Prognostic significance of NF-κB expression in non-small cell lung cancer: A meta-analysis
Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evalua...
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| description | Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity. The results of analysis were presented as hazard ratio (HR) or odds ratios (OR) with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients and NF-kB cellular localization within cancer cells were conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2>50% and P |
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However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity. The results of analysis were presented as hazard ratio (HR) or odds ratios (OR) with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients and NF-kB cellular localization within cancer cells were conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2>50% and P<0.05, and random-effects model was used. The combined results indicated that higher NF-κB expression was associated with shorter overall survival (OS) of NSCLC patients (HR = 2.78, 95% CI = 1.51-5.12, P = 0.001). Moreover, NF-κB expression was closely associated with tumor stage (HR = 0.32, 95% CI = 0.18-0.57, P<0.0001), lymph node metastasis (HR = 0.56, 95% CI = 0.38-0.83, P = 0.004) and 5-year OS for NSCLC patients (OR = 1.83, 95% CI = 1.02-3.31, P = 0.04). We conclude that NF-κB expression may be a potential unfavorable prognostic marker for NSCLC patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0198223</identifier><identifier>PMID: 29813121</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Apoptosis ; Biology and Life Sciences ; Breast cancer ; Cancer ; Confidence intervals ; Heterogeneity ; Histology ; Localization ; Lung cancer ; Lung diseases ; Lymph nodes ; Lymphatic system ; Medical prognosis ; Medicine and Health Sciences ; Meta-analysis ; Metastases ; Metastasis ; Minority & ethnic groups ; NF-κB protein ; Non-small cell lung carcinoma ; Patients ; Physical Sciences ; Prognosis ; Research and Analysis Methods ; Respiratory diseases ; Statistical analysis ; Subgroups ; Survival ; Tumor necrosis factor-TNF</subject><ispartof>PloS one, 2018-05, Vol.13 (5), p.e0198223-e0198223</ispartof><rights>2018 Gu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Gu et al 2018 Gu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-39bfb01c4b85be223548ffae07219c4397b7b12c1b0e48cab5c782657dc77f733</citedby><cites>FETCH-LOGICAL-c526t-39bfb01c4b85be223548ffae07219c4397b7b12c1b0e48cab5c782657dc77f733</cites><orcidid>0000-0002-0527-7944</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973575/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973575/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23868,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29813121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Marcu, Kenneth B.</contributor><creatorcontrib>Gu, Lijun</creatorcontrib><creatorcontrib>Wang, Zhiyan</creatorcontrib><creatorcontrib>Zuo, Jing</creatorcontrib><creatorcontrib>Li, Hongmei</creatorcontrib><creatorcontrib>Zha, Lin</creatorcontrib><title>Prognostic significance of NF-κB expression in non-small cell lung cancer: A meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity. The results of analysis were presented as hazard ratio (HR) or odds ratios (OR) with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients and NF-kB cellular localization within cancer cells were conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2>50% and P<0.05, and random-effects model was used. The combined results indicated that higher NF-κB expression was associated with shorter overall survival (OS) of NSCLC patients (HR = 2.78, 95% CI = 1.51-5.12, P = 0.001). Moreover, NF-κB expression was closely associated with tumor stage (HR = 0.32, 95% CI = 0.18-0.57, P<0.0001), lymph node metastasis (HR = 0.56, 95% CI = 0.38-0.83, P = 0.004) and 5-year OS for NSCLC patients (OR = 1.83, 95% CI = 1.02-3.31, P = 0.04). We conclude that NF-κB expression may be a potential unfavorable prognostic marker for NSCLC patients.</description><subject>Apoptosis</subject><subject>Biology and Life Sciences</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Confidence intervals</subject><subject>Heterogeneity</subject><subject>Histology</subject><subject>Localization</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Meta-analysis</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Minority & ethnic groups</subject><subject>NF-κB protein</subject><subject>Non-small cell lung carcinoma</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Prognosis</subject><subject>Research and Analysis Methods</subject><subject>Respiratory diseases</subject><subject>Statistical 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gu, Lijun</au><au>Wang, Zhiyan</au><au>Zuo, Jing</au><au>Li, Hongmei</au><au>Zha, Lin</au><au>Marcu, Kenneth B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of NF-κB expression in non-small cell lung cancer: A meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-05-29</date><risdate>2018</risdate><volume>13</volume><issue>5</issue><spage>e0198223</spage><epage>e0198223</epage><pages>e0198223-e0198223</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Nuclear factor kappa B (NF-κB), a key nuclear transcription factor, is associated with prognosis in a variety of human cancers. However, the clinical value of NF-κB in non-small cell lung cancer (NSCLC) is still controversial. Therefore, the aim of this meta-analysis was to obtain an accurate evaluation of the relationship between NF-κB expression and survival prognosis of NSCLC patients based on published articles. PubMed, EMBASE and Web of Science databases were systematically searched for potential articles. A total of 1159 patients from 7 eligible studies comparing prognostic significance of NF-κB expression levels in NSCLC were included in our meta-analysis. I2 statistic and P value were performed to evaluate heterogeneity. The results of analysis were presented as hazard ratio (HR) or odds ratios (OR) with 95% confidence interval (95% CI). Subgroup analysis based on ethnicity of NSCLC patients and NF-kB cellular localization within cancer cells were conducted to illustrate the potential discrepancy. Significant heterogeneity was considered at I2>50% and P<0.05, and random-effects model was used. The combined results indicated that higher NF-κB expression was associated with shorter overall survival (OS) of NSCLC patients (HR = 2.78, 95% CI = 1.51-5.12, P = 0.001). Moreover, NF-κB expression was closely associated with tumor stage (HR = 0.32, 95% CI = 0.18-0.57, P<0.0001), lymph node metastasis (HR = 0.56, 95% CI = 0.38-0.83, P = 0.004) and 5-year OS for NSCLC patients (OR = 1.83, 95% CI = 1.02-3.31, P = 0.04). We conclude that NF-κB expression may be a potential unfavorable prognostic marker for NSCLC patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29813121</pmid><doi>10.1371/journal.pone.0198223</doi><orcidid>https://orcid.org/0000-0002-0527-7944</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Biology and Life Sciences Breast cancer Cancer Confidence intervals Heterogeneity Histology Localization Lung cancer Lung diseases Lymph nodes Lymphatic system Medical prognosis Medicine and Health Sciences Meta-analysis Metastases Metastasis Minority & ethnic groups NF-κB protein Non-small cell lung carcinoma Patients Physical Sciences Prognosis Research and Analysis Methods Respiratory diseases Statistical analysis Subgroups Survival Tumor necrosis factor-TNF |
| title | Prognostic significance of NF-κB expression in non-small cell lung cancer: A meta-analysis |
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