007304</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c826t-dd7ef33134cc8ed4ea9de2eef5286892e68af29eeb39bdaf0390099d4c4b39f63</citedby><cites>FETCH-LOGICAL-c826t-dd7ef33134cc8ed4ea9de2eef5286892e68af29eeb39bdaf0390099d4c4b39f63</cites><orcidid>0000-0002-2770-656X ; 0000-0003-0831-1463 ; 0000-0003-2042-7290 ; 0000-0002-7751-0477 ; 0000-0003-3358-2417 ; 0000-0003-3965-9972</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897037/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897037/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29608565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01764384$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouain, Nadia</creatorcontrib><creatorcontrib>Satbhai, Santosh B</creatorcontrib><creatorcontrib>Korte, Arthur</creatorcontrib><creatorcontrib>Saenchai, Chorpet</creatorcontrib><creatorcontrib>Desbrosses, Guilhem</creatorcontrib><creatorcontrib>Berthomieu, Pierre</creatorcontrib><creatorcontrib>Busch, Wolfgang</creatorcontrib><creatorcontrib>Rouached, Hatem</creatorcontrib><title>Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition</title><title>PLoS genetics</title><addtitle>PLoS Genet</addtitle><description>Zinc is an essential micronutrient for all living organisms and is involved in a plethora of processes including growth and development, and immunity. However, it is unknown if there is a common genetic and molecular basis underlying multiple facets of zinc function. Here we used natural variation in Arabidopsis thaliana to study the role of zinc in regulating growth. We identify allelic variation of the systemic immunity gene AZI1 as a key for determining root growth responses to low zinc conditions. We further demonstrate that this gene is important for modulating primary root length depending on the zinc and defence status. Finally, we show that the interaction of the immunity signal azelaic acid and zinc level to regulate root growth is conserved in rice. This work demonstrates that there is a common genetic and molecular basis for multiple zinc dependent processes and that nutrient cues can determine the balance of growth and immune responses in plants.</description><subject>Alleles</subject><subject>Arabidopsis thaliana</subject><subject>Biology and Life Sciences</subject><subject>Cellular biology</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genetic variation</subject><subject>Genetics</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Immune response</subject><subject>Laboratories</subject><subject>Life Sciences</subject><subject>Mendel, Gregor (1822-84)</subject><subject>Physical Sciences</subject><subject>Physiology</subject><subject>Plant resistance</subject><subject>Plant sciences</subject><subject>Proteins</subject><subject>Research and Analysis Methods</subject><subject>Rice</subject><subject>Studies</subject><subject>Vegetal Biology</subject><subject>Zinc</subject><subject>Zinc (Nutrient)</subject><issn>1553-7404</issn><issn>1553-7390</issn><issn>1553-7404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqVk1uL1DAUx4so7rr6DUQLgrgPM-bW24swLOoODLvg7UGQkElP2iyZZkzS8fLpTZ3uMl32QelDy-nv_E_O_-QkyVOM5pgW-PWV7V0nzHzbQDfHCBUUsXvJMc4yOisYYvcPvo-SR95fIUSzsioeJkekylGZ5dlx8u1ChN4JkwpjwGiZ7oTTImjbpValoYV08XWJ01gDUmm74KzxqbM2pI2zP0Kb9l0NLv2tOzkzeqOD7poBrPWg8Th5oITx8GR8nySf3739dHY-W12-X54tVjNZkjzM6roARSmmTMoSagaiqoEAqIyUeVkRyEuhSAWwptW6FgrRCqGqqplkMaJyepI83-tujfV8dMZzgrKc0dg_icRyT9RWXPGt0xvhfnErNP8bsK7hwgUtDXCQBAoJBcmUYELhsmJFlq2jZSrDshqqvRmr9esN1BKiLcJMRKd_Ot3yxu744D6iRRQ43Qu0t9LOFys-xBAu4sFLtsORfTUWc_Z7Dz7wjfYSjBEd2H7okWBKSJ6jiL64hd7txEg1IjarO2XjGeUgyhcZzUtU0ZxGan4HFZ8aNjrOF5SO8UnC6SRhuCzwMzSi954vP374D_bi39nLL1P25QHbgjCh9db0w1X0U5DtQems9w7UzRQw4sN2XTvHh-3i43bFtGeHg79Jul4n-gci7B4l</recordid><startdate>20180402</startdate><enddate>20180402</enddate><creator>Bouain, Nadia</creator><creator>Satbhai, Santosh B</creator><creator>Korte, Arthur</creator><creator>Saenchai, Chorpet</creator><creator>Desbrosses, Guilhem</creator><creator>Berthomieu, Pierre</creator><creator>Busch, Wolfgang</creator><creator>Rouached, Hatem</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-2770-656X</orcidid><orcidid>https://orcid.org/0000-0003-0831-1463</orcidid><orcidid>https://orcid.org/0000-0003-2042-7290</orcidid><orcidid>https://orcid.org/0000-0002-7751-0477</orcidid><orcidid>https://orcid.org/0000-0003-3358-2417</orcidid><orcidid>https://orcid.org/0000-0003-3965-9972</orcidid></search><sort><creationdate>20180402</creationdate><title>Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition</title><author>Bouain, Nadia ; Satbhai, Santosh B ; Korte, Arthur ; Saenchai, Chorpet ; Desbrosses, Guilhem ; Berthomieu, Pierre ; Busch, Wolfgang ; Rouached, Hatem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c826t-dd7ef33134cc8ed4ea9de2eef5286892e68af29eeb39bdaf0390099d4c4b39f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alleles</topic><topic>Arabidopsis thaliana</topic><topic>Biology and Life Sciences</topic><topic>Cellular biology</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genetic variation</topic><topic>Genetics</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Immune response</topic><topic>Laboratories</topic><topic>Life Sciences</topic><topic>Mendel, Gregor (1822-84)</topic><topic>Physical Sciences</topic><topic>Physiology</topic><topic>Plant resistance</topic><topic>Plant sciences</topic><topic>Proteins</topic><topic>Research and Analysis Methods</topic><topic>Rice</topic><topic>Studies</topic><topic>Vegetal Biology</topic><topic>Zinc</topic><topic>Zinc (Nutrient)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouain, Nadia</creatorcontrib><creatorcontrib>Satbhai, Santosh B</creatorcontrib><creatorcontrib>Korte, Arthur</creatorcontrib><creatorcontrib>Saenchai, Chorpet</creatorcontrib><creatorcontrib>Desbrosses, Guilhem</creatorcontrib><creatorcontrib>Berthomieu, Pierre</creatorcontrib><creatorcontrib>Busch, Wolfgang</creatorcontrib><creatorcontrib>Rouached, Hatem</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouain, Nadia</au><au>Satbhai, Santosh B</au><au>Korte, Arthur</au><au>Saenchai, Chorpet</au><au>Desbrosses, Guilhem</au><au>Berthomieu, Pierre</au><au>Busch, Wolfgang</au><au>Rouached, Hatem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition</atitle><jtitle>PLoS genetics</jtitle><addtitle>PLoS Genet</addtitle><date>2018-04-02</date><risdate>2018</risdate><volume>14</volume><issue>4</issue><spage>e1007304</spage><epage>e1007304</epage><pages>e1007304-e1007304</pages><issn>1553-7404</issn><issn>1553-7390</issn><eissn>1553-7404</eissn><abstract>Zinc is an essential micronutrient for all living organisms and is involved in a plethora of processes including growth and development, and immunity. However, it is unknown if there is a common genetic and molecular basis underlying multiple facets of zinc function. Here we used natural variation in Arabidopsis thaliana to study the role of zinc in regulating growth. We identify allelic variation of the systemic immunity gene AZI1 as a key for determining root growth responses to low zinc conditions. We further demonstrate that this gene is important for modulating primary root length depending on the zinc and defence status. Finally, we show that the interaction of the immunity signal azelaic acid and zinc level to regulate root growth is conserved in rice. This work demonstrates that there is a common genetic and molecular basis for multiple zinc dependent processes and that nutrient cues can determine the balance of growth and immune responses in plants.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29608565</pmid><doi>10.1371/journal.pgen.1007304</doi><orcidid>https://orcid.org/0000-0002-2770-656X</orcidid><orcidid>https://orcid.org/0000-0003-0831-1463</orcidid><orcidid>https://orcid.org/0000-0003-2042-7290</orcidid><orcidid>https://orcid.org/0000-0002-7751-0477</orcidid><orcidid>https://orcid.org/0000-0003-3358-2417</orcidid><orcidid>https://orcid.org/0000-0003-3965-9972</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1553-7404 |
| ispartof | PLoS genetics, 2018-04, Vol.14 (4), p.e1007304-e1007304 |
| issn | 1553-7404 1553-7390 1553-7404 |
| language | eng |
| recordid | cdi_plos_journals_2056434042 |
| source | Public Library of Science (PLoS) Journals Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Alleles Arabidopsis thaliana Biology and Life Sciences Cellular biology Gene expression Genetic aspects Genetic variation Genetics Genomes Health aspects Immune response Laboratories Life Sciences Mendel, Gregor (1822-84) Physical Sciences Physiology Plant resistance Plant sciences Proteins Research and Analysis Methods Rice Studies Vegetal Biology Zinc Zinc (Nutrient) |
| title | Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T08%3A56%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Natural%20allelic%20variation%20of%20the%20AZI1%20gene%20controls%20root%20growth%20under%20zinc-limiting%20condition&rft.jtitle=PLoS%20genetics&rft.au=Bouain,%20Nadia&rft.date=2018-04-02&rft.volume=14&rft.issue=4&rft.spage=e1007304&rft.epage=e1007304&rft.pages=e1007304-e1007304&rft.issn=1553-7404&rft.eissn=1553-7404&rft_id=info:doi/10.1371/journal.pgen.1007304&rft_dat=%3Cgale_plos_%3EA536809363%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2056434042&rft_id=info:pmid/29608565&rft_galeid=A536809363&rft_doaj_id=oai_doaj_org_article_ec2e7ce725fa4af1894755b960f51c96&rfr_iscdi=true |