Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study

The need for biomarkers which can predict disease course and treatment response in rheumatoid arthritis (RA) is evident. We explored whether clinical and imaging responses to biologic disease modifying anti-rheumatic drug treatment (bDMARD) were associated with the individual's mediator product...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0197001-e0197001
Hauptverfasser:	Andersen, Martin, Boesen, Mikael, Ellegaard, Karen, Söderström, Kalle, Søe, Niels H, Spee, Pieter, Mørch, Ulrik G W, Torp-Pedersen, Søren, Bartels, Else M, Danneskiold-Samsøe, Bente, Karlsson, Lars, Bliddal, Henning
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Autoimmune diseases Biological treatment Biology and Life Sciences Biomarkers Bone marrow C-reactive protein Care and treatment Cytokines Development and progression Disease control Doppler effect Edema Engineering and Technology Explants Gene expression Genetic aspects Hand surgery Health aspects Immunoassays Immunology Inflammation Interleukin Interleukin 6 Joint surgery Macrophage inflammatory protein Macrophage inflammatory protein 1 Magnetic resonance Magnetic resonance imaging Medical imaging Medical treatment Medicine and Health Sciences Methods Monocyte chemoattractant protein 1 Monocytes NMR Nuclear magnetic resonance Patients Proteins Research and Analysis Methods Rheumatoid arthritis Rheumatology Statistical analysis Statistical methods Surgery TNF inhibitors Tumor necrosis factor-TNF Ultrasonic imaging Ultrasound
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