A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications

Kava is regaining its popularity with detailed characterizations warranted. We developed an ultraperformance liquid chromatography high-resolution tandem mass spectrometry (UPLC-MS/MS) method for major kavalactones (kavain, dihydrokavain, methysticin, dihydromethysticin and desmethoxyyangonin) with...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0197940-e0197940
Hauptverfasser:	Wang, Yi, Eans, Shainnel O, Stacy, Heather M, Narayanapillai, Sreekanth C, Sharma, Abhisheak, Fujioka, Naomi, Haddad, Linda, McLaughlin, Jay, Avery, Bonnie A, Xing, Chengguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology and Life Sciences Body fluids Cancer Chemistry Chromatography Dilution Drug dosages Humans Kava - chemistry Laboratory animals Lactones - administration & dosage Lactones - analysis Lactones - pharmacokinetics Liquid chromatography Male Mass spectrometry Mass spectroscopy Medicine and Health Sciences Methods Mice Mice, Inbred C57BL NMR Nuclear magnetic resonance Pharmaceutical sciences Pharmacokinetics Pharmacology Physical Sciences Piper methysticum Plasmas Pyrones - administration & dosage Pyrones - analysis Pyrones - pharmacokinetics Radioisotope Dilution Technique Research and Analysis Methods Scientific imaging Spectroscopy Stable isotopes Studies Tandem Mass Spectrometry - methods Tissue Distribution Urinalysis
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