Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction
Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We perfo...
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| description | Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls. Lysophosphatidylcholine (lysoPC) and lysophosphatidylethanolamine (lysoPE) species containing unsaturated fatty acids and free fatty acids were associated with an increased risk of CAD, whereas species of lysoPC and lyso-alkyl PC containing saturated fatty acids were associated with a decreased risk. Additionally, PC species containing palmitic acid, diacylglycerol, sphingomyelin, and ceramide were associated with an increased risk of MI, whereas PE-plasmalogen and phosphatidylinositol species were associated with a decreased risk. In MI patients, we found strong positive correlation between lipid metabolites related to the sphingolipid pathway, sphingomyelin, and ceramide and acute inflammatory markers (high-sensitivity C-reactive protein). The results of this study demonstrate altered signatures in lipid metabolism in patients with angina or MI. Lipidomic profiling could provide the information to identity the specific lipid metabolites under the presence of disturbed metabolic pathways in patients with CAD. |
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However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls. Lysophosphatidylcholine (lysoPC) and lysophosphatidylethanolamine (lysoPE) species containing unsaturated fatty acids and free fatty acids were associated with an increased risk of CAD, whereas species of lysoPC and lyso-alkyl PC containing saturated fatty acids were associated with a decreased risk. Additionally, PC species containing palmitic acid, diacylglycerol, sphingomyelin, and ceramide were associated with an increased risk of MI, whereas PE-plasmalogen and phosphatidylinositol species were associated with a decreased risk. In MI patients, we found strong positive correlation between lipid metabolites related to the sphingolipid pathway, sphingomyelin, and ceramide and acute inflammatory markers (high-sensitivity C-reactive protein). The results of this study demonstrate altered signatures in lipid metabolism in patients with angina or MI. Lipidomic profiling could provide the information to identity the specific lipid metabolites under the presence of disturbed metabolic pathways in patients with CAD.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0135228</identifier><identifier>PMID: 26258408</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Analysis ; Angina ; Angina pectoris ; Angina Pectoris - blood ; Angina Pectoris - diagnosis ; Angina Pectoris - pathology ; Arteriosclerosis ; Atherosclerosis ; Biomarkers - blood ; Body mass ; Body mass index ; Body size ; C-reactive protein ; C-Reactive Protein - metabolism ; Cardiac patients ; Case-Control Studies ; Ceramide ; Chromatography ; Coronary artery ; Coronary artery disease ; Diacylglycerol ; Diglycerides ; Fatty acids ; Fatty Acids - blood ; Fatty Acids, Nonesterified - blood ; Fatty Acids, Unsaturated - blood ; Female ; Heart attack ; Heart diseases ; Humans ; Indexing ; Infarction ; Inflammation ; Lipid Metabolism ; Lipids ; Liquid chromatography ; Low density lipoprotein ; Lysophosphatidylcholine ; Lysophosphatidylcholines - blood ; Lysophospholipids - blood ; Male ; Mass spectrometry ; Mass spectroscopy ; Metabolic pathways ; Metabolism ; Metabolites ; Metabolome ; Middle Aged ; Multivariate Analysis ; Multivariate statistical analysis ; Myocardial infarction ; Myocardial Infarction - blood ; Myocardial Infarction - diagnosis ; Myocardial Infarction - pathology ; Oxidation ; Palmitic acid ; Patients ; Phosphatidylinositol ; Profiling ; Proteins ; Regulators ; Risk ; Rodents ; Saturated fatty acids ; Species ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Sphingomyelin ; Statistical analysis ; Statistical methods ; Studies ; Unsaturated fatty acids</subject><ispartof>PloS one, 2015-08, Vol.10 (8), p.e0135228-e0135228</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Park et al 2015 Park et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-74bf649b926fc8994dbd7b4712f7bbf125868d13c70b2661fb7cb93ae081b4c13</citedby><cites>FETCH-LOGICAL-c692t-74bf649b926fc8994dbd7b4712f7bbf125868d13c70b2661fb7cb93ae081b4c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530944/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530944/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26258408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Ju Yeon</creatorcontrib><creatorcontrib>Lee, Sang-Hak</creatorcontrib><creatorcontrib>Shin, Min-Jeong</creatorcontrib><creatorcontrib>Hwang, Geum-Sook</creatorcontrib><title>Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls. Lysophosphatidylcholine (lysoPC) and lysophosphatidylethanolamine (lysoPE) species containing unsaturated fatty acids and free fatty acids were associated with an increased risk of CAD, whereas species of lysoPC and lyso-alkyl PC containing saturated fatty acids were associated with a decreased risk. Additionally, PC species containing palmitic acid, diacylglycerol, sphingomyelin, and ceramide were associated with an increased risk of MI, whereas PE-plasmalogen and phosphatidylinositol species were associated with a decreased risk. In MI patients, we found strong positive correlation between lipid metabolites related to the sphingolipid pathway, sphingomyelin, and ceramide and acute inflammatory markers (high-sensitivity C-reactive protein). The results of this study demonstrate altered signatures in lipid metabolism in patients with angina or MI. Lipidomic profiling could provide the information to identity the specific lipid metabolites under the presence of disturbed metabolic pathways in patients with CAD.</description><subject>Aged</subject><subject>Analysis</subject><subject>Angina</subject><subject>Angina pectoris</subject><subject>Angina Pectoris - blood</subject><subject>Angina Pectoris - diagnosis</subject><subject>Angina Pectoris - pathology</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Biomarkers - blood</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiac patients</subject><subject>Case-Control Studies</subject><subject>Ceramide</subject><subject>Chromatography</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Diacylglycerol</subject><subject>Diglycerides</subject><subject>Fatty acids</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Female</subject><subject>Heart attack</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Indexing</subject><subject>Infarction</subject><subject>Inflammation</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Liquid chromatography</subject><subject>Low density lipoprotein</subject><subject>Lysophosphatidylcholine</subject><subject>Lysophosphatidylcholines - blood</subject><subject>Lysophospholipids - blood</subject><subject>Male</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Metabolic pathways</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolome</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Multivariate statistical analysis</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - pathology</subject><subject>Oxidation</subject><subject>Palmitic acid</subject><subject>Patients</subject><subject>Phosphatidylinositol</subject><subject>Profiling</subject><subject>Proteins</subject><subject>Regulators</subject><subject>Risk</subject><subject>Rodents</subject><subject>Saturated fatty acids</subject><subject>Species</subject><subject>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</subject><subject>Sphingomyelin</subject><subject>Statistical analysis</subject><subject>Statistical methods</subject><subject>Studies</subject><subject>Unsaturated fatty acids</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7jr6D0QLgujFjPlq09wsDIsfAwsLft2GJE07GdJmNknV_femO91hKnshvUhJnvc9nDc5WfYSghXEFH7YucH3wq72rtcrAHGBUPUoO4cMo2WJAH588n-WPQthB0CBq7J8mp2hEhUVAdV5drO2UXsRjetz0-edjkI6a1QeTNuLOHidi77Ordmb-ngaupHdJ5XuY8h_m7hNVGt6ke-1is6bcKfqbp0SvjbCJr4RXo1lnmdPGmGDfjGti-zHp4_fL78sr64_by7XV0tVMhSXlMimJEwyVDaqYozUsqaSUIgaKmUDUwNlVUOsKJCoLGEjqZIMCw0qKImCeJG9PvjurQt8SitwBAhmhIICJWJzIGondnzvTSf8LXfC8LsN51sufDTKak5hARSkkAKqiKiEYBiCBismcYOobJLXxVRtkJ2uVQrGCzsznZ_0Zstb94uTAgNGSDJ4Nxl4dzPoEHlngtLWil67IfBUOt16SdIdLrI3_6APdzdRrUgNpPxdqqtGU74mqACwQmxMafUAlb5ad0alp9WYtD8TvJ8JEhP1n9iKIQS--fb1_9nrn3P27Qm71cLGbXB2GJ9MmIPkACrvQvC6OYYMAR8n4z4NPk4GnyYjyV6dXtBRdD8K-C-9Awmp</recordid><startdate>20150810</startdate><enddate>20150810</enddate><creator>Park, Ju Yeon</creator><creator>Lee, Sang-Hak</creator><creator>Shin, Min-Jeong</creator><creator>Hwang, Geum-Sook</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150810</creationdate><title>Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction</title><author>Park, Ju Yeon ; Lee, Sang-Hak ; Shin, Min-Jeong ; Hwang, Geum-Sook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-74bf649b926fc8994dbd7b4712f7bbf125868d13c70b2661fb7cb93ae081b4c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Analysis</topic><topic>Angina</topic><topic>Angina pectoris</topic><topic>Angina Pectoris - blood</topic><topic>Angina Pectoris - diagnosis</topic><topic>Angina Pectoris - pathology</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Biomarkers - blood</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiac patients</topic><topic>Case-Control Studies</topic><topic>Ceramide</topic><topic>Chromatography</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Diacylglycerol</topic><topic>Diglycerides</topic><topic>Fatty acids</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Female</topic><topic>Heart attack</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Indexing</topic><topic>Infarction</topic><topic>Inflammation</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Liquid chromatography</topic><topic>Low density lipoprotein</topic><topic>Lysophosphatidylcholine</topic><topic>Lysophosphatidylcholines - blood</topic><topic>Lysophospholipids - blood</topic><topic>Male</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Metabolic pathways</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolome</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Multivariate statistical analysis</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - pathology</topic><topic>Oxidation</topic><topic>Palmitic acid</topic><topic>Patients</topic><topic>Phosphatidylinositol</topic><topic>Profiling</topic><topic>Proteins</topic><topic>Regulators</topic><topic>Risk</topic><topic>Rodents</topic><topic>Saturated fatty acids</topic><topic>Species</topic><topic>Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization</topic><topic>Sphingomyelin</topic><topic>Statistical analysis</topic><topic>Statistical methods</topic><topic>Studies</topic><topic>Unsaturated fatty acids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Ju Yeon</creatorcontrib><creatorcontrib>Lee, Sang-Hak</creatorcontrib><creatorcontrib>Shin, Min-Jeong</creatorcontrib><creatorcontrib>Hwang, Geum-Sook</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Ju Yeon</au><au>Lee, Sang-Hak</au><au>Shin, Min-Jeong</au><au>Hwang, Geum-Sook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-08-10</date><risdate>2015</risdate><volume>10</volume><issue>8</issue><spage>e0135228</spage><epage>e0135228</epage><pages>e0135228-e0135228</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Lipid metabolites are indispensable regulators of physiological and pathological processes, including atherosclerosis and coronary artery disease (CAD). However, the complex changes in lipid metabolites and metabolism that occur in patients with these conditions are incompletely understood. We performed lipid profiling to identify alterations in lipid metabolism in patients with angina and myocardial infarction (MI). Global lipid profiling was applied to serum samples from patients with CAD (angina and MI) and age-, sex-, and body mass index-matched healthy subjects using ultra-performance liquid chromatography/quadruple time-of-flight mass spectrometry and multivariate statistical analysis. A multivariate analysis showed a clear separation between the patients with CAD and normal controls. Lysophosphatidylcholine (lysoPC) and lysophosphatidylethanolamine (lysoPE) species containing unsaturated fatty acids and free fatty acids were associated with an increased risk of CAD, whereas species of lysoPC and lyso-alkyl PC containing saturated fatty acids were associated with a decreased risk. Additionally, PC species containing palmitic acid, diacylglycerol, sphingomyelin, and ceramide were associated with an increased risk of MI, whereas PE-plasmalogen and phosphatidylinositol species were associated with a decreased risk. In MI patients, we found strong positive correlation between lipid metabolites related to the sphingolipid pathway, sphingomyelin, and ceramide and acute inflammatory markers (high-sensitivity C-reactive protein). The results of this study demonstrate altered signatures in lipid metabolism in patients with angina or MI. Lipidomic profiling could provide the information to identity the specific lipid metabolites under the presence of disturbed metabolic pathways in patients with CAD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26258408</pmid><doi>10.1371/journal.pone.0135228</doi><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Analysis Angina Angina pectoris Angina Pectoris - blood Angina Pectoris - diagnosis Angina Pectoris - pathology Arteriosclerosis Atherosclerosis Biomarkers - blood Body mass Body mass index Body size C-reactive protein C-Reactive Protein - metabolism Cardiac patients Case-Control Studies Ceramide Chromatography Coronary artery Coronary artery disease Diacylglycerol Diglycerides Fatty acids Fatty Acids - blood Fatty Acids, Nonesterified - blood Fatty Acids, Unsaturated - blood Female Heart attack Heart diseases Humans Indexing Infarction Inflammation Lipid Metabolism Lipids Liquid chromatography Low density lipoprotein Lysophosphatidylcholine Lysophosphatidylcholines - blood Lysophospholipids - blood Male Mass spectrometry Mass spectroscopy Metabolic pathways Metabolism Metabolites Metabolome Middle Aged Multivariate Analysis Multivariate statistical analysis Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - diagnosis Myocardial Infarction - pathology Oxidation Palmitic acid Patients Phosphatidylinositol Profiling Proteins Regulators Risk Rodents Saturated fatty acids Species Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Sphingomyelin Statistical analysis Statistical methods Studies Unsaturated fatty acids |
| title | Alteration in metabolic signature and lipid metabolism in patients with angina pectoris and myocardial infarction |
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