Impact of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) single nucleotide polymorphisms on outcome in gastroenteropancreatic neuroendocrine neoplasms

Angiogenesis represents a key event in cancer development, leading to local invasion e metastatization, and might be considered a basic feature in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) with a high expression of angiogenic molecules. We aimed to analyze the prognostic and predict...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0197035-e0197035
Hauptverfasser:	Berardi, Rossana, Torniai, Mariangela, Partelli, Stefano, Rubini, Corrado, Pagliaretta, Silvia, Savini, Agnese, Polenta, Vanessa, Santoni, Matteo, Giampieri, Riccardo, Onorati, Sofia, Barucca, Federica, Murrone, Alberto, Bianchi, Francesca, Falconi, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiogenesis Biology and Life Sciences Cancer Cancer therapies Colorectal cancer Deoxyribonucleic acid DNA Female Gene Expression Regulation, Neoplastic Gene frequency Health risks Histopathology Humans Hypoxia Intestinal Neoplasms - genetics Intestinal Neoplasms - mortality Intestinal Neoplasms - pathology Male Medical diagnosis Medicine and Health Sciences Metastasis Middle Aged Molecular chains Neoplasia Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasms Neuroendocrine tumors Neuroendocrine Tumors - genetics Neuroendocrine Tumors - mortality Neuroendocrine Tumors - pathology Neurosciences Pancreas Pancreatic Neoplasms - genetics Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Patients Peripheral blood Polymorphism, Single Nucleotide Population Prognosis Risk assessment Signal transduction Single-nucleotide polymorphism Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach Neoplasms - pathology Survival Rate Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-3 - genetics Vascular endothelial growth factor receptors Young Adult
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