Fatty liver index is a predictor of incident diabetes in patients with prediabetes: The PREDAPS study

We evaluated the ability of the Fatty Liver Index (FLI), a surrogate marker of hepatic steatosis, to predict the development of type 2 diabetes (T2D) at 3 years follow-up in a Spanish cohort with prediabetes from a prospective observational study in primary care (PREDAPS). FLI was calculated at base...

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Veröffentlicht in:	PloS one 2018-06, Vol.13 (6), p.e0198327-e0198327
Hauptverfasser:	Franch-Nadal, Josep, Caballeria, Llorenç, Mata-Cases, Manel, Mauricio, Didac, Giraldez-García, Carolina, Mancera, José, Goday, Albert, Mundet-Tudurí, Xavier, Regidor, Enrique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alcohol use Atenció primària Biology and Life Sciences Biomarkers Biomedical research Cardiovascular disease Cohort Studies Confidence intervals Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology Diabetis Disease prevention Disease Progression Disorders of metabolism Education Endocrinology Enzymes Epidemiology Evaluation Fatty acids Fatty liver Female Genetics Health care Health status indicators Hospitals Humans Hypertension Incidence Insulin resistance Liver Liver diseases Male Medicine and Health Sciences Metabolic disorders Metabolic syndrome Middle Aged Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - epidemiology Patients Physiological aspects Prediabetic State - complications Prediabetic State - diagnosis Prediabetic State - epidemiology Prediabetic State - pathology Preventive medicine Primary health care Prognosis Pronòstic mèdic Public health Regression analysis Regression models Risk Factors Science history Severity of Illness Index Sex Statistical analysis Steatosis Studies Transaminases Trastorns del metabolisme Triglycerides Type 2 diabetes Ultrasonic imaging
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Beschreibung
Zusammenfassung:	We evaluated the ability of the Fatty Liver Index (FLI), a surrogate marker of hepatic steatosis, to predict the development of type 2 diabetes (T2D) at 3 years follow-up in a Spanish cohort with prediabetes from a prospective observational study in primary care (PREDAPS). FLI was calculated at baseline for 1,142 adult subjects with prediabetes attending primary care centers, and classified into three categories: FLI
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0198327