Peroxidasin contributes to lung host defense by direct binding and killing of gram-negative bacteria

Innate immune recognition is classically mediated by the interaction of host pattern-recognition receptors and pathogen-associated molecular patterns; this triggers a series of downstream signaling events that facilitate killing and elimination of invading pathogens. In this report, we provide the f...

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Veröffentlicht in:	PLoS pathogens 2018-05, Vol.14 (5), p.e1007026
Hauptverfasser:	Shi, Ruizheng, Cao, Zehong, Li, Hong, Graw, Jochen, Zhang, Guogang, Thannickal, Victor J, Cheng, Guangjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animal models Animals Anti-Bacterial Agents - immunology Anti-Bacterial Agents - metabolism Bacteria Bactericidal activity Biology and Life Sciences Care and treatment Cataracts Critical care Cystic fibrosis Development and progression Escherichia coli - drug effects Escherichia coli - immunology Extracellular Matrix Proteins - metabolism Extracellular Matrix Proteins - pharmacology Female Gene expression Genetic aspects Genetics Glaucoma Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - immunology Gram-negative bacterial infections Health aspects Host-bacteria relationships Immune response Immunity, Innate - immunology Leucine Lipopolysaccharides Lung - immunology Lung - microbiology Lungs Male Mammals Medicine Medicine and Health Sciences Mice Mice, Inbred C57BL Microorganisms Molecular chains Mutation Pathogens Pattern recognition Peroxidase Peroxidase - metabolism Peroxidase - pharmacology Peroxidasin Physiology Proteins Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - immunology Pseudomonas Infections - immunology Receptors Research and Analysis Methods Respiratory Tract Infections - immunology Signal Transduction
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