Prefronto-cortical dopamine D1 receptor sensitivity can critically influence working memory maintenance during delayed response tasks

The dopamine (DA) hypothesis of cognitive deficits suggests that too low or too high extracellular DA concentration in the prefrontal cortex (PFC) can severely impair the working memory (WM) maintenance during delay period. Thus, there exists only an optimal range of DA where the sustained-firing ac...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0198136-e0198136
Hauptverfasser:	Reneaux, Melissa, Gupta, Rahul
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Binding sites Biology and Life Sciences Brain Cognitive ability Complications and side effects Delayed response Dopamine Dopamine D1 receptors Firing pattern Firing rate Hypotheses Maintenance Medicine and Health Sciences Memory Mental disorders Neural networks Neurons Neurosciences Physical Sciences Physiology Population Prefrontal cortex Receptor mechanisms Robustness Schizophrenia Sensitivity Short term memory Social Sciences
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