Frequency and distribution of 152 genetic disease variants in over 100,000 mixed breed and purebred dogs

Knowledge on the genetic epidemiology of disorders in the dog population has implications for both veterinary medicine and sustainable breeding. Limited data on frequencies of genetic disease variants across breeds exists, and the disease heritage of mixed breed dogs remains poorly explored to date....

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Veröffentlicht in:	PLoS genetics 2018-04, Vol.14 (4), p.e1007361-e1007361
Hauptverfasser:	Donner, Jonas, Anderson, Heidi, Davison, Stephen, Hughes, Angela M, Bouirmane, Julia, Lindqvist, Johan, Lytle, Katherine M, Ganesan, Balasubramanian, Ottka, Claudia, Ruotanen, Päivi, Kaukonen, Maria, Forman, Oliver P, Fretwell, Neale, Cole, Cynthia A, Lohi, Hannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal welfare Animals Biology and Life Sciences Breeding Breeding of animals Databases, Genetic Deoxyribonucleic acid DNA DNA microarrays Dog diseases Dog Diseases - epidemiology Dog Diseases - genetics Dogs Dogs - genetics Engineering and Technology Epidemiology Female Gene Frequency Genes, Recessive Genetic aspects Genetic disorders Genetic diversity Genetic Predisposition to Disease Genetic screening Genetic Testing - veterinary Genetic Variation Genome-wide association studies Genomes Hybrid Vigor Laboratories Male Medicine and Health Sciences Molecular Epidemiology Mutation Oligonucleotide Array Sequence Analysis - veterinary Population genetics Prevalence Rare diseases Species Specificity Supervision Veterinary medicine Vigor
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