Membrane-associated human tyrosinase is an enzymatically active monomeric glycoprotein

Human tyrosinase (hTyr) is a Type 1 membrane bound glycoenzyme that catalyzes the initial and rate-limiting steps of melanin production in the melanosome. Mutations in the Tyr gene are linked to oculocutaneous albinism type 1 (OCA1), an autosomal recessive disorder. Currently, the application of enz...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0198247-e0198247
Hauptverfasser:	Kus, Nicole J, Dolinska, Monika B, Young, 2nd, Kenneth L, Dimitriadis, Emilios K, Wingfield, Paul T, Sergeev, Yuri V
Format:	Artikel
Sprache:	eng
Schlagworte:	Albinism Albinism, Oculocutaneous - enzymology Albinism, Oculocutaneous - genetics Albinism, Oculocutaneous - therapy Analysis Baculovirus Biochemistry Biology and Life Sciences Care and treatment Chromatography Dihydroxyphenylalanine Disease Dopa Enzymatic activity Enzyme Replacement Therapy Enzymes Genetic aspects Glycoprotein Glycoproteins Hereditary diseases Humans Kinetics Larvae Levodopa Medicine and Health Sciences Melanin Molecular chains Molecular weight Monophenol Monooxygenase - chemistry Monophenol Monooxygenase - genetics Monophenol Monooxygenase - therapeutic use Mutation Oculocutaneous albinism Physical Sciences Polypeptides Protein Domains Proteins Reaction kinetics Recombinant Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - therapeutic use Research and Analysis Methods Residues Sedimentation & deposition Trichoplusia ni TYR gene Tyrosinase Tyrosine Ultracentrifugation
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