Mesenchymal stromal cells from human umbilical cord prevent the development of lung fibrosis in immunocompetent mice

Lung fibrosis is a severe condition resulting from several interstial lung diseases (ILD) with different etiologies. Current therapy of ILD, especially those associated with connective tissue diseases, is rather limited and new anti-fibrotic strategies are needed. In this study, we investigated the...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0196048-e0196048
Hauptverfasser:	Moroncini, Gianluca, Paolini, Chiara, Orlando, Fiorenza, Capelli, Chiara, Grieco, Antonella, Tonnini, Cecilia, Agarbati, Silvia, Mondini, Eleonora, Saccomanno, Stefania, Goteri, Gaia, Svegliati Baroni, Silvia, Provinciali, Mauro, Introna, Martino, Del Papa, Nicoletta, Gabrielli, Armando
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biology and Life Sciences Bleomycin Bone marrow Cesarean section Clinical trials Collagen Connective tissue diseases Connective tissues Cytokines - metabolism Disease Models, Animal Etiology Female Fetal Blood - metabolism Fibrosis Health aspects Heterografts Humans Immunocompetence In vivo methods and tests Inflammation Injury prevention Interleukin 1 Interleukin 10 Interleukin 6 Lung - metabolism Lung - pathology Lung diseases Lungs Macrophages Macrophages - metabolism Macrophages - pathology Medical research Medicine and Health Sciences Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mesenchyme Mice Prevention Pulmonary fibrosis Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Pulmonary Fibrosis - therapy Rats Research and Analysis Methods Stem cells Stromal cells Therapy Transplants & implants Umbilical cord
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