Manganese-porphyrin-enhanced MRI for the detection of cancer cells: A quantitative in vitro investigation with multiple clinical subtypes of breast cancer

Magnetic resonance imaging (MRI) contrast agents (CAs) are chemical compounds that can enhance image contrast on T1- or T2- weighted MR image. We have previously demonstrated the potential of MnCl2, a manganese-based CA, in cellular imaging of breast cancer using T1-weighted MRI. In this work, we ex...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0196998
Hauptverfasser:	Alhamami, Mosa, Cheng, Weiran, Lyu, Yuanyuan, Allen, Christine, Zhang, Xiao-An, Cheng, Hai-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology and Life Sciences Biomedical engineering Biomedical materials Brain cancer Breast cancer Breast Neoplasms - diagnostic imaging Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Line, Tumor Cell Survival - drug effects Chemical compounds Contrast agents Contrast media Contrast Media - chemistry Contrast Media - pharmacokinetics Contrast Media - pharmacology Cytotoxicity Diagnosis Engineering Environmental science Female Gadolinium Gadolinium DTPA - chemistry Gadolinium DTPA - pharmacokinetics Gadolinium DTPA - pharmacology Humans Image contrast Image enhancement Investigations Magnetic resonance Magnetic resonance imaging Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Mammography Manganese Manganese (Metal) MCF-7 Cells Medical imaging Medical research Medicine Medicine and Health Sciences NMR Nuclear magnetic resonance Pharmaceutical sciences Pharmacy Physical Sciences Porphyrins Porphyrins - chemistry Porphyrins - pharmacokinetics Porphyrins - pharmacology Research and Analysis Methods Statistical analysis Stem cells Toxicity Tumors
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