Morphophysiological changes in the splenic extracellular matrix of Leishmania infantum-naturally infected dogs is associated with alterations in lymphoid niches and the CD4+ T cell frequency in spleens

The spleen is one of the main affected organs in canine visceral leishmaniasis (CVL). Disorganization of the splenic white pulp (SWP) has been associated with immunosuppression and disease progression. This study aims to assess structural and cellular changes in the splenic extracellular matrix of d...

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Veröffentlicht in:	PLoS neglected tropical diseases 2018-04, Vol.12 (4), p.e0006445-e0006445
Hauptverfasser:	da Silva, Aurea Virginia Andrade, Figueiredo, Fabiano Borges, Menezes, Rodrigo Caldas, Mendes-Junior, Arthur Augusto, de Miranda, Luisa Helena Monteiro, Cupolillo, Elisa, Porrozzi, Renato, Morgado, Fernanda Nazaré
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biology and Life Sciences Body organs CD3 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD8 antigen Cells Cellular structure Chemokines Collagen Cytokines Deposition Development and progression Diseases and pests DNA Dog Diseases - immunology Dog Diseases - parasitology Dog Diseases - pathology Dogs Extracellular Extracellular matrix Extracellular Matrix - immunology Extracellular Matrix - parasitology Extracellular Matrix - pathology Fibronectin Follicles Funding Gelatinase B Genetic aspects Granulomas Histopathology Immunohistochemistry Immunohistochemistry - veterinary Immunosuppression Infections Interleukin 10 Laminin Leishmania Leishmania amazonensis Leishmania infantum Leishmania infantum - immunology Leishmania infantum - physiology Leishmaniasis Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - parasitology Leishmaniasis, Visceral - pathology Leishmaniasis, Visceral - veterinary Lymphocytes Lymphocytes - immunology Lymphocytes - pathology Lymphocytes B Lymphocytes T Medicine and Health Sciences Niches Nucleotide sequence Organizations Organs Parasite Load - veterinary Parasites Parasitic diseases PCR Pulp Spleen Spleen - immunology Spleen - parasitology Spleen - pathology Structure-function relationships Tropical diseases Vector-borne diseases Visceral leishmaniasis White pulp γ-Interferon
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