Neuropathic-like symptoms and the association with joint-specific function and quality of life in patients with hip and knee osteoarthritis
There is an association between osteoarthritis-related pain severity and function, yet clear evidence about the sole influence of neuropathic-like symptoms on joint function and health-related quality of life (HRQoL) is lacking. Previous studies among knee OA patients show an association between neu...
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| Veröffentlicht in: | PloS one 2018-06, Vol.13 (6), p.e0199165-e0199165 |
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| creator | Blikman, Tim Rienstra, Wietske van Raay, Jos J A M Dijkstra, Baukje Bulstra, Sjoerd K Stevens, Martin van den Akker-Scheek, Inge |
| description | There is an association between osteoarthritis-related pain severity and function, yet clear evidence about the sole influence of neuropathic-like symptoms on joint function and health-related quality of life (HRQoL) is lacking. Previous studies among knee OA patients show an association between neuropathic-like symptoms, lower functional status and lower quality of life, however analyses were unadjusted or had limited adjustment for influential covariates like pain intensity. The aim of this study was therefore to determine the influence of neuropathic-like symptoms-adjusted for multiple influential covariates-on joint-specific function and HRQoL in hip and knee OA patients.
In this observational study 255 patients (117 with hip OA and 138 with knee OA) completed the modified painDETECT questionnaire (mPDQ) to identify subjects with neuropathic-like symptoms (mPDQ score>12, possible neuropathic pain [NP] phenotype). The WOMAC and the RAND-36 were used to asses respectively function and HRQoL. Results were adjusted stepwise for age, sex and BMI (Model 1); back disorder, painful body regions, comorbidities and previous surgery (Model 2); and pain intensity and analgesic usage (Model 3).
A possible NP phenotype was experienced by 37% of hip and 46% of knee OA patients. Final model 3 analysis revealed that hip OA patients with neuropathic-like symptoms scored significantly lower on pain-related aspects of HRQoL (ΔRAND-36 bodily pain: 6.8 points, p = 0.047) compared to patients with the unlikely NP phenotype. In knee OA patients, a possible NP phenotype was associated with diminished joint function (ΔWOMAC domains ranging 7.1 to 10.5 points, p |
| doi_str_mv | 10.1371/journal.pone.0199165 |
| format | Article |
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In this observational study 255 patients (117 with hip OA and 138 with knee OA) completed the modified painDETECT questionnaire (mPDQ) to identify subjects with neuropathic-like symptoms (mPDQ score>12, possible neuropathic pain [NP] phenotype). The WOMAC and the RAND-36 were used to asses respectively function and HRQoL. Results were adjusted stepwise for age, sex and BMI (Model 1); back disorder, painful body regions, comorbidities and previous surgery (Model 2); and pain intensity and analgesic usage (Model 3).
A possible NP phenotype was experienced by 37% of hip and 46% of knee OA patients. Final model 3 analysis revealed that hip OA patients with neuropathic-like symptoms scored significantly lower on pain-related aspects of HRQoL (ΔRAND-36 bodily pain: 6.8 points, p = 0.047) compared to patients with the unlikely NP phenotype. In knee OA patients, a possible NP phenotype was associated with diminished joint function (ΔWOMAC domains ranging 7.1 to 10.5 points, p<0.05) and more deficits on the physical functional aspect of HRQoL (ΔRAND-36 physical functioning: 6.8 points, p = 0.016).
Neuropathic-like symptoms deteriorate the subjective rating of pain-related quality of life in hip OA patients and significantly influence function in knee OA patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0199165</identifier><identifier>PMID: 29902245</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Analgesics ; Analysis ; Biocompatibility ; Biology and Life Sciences ; Body mass ; Care and treatment ; Female ; Health aspects ; Hip ; Hip Joint - physiopathology ; Hospitals ; Humans ; Influence functions ; Joint surgery ; Knee ; Knee Joint - physiopathology ; Knee pain ; Male ; Medicine and Health Sciences ; Middle Aged ; Nervous system ; Neuralgia ; Neuralgia - complications ; Neuropathy ; Observational studies ; Organ Specificity ; Orthopedics ; Osteoarthritis ; Osteoarthritis, Hip - complications ; Osteoarthritis, Hip - physiopathology ; Osteoarthritis, Knee - complications ; Osteoarthritis, Knee - physiopathology ; Pain ; Patients ; Phenotypes ; Physical Sciences ; Quality of Life ; Questionnaires ; Rheumatoid arthritis ; Studies ; Surgery ; Taxonomy</subject><ispartof>PloS one, 2018-06, Vol.13 (6), p.e0199165-e0199165</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Blikman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Blikman et al 2018 Blikman et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-6fda939547c61c3387aef17f7c89a34d1365e1cc8e397b28acd80af140c11b213</citedby><cites>FETCH-LOGICAL-c692t-6fda939547c61c3387aef17f7c89a34d1365e1cc8e397b28acd80af140c11b213</cites><orcidid>0000-0002-6318-6450</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002060/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002060/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29902245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blikman, Tim</creatorcontrib><creatorcontrib>Rienstra, Wietske</creatorcontrib><creatorcontrib>van Raay, Jos J A M</creatorcontrib><creatorcontrib>Dijkstra, Baukje</creatorcontrib><creatorcontrib>Bulstra, Sjoerd K</creatorcontrib><creatorcontrib>Stevens, Martin</creatorcontrib><creatorcontrib>van den Akker-Scheek, Inge</creatorcontrib><title>Neuropathic-like symptoms and the association with joint-specific function and quality of life in patients with hip and knee osteoarthritis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>There is an association between osteoarthritis-related pain severity and function, yet clear evidence about the sole influence of neuropathic-like symptoms on joint function and health-related quality of life (HRQoL) is lacking. Previous studies among knee OA patients show an association between neuropathic-like symptoms, lower functional status and lower quality of life, however analyses were unadjusted or had limited adjustment for influential covariates like pain intensity. The aim of this study was therefore to determine the influence of neuropathic-like symptoms-adjusted for multiple influential covariates-on joint-specific function and HRQoL in hip and knee OA patients.
In this observational study 255 patients (117 with hip OA and 138 with knee OA) completed the modified painDETECT questionnaire (mPDQ) to identify subjects with neuropathic-like symptoms (mPDQ score>12, possible neuropathic pain [NP] phenotype). The WOMAC and the RAND-36 were used to asses respectively function and HRQoL. Results were adjusted stepwise for age, sex and BMI (Model 1); back disorder, painful body regions, comorbidities and previous surgery (Model 2); and pain intensity and analgesic usage (Model 3).
A possible NP phenotype was experienced by 37% of hip and 46% of knee OA patients. Final model 3 analysis revealed that hip OA patients with neuropathic-like symptoms scored significantly lower on pain-related aspects of HRQoL (ΔRAND-36 bodily pain: 6.8 points, p = 0.047) compared to patients with the unlikely NP phenotype. In knee OA patients, a possible NP phenotype was associated with diminished joint function (ΔWOMAC domains ranging 7.1 to 10.5 points, p<0.05) and more deficits on the physical functional aspect of HRQoL (ΔRAND-36 physical functioning: 6.8 points, p = 0.016).
Neuropathic-like symptoms deteriorate the subjective rating of pain-related quality of life in hip OA patients and significantly influence function in knee OA patients.</description><subject>Aged</subject><subject>Analgesics</subject><subject>Analysis</subject><subject>Biocompatibility</subject><subject>Biology and Life Sciences</subject><subject>Body mass</subject><subject>Care and treatment</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hip</subject><subject>Hip Joint - physiopathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Influence functions</subject><subject>Joint surgery</subject><subject>Knee</subject><subject>Knee Joint - physiopathology</subject><subject>Knee pain</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neuralgia</subject><subject>Neuralgia - complications</subject><subject>Neuropathy</subject><subject>Observational studies</subject><subject>Organ Specificity</subject><subject>Orthopedics</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Hip - complications</subject><subject>Osteoarthritis, Hip - physiopathology</subject><subject>Osteoarthritis, Knee - complications</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Pain</subject><subject>Patients</subject><subject>Phenotypes</subject><subject>Physical Sciences</subject><subject>Quality of Life</subject><subject>Questionnaires</subject><subject>Rheumatoid arthritis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Taxonomy</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk8tu1DAUhiMEoqXwBggsISFYZPAlceJNpariMlJFJW5by-PYE089dho7wDwDL40zk1YN6gJ5Yev4-_9jH_tk2XMEF4hU6N3GD70TdtF5pxYQMYZo-SA7RozgnGJIHt5ZH2VPQthAWJKa0sfZEWYMYlyUx9mfz2rofSdia2RuzZUCYbftot8GIFwDYquACMFLI6LxDvwysQUbb1zMQ6ek0UYCPTi53xwF14OwJu6A18AarYBxIJkb5WI4iFvT7cErpxTwISov-tj2JprwNHukhQ3q2TSfZN8_vP92_im_uPy4PD-7yCVlOOZUN4IRVhaVpEgSUldCaVTpStZMkKJBhJYKSVkrwqoVroVsaig0KqBEaIUROcleHnw76wOf6hg4hmVJEYKIJGJ5IBovNrzrzVb0O-6F4fuA79c8ndpIq3hT4qaoaghlWadZCUnEilaolrBGKzh6nU7ZhtVWNTKVohd2Zjrfcabla_-TUwgxpDAZvJkMen89qBD51gSprBVO-WF_bkoYxnTM9eof9P7bTdRapAsYp33KK0dTflYWBLOCFmPaxT1UGo3aGpk-nTYpPhO8nQkSE9XvuBZDCHz59cv_s5c_5uzrO2yrhI1t8HYY_1yYg8UBlL0PoVf6tsgI8rFnbqrBx57hU88k2Yu7D3QrumkS8heFShNN</recordid><startdate>20180614</startdate><enddate>20180614</enddate><creator>Blikman, Tim</creator><creator>Rienstra, Wietske</creator><creator>van Raay, Jos J A M</creator><creator>Dijkstra, Baukje</creator><creator>Bulstra, Sjoerd K</creator><creator>Stevens, Martin</creator><creator>van den Akker-Scheek, Inge</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6318-6450</orcidid></search><sort><creationdate>20180614</creationdate><title>Neuropathic-like symptoms and the association with joint-specific function and quality of life in patients with hip and knee osteoarthritis</title><author>Blikman, Tim ; Rienstra, Wietske ; van Raay, Jos J A M ; Dijkstra, Baukje ; Bulstra, Sjoerd K ; Stevens, Martin ; van den Akker-Scheek, Inge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-6fda939547c61c3387aef17f7c89a34d1365e1cc8e397b28acd80af140c11b213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Analgesics</topic><topic>Analysis</topic><topic>Biocompatibility</topic><topic>Biology and Life Sciences</topic><topic>Body mass</topic><topic>Care and treatment</topic><topic>Female</topic><topic>Health aspects</topic><topic>Hip</topic><topic>Hip Joint - physiopathology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Influence functions</topic><topic>Joint surgery</topic><topic>Knee</topic><topic>Knee Joint - physiopathology</topic><topic>Knee pain</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neuralgia</topic><topic>Neuralgia - complications</topic><topic>Neuropathy</topic><topic>Observational studies</topic><topic>Organ Specificity</topic><topic>Orthopedics</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Hip - complications</topic><topic>Osteoarthritis, Hip - physiopathology</topic><topic>Osteoarthritis, Knee - complications</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Pain</topic><topic>Patients</topic><topic>Phenotypes</topic><topic>Physical Sciences</topic><topic>Quality of Life</topic><topic>Questionnaires</topic><topic>Rheumatoid arthritis</topic><topic>Studies</topic><topic>Surgery</topic><topic>Taxonomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blikman, Tim</creatorcontrib><creatorcontrib>Rienstra, Wietske</creatorcontrib><creatorcontrib>van Raay, Jos J A M</creatorcontrib><creatorcontrib>Dijkstra, Baukje</creatorcontrib><creatorcontrib>Bulstra, Sjoerd K</creatorcontrib><creatorcontrib>Stevens, Martin</creatorcontrib><creatorcontrib>van den Akker-Scheek, Inge</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - 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Previous studies among knee OA patients show an association between neuropathic-like symptoms, lower functional status and lower quality of life, however analyses were unadjusted or had limited adjustment for influential covariates like pain intensity. The aim of this study was therefore to determine the influence of neuropathic-like symptoms-adjusted for multiple influential covariates-on joint-specific function and HRQoL in hip and knee OA patients.
In this observational study 255 patients (117 with hip OA and 138 with knee OA) completed the modified painDETECT questionnaire (mPDQ) to identify subjects with neuropathic-like symptoms (mPDQ score>12, possible neuropathic pain [NP] phenotype). The WOMAC and the RAND-36 were used to asses respectively function and HRQoL. Results were adjusted stepwise for age, sex and BMI (Model 1); back disorder, painful body regions, comorbidities and previous surgery (Model 2); and pain intensity and analgesic usage (Model 3).
A possible NP phenotype was experienced by 37% of hip and 46% of knee OA patients. Final model 3 analysis revealed that hip OA patients with neuropathic-like symptoms scored significantly lower on pain-related aspects of HRQoL (ΔRAND-36 bodily pain: 6.8 points, p = 0.047) compared to patients with the unlikely NP phenotype. In knee OA patients, a possible NP phenotype was associated with diminished joint function (ΔWOMAC domains ranging 7.1 to 10.5 points, p<0.05) and more deficits on the physical functional aspect of HRQoL (ΔRAND-36 physical functioning: 6.8 points, p = 0.016).
Neuropathic-like symptoms deteriorate the subjective rating of pain-related quality of life in hip OA patients and significantly influence function in knee OA patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29902245</pmid><doi>10.1371/journal.pone.0199165</doi><tpages>e0199165</tpages><orcidid>https://orcid.org/0000-0002-6318-6450</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; Full-Text Journals in Chemistry (Open access); PubMed Central; Directory of Open Access Journals; EZB Electronic Journals Library |
| subjects | Aged Analgesics Analysis Biocompatibility Biology and Life Sciences Body mass Care and treatment Female Health aspects Hip Hip Joint - physiopathology Hospitals Humans Influence functions Joint surgery Knee Knee Joint - physiopathology Knee pain Male Medicine and Health Sciences Middle Aged Nervous system Neuralgia Neuralgia - complications Neuropathy Observational studies Organ Specificity Orthopedics Osteoarthritis Osteoarthritis, Hip - complications Osteoarthritis, Hip - physiopathology Osteoarthritis, Knee - complications Osteoarthritis, Knee - physiopathology Pain Patients Phenotypes Physical Sciences Quality of Life Questionnaires Rheumatoid arthritis Studies Surgery Taxonomy |
| title | Neuropathic-like symptoms and the association with joint-specific function and quality of life in patients with hip and knee osteoarthritis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T18%3A45%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neuropathic-like%20symptoms%20and%20the%20association%20with%20joint-specific%20function%20and%20quality%20of%20life%20in%20patients%20with%20hip%20and%20knee%20osteoarthritis&rft.jtitle=PloS%20one&rft.au=Blikman,%20Tim&rft.date=2018-06-14&rft.volume=13&rft.issue=6&rft.spage=e0199165&rft.epage=e0199165&rft.pages=e0199165-e0199165&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0199165&rft_dat=%3Cgale_plos_%3EA543294640%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2055611013&rft_id=info:pmid/29902245&rft_galeid=A543294640&rft_doaj_id=oai_doaj_org_article_d52d47800c58478eac3ab6718c081b03&rfr_iscdi=true |