Endothelium-targeted delivery of dexamethasone by anti-VCAM-1 SAINT-O-Somes in mouse endotoxemia

Microvascular endothelial cells play a pivotal role in the pathogenesis of sepsis-induced inflammatory responses and multiple organ failure. Therefore, they represent an important target for pharmacological intervention in the treatment of sepsis. Glucocorticosteroids were widely used in the treatme...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0196976-e0196976
Hauptverfasser:	Li, Ranran, Kowalski, Piotr S, Morselt, Henriëtte W M, Schepel, Ilona, Jongman, Rianne M, Aslan, Adnan, Ruiters, Marcel H J, Zijlstra, Jan G, Molema, Grietje, van Meurs, Matijs, Kamps, Jan A A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesiology Antibodies Attenuation Biology Biology and Life Sciences Care and treatment Cell activation Cell adhesion Cell adhesion & migration Cell adhesion molecules Critical care Cytokines Dexamethasone Dosage and administration Drug delivery Drug delivery systems Drugs Endothelial cells Endothelium Endotoxemia Gene expression Glucocorticoids Inflammation Kidneys Laboratories Lipopolysaccharides Liposomes Liver Lungs Medicine and Health Sciences Microvasculature Mortality Multiple organ dysfunction syndrome NF-κB protein Organs Pathogenesis Pathology Pharmacology Pyridinium Pyridinium chlorides Research and Analysis Methods Rodents Sepsis Steroids Supervision Vascular cell adhesion molecule 1
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