Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease

Angiotensin converting enzyme 2 (ACE2) is an endogenous regulator of the renin angiotensin system. Increased circulating ACE2 predicts adverse outcomes in patients with heart failure (HF), but it is unknown if elevated plasma ACE2 activity predicts major adverse cardiovascular events (MACE) in patie...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0198144-e0198144
Hauptverfasser:	Ramchand, Jay, Patel, Sheila K, Srivastava, Piyush M, Farouque, Omar, Burrell, Louise M
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Acute coronary syndromes Aged Angiography Angiotensin Angiotensin converting enzyme Angiotensin-converting enzyme 2 Atherosclerosis Biology and Life Sciences Biomarkers - blood Bone surgery Cardiology Cardiovascular disease Cardiovascular diseases Care and treatment Confidence intervals Coronary Angiography Coronary artery Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - complications Coronary Artery Disease - diagnosis Coronary Artery Disease - mortality Coronary heart disease Coronary Occlusion - blood Coronary Occlusion - complications Coronary Occlusion - diagnosis Coronary Occlusion - mortality Coronary vessels Development and progression Diabetes Enzyme regulation Enzymes Female Follow-Up Studies Genetic aspects Health aspects Heart Heart attacks Heart diseases Heart failure Heart Failure - blood Heart Failure - diagnosis Heart Failure - etiology Heart Failure - mortality Humans Hypertension Kidney diseases Male Medical imaging Medicine Medicine and Health Sciences Middle Aged Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - diagnosis Myocardial Infarction - etiology Myocardial Infarction - mortality Patients Peptidyl-Dipeptidase A - blood Plasma Prognosis Rank tests Renin Stenosis Systematic review Tomography, X-Ray Computed Transplants & implants Up-Regulation
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