Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children

Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. The objective of this study was to determine to wha...

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Veröffentlicht in:	PLoS medicine 2018-04, Vol.15 (4), p.e1002548
Hauptverfasser:	Bonifacio, Ezio, Beyerlein, Andreas, Hippich, Markus, Winkler, Christiane, Vehik, Kendra, Weedon, Michael N, Laimighofer, Michael, Hattersley, Andrew T, Krumsiek, Jan, Frohnert, Brigitte I, Steck, Andrea K, Hagopian, William A, Krischer, Jeffrey P, Lernmark, Åke, Rewers, Marian J, She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Oram, Richard A, Rich, Stephen S, Ziegler, Anette-G
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Autoantibodies Autoantibodies - metabolism Autoimmunity Basic Medicine Beta cells Biology and Life Sciences Case-Control Studies Child Child, Preschool Children Clinical Medicine Clinical trials Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Endocrinology and Diabetes Endokrinologi och diabetes Family Female Females Genetic aspects Genetic Predisposition to Disease Genetic Testing Genetics Genotypes Health aspects Health risks Histocompatibility antigen HLA Humans Identification and classification Infant Infant, Newborn Infants Islets of Langerhans - immunology Klinisk medicin Male Males Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicine and Health Sciences Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Neonates Pancreas Pancreatic beta cells People and Places Risk Assessment Risk Factors Sensitivity Sex differences Single-nucleotide polymorphism Type 1 diabetes
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