Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein

RNA viruses induce specialized membranous structures for use in genome replication. These structures are often referred to as replication organelles (ROs). ROs exhibit distinct lipid composition relative to other cellular membranes. In many picornaviruses, phosphatidylinositol-4-phosphate (PI4P) is...

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Veröffentlicht in:	PLoS pathogens 2018-05, Vol.14 (5), p.e1007086-e1007086
Hauptverfasser:	Banerjee, Sravani, Aponte-Diaz, David, Yeager, Calvin, Sharma, Suresh D, Ning, Gang, Oh, Hyung S, Han, Qingxia, Umeda, Masato, Hara, Yuji, Wang, Robert Y L, Cameron, Craig E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate ADP-ribosylation factor ADP-Ribosylation Factor 1 - metabolism Analysis Biochemistry Biology and Life Sciences Brefeldin A Brefeldin A - pharmacology Cell Membrane - ultrastructure Dactinomycin - pharmacology Derivatives Engineering schools Foot & mouth disease Genetic aspects Genomes Golgi apparatus Golgi Apparatus - drug effects Golgi Apparatus - metabolism Guanine Guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - metabolism HeLa Cells Hepatitis Humans Infections Kinases Lecithin Lipid composition Membrane lipids Membranes Microscopy, Electron, Transmission Molecular biology Organelle Biogenesis Organelles Peptide Hydrolases - metabolism Phosphatidylcholine Phosphatidylinositol 4,5-diphosphate Phosphatidylinositol Phosphates - metabolism Phospholipids Phospholipids - biosynthesis Picornaviridae - enzymology Picornaviruses Poliovirus - enzymology Protein Synthesis Inhibitors - pharmacology Proteins Pyridines - pharmacology Quinolines - pharmacology Replication Research and analysis methods Resistance factors Ribonucleic acid RNA RNA polymerase RNA viruses Synthesis Viral infections Viral proteins Viral Proteins - metabolism Virology Viruses West Nile virus
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