Gut-Microbiota-Metabolite Axis in Early Renal Function Decline

Several circulating metabolites derived from bacterial protein fermentation have been found to be inversely associated with renal function but the timing and disease severity is unclear. The aim of this study is to explore the relationship between indoxyl-sulfate, p-cresyl-sulfate, phenylacetylgluta...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0134311-e0134311
Hauptverfasser:	Barrios, Clara, Beaumont, Michelle, Pallister, Tess, Villar, Judith, Goodrich, Julia K, Clark, Andrew, Pascual, Julio, Ley, Ruth E, Spector, Tim D, Bell, Jordana T, Menni, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anaerobic microorganisms Body Mass Index Cardiovascular disease Clostridiales Clostridiales - classification Clostridiales - isolation & purification Clostridiales - metabolism Cresols - blood Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - microbiology Diabetic Nephropathies - blood Diabetic Nephropathies - genetics Diabetic Nephropathies - microbiology Digestive system Digestive tract Diseases in Twins - blood Diseases in Twins - genetics Diseases in Twins - microbiology Epidemiology Epidermal growth factor receptors Feces - microbiology Female Fermentation Flora Gastrointestinal Microbiome - physiology Gastrointestinal tract Genetics Glomerular Filtration Rate Glutamine - analogs & derivatives Glutamine - blood Health aspects Hospitals Humans Indican - blood Infectious diseases Intestinal microflora Intestine Kidney diseases Kidney Diseases - blood Kidney Diseases - genetics Kidney Diseases - microbiology Male Metabolism Metabolites Metabolome Microbiomes Microbiota Microbiota (Symbiotic organisms) Microorganisms Middle Aged Molecular biology Nephrology Physiological aspects Population Proteins Renal function Ribotyping Studies Sulfates Sulfuric Acid Esters - blood Taxonomy
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