MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors
Multi-modality image-guided radiotherapy is the standard of care in contemporary cancer management; however, it is not common in preclinical settings due to both hardware and software limitations. Soft tissue lesions, such as orthotopic prostate tumors, are difficult to identify using cone beam comp...
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| creator | Chiu, Tsuicheng D Arai, Tatsuya J Campbell Iii, James Jiang, Steve B Mason, Ralph P Stojadinovic, Strahinja |
| description | Multi-modality image-guided radiotherapy is the standard of care in contemporary cancer management; however, it is not common in preclinical settings due to both hardware and software limitations. Soft tissue lesions, such as orthotopic prostate tumors, are difficult to identify using cone beam computed tomography (CBCT) imaging alone. In this study, we characterized a research magnetic resonance (MR) scanner for preclinical studies and created a protocol for combined MR-CBCT image-guided small animal radiotherapy. Two in-house dual-modality, MR and CBCT compatible, phantoms were designed and manufactured using 3D printing technology. The phantoms were used for quality assurance tests and to facilitate end-to-end testing for combined preclinical MR and CBCT based treatment planning. MR and CBCT images of the phantoms were acquired utilizing a Varian 4.7 T scanner and XRad-225Cx irradiator, respectively. The geometry distortion was assessed by comparing MR images to phantom blueprints and CBCT. The corrected MR scans were co-registered with CBCT and subsequently used for treatment planning. The fidelity of 3D printed phantoms compared to the blueprint design yielded favorable agreement as verified with the CBCT measurements. The geometric distortion, which varied between -5% and 11% throughout the scanning volume, was substantially reduced to within 0.4% after correction. The distortion free MR images were co-registered with the corresponding CBCT images and imported into a commercial treatment planning software SmART Plan. The planning target volume (PTV) was on average 19% smaller when contoured on the corrected MR-CBCT images relative to raw images without distortion correction. An MR-CBCT based preclinical workflow was successfully designed and implemented for small animal radiotherapy. Combined MR-CBCT image-guided radiotherapy for preclinical research potentially delivers enhanced relevance to human radiotherapy for various disease sites. This novel protocol is wide-ranging and not limited to the orthotopic prostate tumor study presented in the study. |
| doi_str_mv | 10.1371/journal.pone.0198065 |
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Soft tissue lesions, such as orthotopic prostate tumors, are difficult to identify using cone beam computed tomography (CBCT) imaging alone. In this study, we characterized a research magnetic resonance (MR) scanner for preclinical studies and created a protocol for combined MR-CBCT image-guided small animal radiotherapy. Two in-house dual-modality, MR and CBCT compatible, phantoms were designed and manufactured using 3D printing technology. The phantoms were used for quality assurance tests and to facilitate end-to-end testing for combined preclinical MR and CBCT based treatment planning. MR and CBCT images of the phantoms were acquired utilizing a Varian 4.7 T scanner and XRad-225Cx irradiator, respectively. The geometry distortion was assessed by comparing MR images to phantom blueprints and CBCT. The corrected MR scans were co-registered with CBCT and subsequently used for treatment planning. The fidelity of 3D printed phantoms compared to the blueprint design yielded favorable agreement as verified with the CBCT measurements. The geometric distortion, which varied between -5% and 11% throughout the scanning volume, was substantially reduced to within 0.4% after correction. The distortion free MR images were co-registered with the corresponding CBCT images and imported into a commercial treatment planning software SmART Plan. The planning target volume (PTV) was on average 19% smaller when contoured on the corrected MR-CBCT images relative to raw images without distortion correction. An MR-CBCT based preclinical workflow was successfully designed and implemented for small animal radiotherapy. Combined MR-CBCT image-guided radiotherapy for preclinical research potentially delivers enhanced relevance to human radiotherapy for various disease sites. This novel protocol is wide-ranging and not limited to the orthotopic prostate tumor study presented in the study.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0198065</identifier><identifier>PMID: 29847586</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biology ; Biology and Life Sciences ; Calibration ; Cancer ; Cancer therapies ; Care and treatment ; CAT scans ; Computed tomography ; Computer programs ; Cone-Beam Computed Tomography ; Coordinate transformations ; Design ; Disease control ; Distortion ; Drug dosages ; Geometry ; Hypoxia ; Image acquisition ; Image enhancement ; Image Processing, Computer-Assisted ; Lesions ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Medical research ; Medicine and Health Sciences ; NMR ; Nuclear magnetic resonance ; Oncology ; Phantoms, Imaging ; Physical Sciences ; Physics ; Prostate ; Prostate cancer ; Prostatic Neoplasms - diagnostic imaging ; Prostatic Neoplasms - radiotherapy ; Quality assurance ; Radiation therapy ; Radiotherapy ; Radiotherapy Planning, Computer-Assisted ; Radiotherapy, Image-Guided - methods ; Rats ; Research and Analysis Methods ; Scanners ; Three dimensional printing ; Tumors ; Workflow</subject><ispartof>PloS one, 2018-05, Vol.13 (5), p.e0198065-e0198065</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication: https://creativecommons.org/publicdomain/zero/1.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-4396769a9a1099e9dd13b80b406ed821223f02fd8219e61c341c9438c1f8abaf3</citedby><cites>FETCH-LOGICAL-c692t-4396769a9a1099e9dd13b80b406ed821223f02fd8219e61c341c9438c1f8abaf3</cites><orcidid>0000-0001-9280-3641</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976174/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976174/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29847586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wang, Ying-Jan</contributor><creatorcontrib>Chiu, Tsuicheng D</creatorcontrib><creatorcontrib>Arai, Tatsuya J</creatorcontrib><creatorcontrib>Campbell Iii, James</creatorcontrib><creatorcontrib>Jiang, Steve B</creatorcontrib><creatorcontrib>Mason, Ralph P</creatorcontrib><creatorcontrib>Stojadinovic, Strahinja</creatorcontrib><title>MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Multi-modality image-guided radiotherapy is the standard of care in contemporary cancer management; however, it is not common in preclinical settings due to both hardware and software limitations. 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The fidelity of 3D printed phantoms compared to the blueprint design yielded favorable agreement as verified with the CBCT measurements. The geometric distortion, which varied between -5% and 11% throughout the scanning volume, was substantially reduced to within 0.4% after correction. The distortion free MR images were co-registered with the corresponding CBCT images and imported into a commercial treatment planning software SmART Plan. The planning target volume (PTV) was on average 19% smaller when contoured on the corrected MR-CBCT images relative to raw images without distortion correction. An MR-CBCT based preclinical workflow was successfully designed and implemented for small animal radiotherapy. Combined MR-CBCT image-guided radiotherapy for preclinical research potentially delivers enhanced relevance to human radiotherapy for various disease sites. 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imaging</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Oncology</subject><subject>Phantoms, Imaging</subject><subject>Physical Sciences</subject><subject>Physics</subject><subject>Prostate</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Quality assurance</subject><subject>Radiation therapy</subject><subject>Radiotherapy</subject><subject>Radiotherapy Planning, Computer-Assisted</subject><subject>Radiotherapy, Image-Guided - methods</subject><subject>Rats</subject><subject>Research and Analysis Methods</subject><subject>Scanners</subject><subject>Three dimensional 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image-guided system for radiotherapy of orthotopic rat prostate tumors</title><author>Chiu, Tsuicheng D ; Arai, Tatsuya J ; Campbell Iii, James ; Jiang, Steve B ; Mason, Ralph P ; Stojadinovic, Strahinja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-4396769a9a1099e9dd13b80b406ed821223f02fd8219e61c341c9438c1f8abaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Calibration</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>CAT scans</topic><topic>Computed tomography</topic><topic>Computer programs</topic><topic>Cone-Beam Computed Tomography</topic><topic>Coordinate transformations</topic><topic>Design</topic><topic>Disease control</topic><topic>Distortion</topic><topic>Drug 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due to both hardware and software limitations. Soft tissue lesions, such as orthotopic prostate tumors, are difficult to identify using cone beam computed tomography (CBCT) imaging alone. In this study, we characterized a research magnetic resonance (MR) scanner for preclinical studies and created a protocol for combined MR-CBCT image-guided small animal radiotherapy. Two in-house dual-modality, MR and CBCT compatible, phantoms were designed and manufactured using 3D printing technology. The phantoms were used for quality assurance tests and to facilitate end-to-end testing for combined preclinical MR and CBCT based treatment planning. MR and CBCT images of the phantoms were acquired utilizing a Varian 4.7 T scanner and XRad-225Cx irradiator, respectively. The geometry distortion was assessed by comparing MR images to phantom blueprints and CBCT. The corrected MR scans were co-registered with CBCT and subsequently used for treatment planning. The fidelity of 3D printed phantoms compared to the blueprint design yielded favorable agreement as verified with the CBCT measurements. The geometric distortion, which varied between -5% and 11% throughout the scanning volume, was substantially reduced to within 0.4% after correction. The distortion free MR images were co-registered with the corresponding CBCT images and imported into a commercial treatment planning software SmART Plan. The planning target volume (PTV) was on average 19% smaller when contoured on the corrected MR-CBCT images relative to raw images without distortion correction. An MR-CBCT based preclinical workflow was successfully designed and implemented for small animal radiotherapy. Combined MR-CBCT image-guided radiotherapy for preclinical research potentially delivers enhanced relevance to human radiotherapy for various disease sites. This novel protocol is wide-ranging and not limited to the orthotopic prostate tumor study presented in the study.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29847586</pmid><doi>10.1371/journal.pone.0198065</doi><tpages>e0198065</tpages><orcidid>https://orcid.org/0000-0001-9280-3641</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Biology Biology and Life Sciences Calibration Cancer Cancer therapies Care and treatment CAT scans Computed tomography Computer programs Cone-Beam Computed Tomography Coordinate transformations Design Disease control Distortion Drug dosages Geometry Hypoxia Image acquisition Image enhancement Image Processing, Computer-Assisted Lesions Magnetic resonance Magnetic Resonance Imaging Male Medical imaging Medical research Medicine and Health Sciences NMR Nuclear magnetic resonance Oncology Phantoms, Imaging Physical Sciences Physics Prostate Prostate cancer Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - radiotherapy Quality assurance Radiation therapy Radiotherapy Radiotherapy Planning, Computer-Assisted Radiotherapy, Image-Guided - methods Rats Research and Analysis Methods Scanners Three dimensional printing Tumors Workflow |
| title | MR-CBCT image-guided system for radiotherapy of orthotopic rat prostate tumors |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T13%3A18%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MR-CBCT%20image-guided%20system%20for%20radiotherapy%20of%20orthotopic%20rat%20prostate%20tumors&rft.jtitle=PloS%20one&rft.au=Chiu,%20Tsuicheng%20D&rft.date=2018-05-30&rft.volume=13&rft.issue=5&rft.spage=e0198065&rft.epage=e0198065&rft.pages=e0198065-e0198065&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0198065&rft_dat=%3Cgale_plos_%3EA540865636%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2047226767&rft_id=info:pmid/29847586&rft_galeid=A540865636&rft_doaj_id=oai_doaj_org_article_1b136ad632814b52bc4f9f3839c4fe35&rfr_iscdi=true |