LMP1 Increases Expression of NADPH Oxidase (NOX) and Its Regulatory Subunit p22 in NP69 Nasopharyngeal Cells and Makes Them Sensitive to a Treatment by a NOX Inhibitor

Oxidative stress is thought to contribute to cancer development. Epstein-Barr virus (EBV) and its encoded oncoprotein, latent membrane protein 1 (LMP1), are closely associated with the transformation of nasopharyngeal carcinoma (NPC) and Burkitt's lymphoma (BL). In this study, we used LMP1-tran...

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Veröffentlicht in:	PloS one 2015-08, Vol.10 (8), p.e0134896-e0134896
Hauptverfasser:	Sun, Jian, Hu, Chongyu, Zhu, Yinghui, Sun, Rui, Fang, Yujing, Fan, Yuhua, Xu, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Apoptosis Burkitt's lymphoma c-Jun protein Cancer Carcinoma Cell Line Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cellular signal transduction Coding Collaboration Cytotoxicity Enzyme Inhibitors - pharmacology Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - virology Epstein-Barr virus Flow cytometry Gene Expression Regulation, Neoplastic Glycolysis Herpesvirus 4, Human - genetics Herpesvirus 4, Human - metabolism Herpesvirus 4, Human - physiology Host-Pathogen Interactions - genetics Humans Immunoblotting Immunohistochemistry Inhibitors JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases Laboratories Latent membrane protein 1 Lymphoma Medicine Membrane proteins Metabolism NAD NAD(P)H oxidase NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism Nasopharyngeal Carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - virology Nasopharynx - metabolism Nasopharynx - pathology Nasopharynx - virology Oncology Onium Compounds - pharmacology Oxidase Oxidative stress Oxygen Oxygen consumption Phosphatidylinositol 3-Kinases - metabolism Physiological aspects Proteins Proto-Oncogene Proteins c-akt - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Throat cancer Transcription factors Transformation Tumor necrosis factor-TNF Tumors Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Viruses
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