Cross-talk between human airway epithelial cells and 3T3-J2 feeder cells involves partial activation of human MET by murine HGF

There is considerable interest in the ex vivo propagation of primary human basal epithelial stem/progenitor cells with a view to their use in drug development, toxicity testing and regenerative medicine. These cells can be expanded in co-culture with mitotically inactivated 3T3-J2 murine embryonic f...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0197129
Hauptverfasser:	Hynds, Robert E, Gowers, Kate H C, Nigro, Ersilia, Butler, Colin R, Bonfanti, Paola, Giangreco, Adam, Prêle, Cecilia M, Janes, Sam M
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Asthma Basal cells Biology and Life Sciences Biopsy c-Met protein Cancer Cell Communication Cell culture Cell interactions Cell Line Cells (biology) Coculture Techniques Crick, Francis Crosstalk Cytokines Deactivation Drug development Enzyme Activation Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Feeder Cells - cytology Feeder Cells - metabolism Fibroblasts Grb2 protein Growth factors Hepatocyte growth factor Hepatocyte Growth Factor - metabolism Human behavior Humans Inactivation Kinases Lungs Medicine and Health Sciences Mice Mucous membrane Nuclear transport Phosphorylation Progenitor cells Propagation Protein interaction Proteins Proto-Oncogene Proteins c-met - metabolism Rats Regenerative medicine Respiratory Mucosa - cytology Respiratory Mucosa - metabolism Respiratory tract Stat6 protein STAT6 Transcription Factor - metabolism Stem cells Toxicity testing Transcription Translocation Tumor cell lines Tyrosine
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