Cigarette toxin 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces experimental pancreatitis through α7 nicotinic acetylcholine receptors (nAChRs) in mice

Clinical studies have shown that cigarette smoking is a dose-dependent and independent risk factor for acute pancreatitis. Cigarette smoke contains nicotine which can be converted to the potent receptor ligand and toxin, NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone]. Previously, we have shown...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0197362
Hauptverfasser:	Alahmari, A A, Sreekumar, B, Patel, V, Ashat, M, Alexandre, M, Uduman, A K, Akinbiyi, E O, Ceplenski, A, Shugrue, C A, Kolodecik, T R, Tashkandi, N, Messenger, S W, Groblewski, G E, Gorelick, F S, Thrower, E C
Format:	Artikel
Sprache:	eng
Schlagworte:	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Acetylcholine receptors (nicotinic) Acinar cells Activation Alcohol alpha7 Nicotinic Acetylcholine Receptor - genetics Animals Biology and Life Sciences Calcium Carcinogens - toxicity Cell Proliferation - drug effects Cigarette smoke Cigarette smoking Cigarettes Clonal deletion Disease Edema Gene Deletion Humans Infiltration Internal medicine Markers Medicine Medicine and Health Sciences Mice Mice, Knockout Nervous system Nicotiana - toxicity Nicotine Nicotine - metabolism Nitrosamines - toxicity Pancreas Pancreatitis Pancreatitis - chemically induced Pancreatitis - genetics Pancreatitis - pathology Pharmacology Proenzymes Protein kinase C Receptors Research and Analysis Methods Risk factors Rodents Smoke Smoking Trypsinogen Veterans
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