Lipids and pathogenic flaviviruses: An intimate union
Flaviviridae: A growing family of human pathogens Among the major contributors to the positive-strand RNA virus global disease burden are the flaviviruses, a genus of enveloped viruses that includes Yellow fever virus (YFV), Zika virus (ZIKV), Dengue virus (DENV), and West Nile virus (WNV) and is cl...
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| description | Flaviviridae: A growing family of human pathogens Among the major contributors to the positive-strand RNA virus global disease burden are the flaviviruses, a genus of enveloped viruses that includes Yellow fever virus (YFV), Zika virus (ZIKV), Dengue virus (DENV), and West Nile virus (WNV) and is closely related to Hepatitis C virus (HCV) [2]. Cer, ceramide; Chol, cholesterol; DAG, diacylglycerol; ER, endoplasmic reticulum; FFA, free fatty acids; GalCer, galactosylceramide; GlcCer, glucosylceramide; GSPL, complex glycosphingolipids; mTOR, mammalian target of rapamycin; NS, nonstructural; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PIP2, phosphatidylinositol-(4,5)-bisphosphate; PI, phosphatidylinositol; PIP3, phosphatidylinositol-(3,4,5)-trisphosphate; PM, plasma membrane; PS, phosphatidylserine; S1P, sphingosine-1-phosphate; SM, sphingomyelin; TAG, triacylglycerol; Ve, invaginated vesicles. https://doi.org/10.1371/journal.ppat.1006952.g001 Replication complex assembly remakes the host lipid landscape Inducing the negative membrane curvature required for vesicle formation is a thermodynamically unfavorable process [16]. [...]LD lipids may be required for multiple aspects of flavivirus infection and pathogenesis, from providing the raw materials and energy for replication to supporting efficient encapsidation and assembly of viral particles. Fatty acid synthesis is regulated by sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors also responsible for controlling cholesterol biosynthesis [30]. |
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Cer, ceramide; Chol, cholesterol; DAG, diacylglycerol; ER, endoplasmic reticulum; FFA, free fatty acids; GalCer, galactosylceramide; GlcCer, glucosylceramide; GSPL, complex glycosphingolipids; mTOR, mammalian target of rapamycin; NS, nonstructural; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PIP2, phosphatidylinositol-(4,5)-bisphosphate; PI, phosphatidylinositol; PIP3, phosphatidylinositol-(3,4,5)-trisphosphate; PM, plasma membrane; PS, phosphatidylserine; S1P, sphingosine-1-phosphate; SM, sphingomyelin; TAG, triacylglycerol; Ve, invaginated vesicles. https://doi.org/10.1371/journal.ppat.1006952.g001 Replication complex assembly remakes the host lipid landscape Inducing the negative membrane curvature required for vesicle formation is a thermodynamically unfavorable process [16]. [...]LD lipids may be required for multiple aspects of flavivirus infection and pathogenesis, from providing the raw materials and energy for replication to supporting efficient encapsidation and assembly of viral particles. Fatty acid synthesis is regulated by sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors also responsible for controlling cholesterol biosynthesis [30].</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1006952</identifier><identifier>PMID: 29746606</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Biosynthesis ; Cholesterol ; Cytoplasm ; Dengue ; Dengue fever ; Dengue virus ; Disease ; Endoplasmic reticulum ; Fatty acids ; Flavivirus ; Flaviviruses ; Genomes ; Genomics ; Hepatitis ; Immunology ; Infections ; Lipid metabolism ; Lipids ; Medicine and Health Sciences ; Membranes ; Microcephaly ; Neurosciences ; Pearls ; Phosphatidylcholine ; Proteins ; Raw materials ; Stem cells ; Vector-borne diseases ; Virology ; Virus replication ; West Nile virus ; Zika virus</subject><ispartof>PLoS pathogens, 2018-05, Vol.14 (5), p.e1006952-e1006952</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Leier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Cer, ceramide; Chol, cholesterol; DAG, diacylglycerol; ER, endoplasmic reticulum; FFA, free fatty acids; GalCer, galactosylceramide; GlcCer, glucosylceramide; GSPL, complex glycosphingolipids; mTOR, mammalian target of rapamycin; NS, nonstructural; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PIP2, phosphatidylinositol-(4,5)-bisphosphate; PI, phosphatidylinositol; PIP3, phosphatidylinositol-(3,4,5)-trisphosphate; PM, plasma membrane; PS, phosphatidylserine; S1P, sphingosine-1-phosphate; SM, sphingomyelin; TAG, triacylglycerol; Ve, invaginated vesicles. https://doi.org/10.1371/journal.ppat.1006952.g001 Replication complex assembly remakes the host lipid landscape Inducing the negative membrane curvature required for vesicle formation is a thermodynamically unfavorable process [16]. [...]LD lipids may be required for multiple aspects of flavivirus infection and pathogenesis, from providing the raw materials and energy for replication to supporting efficient encapsidation and assembly of viral particles. 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Cer, ceramide; Chol, cholesterol; DAG, diacylglycerol; ER, endoplasmic reticulum; FFA, free fatty acids; GalCer, galactosylceramide; GlcCer, glucosylceramide; GSPL, complex glycosphingolipids; mTOR, mammalian target of rapamycin; NS, nonstructural; PC, phosphatidylcholine; PE, phosphatidylethanolamine; PIP2, phosphatidylinositol-(4,5)-bisphosphate; PI, phosphatidylinositol; PIP3, phosphatidylinositol-(3,4,5)-trisphosphate; PM, plasma membrane; PS, phosphatidylserine; S1P, sphingosine-1-phosphate; SM, sphingomyelin; TAG, triacylglycerol; Ve, invaginated vesicles. https://doi.org/10.1371/journal.ppat.1006952.g001 Replication complex assembly remakes the host lipid landscape Inducing the negative membrane curvature required for vesicle formation is a thermodynamically unfavorable process [16]. [...]LD lipids may be required for multiple aspects of flavivirus infection and pathogenesis, from providing the raw materials and energy for replication to supporting efficient encapsidation and assembly of viral particles. Fatty acid synthesis is regulated by sterol regulatory element-binding proteins (SREBPs), a family of membrane-bound transcription factors also responsible for controlling cholesterol biosynthesis [30].</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29746606</pmid><doi>10.1371/journal.ppat.1006952</doi><orcidid>https://orcid.org/0000-0002-8575-4164</orcidid><orcidid>https://orcid.org/0000-0002-0363-1444</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biology and Life Sciences Biosynthesis Cholesterol Cytoplasm Dengue Dengue fever Dengue virus Disease Endoplasmic reticulum Fatty acids Flavivirus Flaviviruses Genomes Genomics Hepatitis Immunology Infections Lipid metabolism Lipids Medicine and Health Sciences Membranes Microcephaly Neurosciences Pearls Phosphatidylcholine Proteins Raw materials Stem cells Vector-borne diseases Virology Virus replication West Nile virus Zika virus |
| title | Lipids and pathogenic flaviviruses: An intimate union |
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