Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs
Formation of episodic memories (i.e. remembered experiences) requires a process called consolidation which involves communication between the neocortex and hippocampus. However, the neuromodulatory mechanisms underlying this neocortico-hippocampal communication are poorly understood. Here, we examin...
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| description | Formation of episodic memories (i.e. remembered experiences) requires a process called consolidation which involves communication between the neocortex and hippocampus. However, the neuromodulatory mechanisms underlying this neocortico-hippocampal communication are poorly understood. Here, we examined the involvement of dopamine D1 receptors (D1R) and D2 receptors (D2R) mediated signaling on memory consolidation using the Novel Object Recognition (NOR) test. We conducted the tests in male Hartley guinea pigs and cognitive behaviors were assessed in customized Phenotyper home cages utilizing Ethovision XT software from Noldus enabled for the 3-point detection system (nose, center of the body, and rear). We found that acute intraperitoneal injections of either 0.25 mg/kg SCH23390 to block D1Rs or 1.0 mg/kg sulpiride to block D2Rs soon after acquisition (which involved familiarization to two similar objects) attenuated subsequent discrimination for novel objects when tested after 5-hours in the NOR test. By contrast guinea pigs treated with saline showed robust discrimination for novel objects indicating normal operational processes undergirding memory consolidation. The data suggests that involvement of dopaminergic signaling is a key post-acquisition factor in modulating memory consolidation in guinea pigs. |
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However, the neuromodulatory mechanisms underlying this neocortico-hippocampal communication are poorly understood. Here, we examined the involvement of dopamine D1 receptors (D1R) and D2 receptors (D2R) mediated signaling on memory consolidation using the Novel Object Recognition (NOR) test. We conducted the tests in male Hartley guinea pigs and cognitive behaviors were assessed in customized Phenotyper home cages utilizing Ethovision XT software from Noldus enabled for the 3-point detection system (nose, center of the body, and rear). We found that acute intraperitoneal injections of either 0.25 mg/kg SCH23390 to block D1Rs or 1.0 mg/kg sulpiride to block D2Rs soon after acquisition (which involved familiarization to two similar objects) attenuated subsequent discrimination for novel objects when tested after 5-hours in the NOR test. By contrast guinea pigs treated with saline showed robust discrimination for novel objects indicating normal operational processes undergirding memory consolidation. The data suggests that involvement of dopaminergic signaling is a key post-acquisition factor in modulating memory consolidation in guinea pigs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0135578</identifier><identifier>PMID: 26275140</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Benzazepines - pharmacology ; Blocking ; Cages ; Cognitive ability ; Consolidation ; Dopamine ; Dopamine D1 receptors ; Dopamine D2 Receptor Antagonists - pharmacology ; Dopamine D2 receptors ; Guinea Pigs ; Hippocampus ; Laboratories ; Learning ; Male ; Mammals ; Memory ; Memory Consolidation - drug effects ; Memory Consolidation - physiology ; Molecular weight ; Motor Activity - drug effects ; Neocortex ; Neuromodulation ; Neurons ; Neurosciences ; Nose ; Object recognition ; Pattern recognition ; Pharmacology ; Phenotypes ; Receptors ; Receptors, Dopamine D1 - antagonists & inhibitors ; Receptors, Dopamine D1 - metabolism ; Receptors, Dopamine D2 - metabolism ; Rodents ; Signal Transduction - drug effects ; Signaling ; Sleep ; Sulpiride ; Sulpiride - pharmacology</subject><ispartof>PloS one, 2015-08, Vol.10 (8), p.e0135578-e0135578</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Lee, Chirwa. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Lee, Chirwa 2015 Lee, Chirwa</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-86a894528b22118fee714c004df0111f88cc03055fe426df3d43f0955884e5983</citedby><cites>FETCH-LOGICAL-c758t-86a894528b22118fee714c004df0111f88cc03055fe426df3d43f0955884e5983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537230/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537230/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26275140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fasano, Alfonso</contributor><creatorcontrib>Lee, Kiera-Nicole</creatorcontrib><creatorcontrib>Chirwa, Sanika</creatorcontrib><title>Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Formation of episodic memories (i.e. remembered experiences) requires a process called consolidation which involves communication between the neocortex and hippocampus. However, the neuromodulatory mechanisms underlying this neocortico-hippocampal communication are poorly understood. Here, we examined the involvement of dopamine D1 receptors (D1R) and D2 receptors (D2R) mediated signaling on memory consolidation using the Novel Object Recognition (NOR) test. We conducted the tests in male Hartley guinea pigs and cognitive behaviors were assessed in customized Phenotyper home cages utilizing Ethovision XT software from Noldus enabled for the 3-point detection system (nose, center of the body, and rear). We found that acute intraperitoneal injections of either 0.25 mg/kg SCH23390 to block D1Rs or 1.0 mg/kg sulpiride to block D2Rs soon after acquisition (which involved familiarization to two similar objects) attenuated subsequent discrimination for novel objects when tested after 5-hours in the NOR test. By contrast guinea pigs treated with saline showed robust discrimination for novel objects indicating normal operational processes undergirding memory consolidation. The data suggests that involvement of dopaminergic signaling is a key post-acquisition factor in modulating memory consolidation in guinea pigs.</description><subject>Animals</subject><subject>Benzazepines - pharmacology</subject><subject>Blocking</subject><subject>Cages</subject><subject>Cognitive ability</subject><subject>Consolidation</subject><subject>Dopamine</subject><subject>Dopamine D1 receptors</subject><subject>Dopamine D2 Receptor Antagonists - pharmacology</subject><subject>Dopamine D2 receptors</subject><subject>Guinea Pigs</subject><subject>Hippocampus</subject><subject>Laboratories</subject><subject>Learning</subject><subject>Male</subject><subject>Mammals</subject><subject>Memory</subject><subject>Memory Consolidation - drug effects</subject><subject>Memory Consolidation - physiology</subject><subject>Molecular weight</subject><subject>Motor Activity - drug effects</subject><subject>Neocortex</subject><subject>Neuromodulation</subject><subject>Neurons</subject><subject>Neurosciences</subject><subject>Nose</subject><subject>Object recognition</subject><subject>Pattern recognition</subject><subject>Pharmacology</subject><subject>Phenotypes</subject><subject>Receptors</subject><subject>Receptors, Dopamine D1 - antagonists & inhibitors</subject><subject>Receptors, Dopamine D1 - metabolism</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Rodents</subject><subject>Signal Transduction - drug effects</subject><subject>Signaling</subject><subject>Sleep</subject><subject>Sulpiride</subject><subject>Sulpiride - pharmacology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01v1DAQhiMEoqXwDxBEQkJw2MWfiXOpVBYoKy0qYoGr5Th21ktiBztB9N_jsGm1QT2gHBy9fuYdzXgmSZ5CsIQ4h2_2bvBWNMvOWbUEEFOas3vJKSwwWmQI4PtH_yfJoxD2AFDMsuxhcoIylFNIwGnC3zZO_jC2Tt-5TrTGKl8bmW5NHb1HeeucTYXulU83Sng7auu2E8aH9JNqnb9OV84G15hK9CayxqaXQ_QR6WdTh8fJAy2aoJ5M51ny7cP7r6uPi83V5Xp1sVnInLJ-wTLBCkIRKxGCkGmlckgkAKTSAEKoGZMSYECpVgRllcYVwRoUlDJGFC0YPkueH3y7xgU-9SZwBAjOGGYQRWJ9ICon9rzzphX-mjth-F_B-ZoL3xvZKF5gLWEJZVVUigANSwIVpAxnEIMyJo5e51O2oWxVJZXtvWhmpvMba3a8dr84oThHGESDV5OBdz8HFXremiBV0wir3BA4zAEdCycj-uIf9O7qJqoWsQBjtYt55WjKLwiiGcxwQSO1vIOKX6VaI-MgaRP1WcDrWUBkevW7r8UQAl9vv_w_e_V9zr48YndKNP0uztAwTlCYg-QASu9C8ErfNhkCPu7BTTf4uAd82oMY9uz4gW6DbgYf_wFODgEN</recordid><startdate>20150814</startdate><enddate>20150814</enddate><creator>Lee, Kiera-Nicole</creator><creator>Chirwa, Sanika</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150814</creationdate><title>Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs</title><author>Lee, Kiera-Nicole ; Chirwa, Sanika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-86a894528b22118fee714c004df0111f88cc03055fe426df3d43f0955884e5983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Benzazepines - pharmacology</topic><topic>Blocking</topic><topic>Cages</topic><topic>Cognitive ability</topic><topic>Consolidation</topic><topic>Dopamine</topic><topic>Dopamine D1 receptors</topic><topic>Dopamine D2 Receptor Antagonists - pharmacology</topic><topic>Dopamine D2 receptors</topic><topic>Guinea Pigs</topic><topic>Hippocampus</topic><topic>Laboratories</topic><topic>Learning</topic><topic>Male</topic><topic>Mammals</topic><topic>Memory</topic><topic>Memory Consolidation - drug effects</topic><topic>Memory Consolidation - physiology</topic><topic>Molecular weight</topic><topic>Motor Activity - drug effects</topic><topic>Neocortex</topic><topic>Neuromodulation</topic><topic>Neurons</topic><topic>Neurosciences</topic><topic>Nose</topic><topic>Object recognition</topic><topic>Pattern recognition</topic><topic>Pharmacology</topic><topic>Phenotypes</topic><topic>Receptors</topic><topic>Receptors, Dopamine D1 - antagonists & inhibitors</topic><topic>Receptors, Dopamine D1 - metabolism</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Rodents</topic><topic>Signal Transduction - drug effects</topic><topic>Signaling</topic><topic>Sleep</topic><topic>Sulpiride</topic><topic>Sulpiride - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kiera-Nicole</creatorcontrib><creatorcontrib>Chirwa, Sanika</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kiera-Nicole</au><au>Chirwa, Sanika</au><au>Fasano, Alfonso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-08-14</date><risdate>2015</risdate><volume>10</volume><issue>8</issue><spage>e0135578</spage><epage>e0135578</epage><pages>e0135578-e0135578</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Formation of episodic memories (i.e. remembered experiences) requires a process called consolidation which involves communication between the neocortex and hippocampus. However, the neuromodulatory mechanisms underlying this neocortico-hippocampal communication are poorly understood. Here, we examined the involvement of dopamine D1 receptors (D1R) and D2 receptors (D2R) mediated signaling on memory consolidation using the Novel Object Recognition (NOR) test. We conducted the tests in male Hartley guinea pigs and cognitive behaviors were assessed in customized Phenotyper home cages utilizing Ethovision XT software from Noldus enabled for the 3-point detection system (nose, center of the body, and rear). We found that acute intraperitoneal injections of either 0.25 mg/kg SCH23390 to block D1Rs or 1.0 mg/kg sulpiride to block D2Rs soon after acquisition (which involved familiarization to two similar objects) attenuated subsequent discrimination for novel objects when tested after 5-hours in the NOR test. By contrast guinea pigs treated with saline showed robust discrimination for novel objects indicating normal operational processes undergirding memory consolidation. The data suggests that involvement of dopaminergic signaling is a key post-acquisition factor in modulating memory consolidation in guinea pigs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26275140</pmid><doi>10.1371/journal.pone.0135578</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Benzazepines - pharmacology Blocking Cages Cognitive ability Consolidation Dopamine Dopamine D1 receptors Dopamine D2 Receptor Antagonists - pharmacology Dopamine D2 receptors Guinea Pigs Hippocampus Laboratories Learning Male Mammals Memory Memory Consolidation - drug effects Memory Consolidation - physiology Molecular weight Motor Activity - drug effects Neocortex Neuromodulation Neurons Neurosciences Nose Object recognition Pattern recognition Pharmacology Phenotypes Receptors Receptors, Dopamine D1 - antagonists & inhibitors Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Rodents Signal Transduction - drug effects Signaling Sleep Sulpiride Sulpiride - pharmacology |
| title | Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs |
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