Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

Bacterial nitroreductases (NTRs) have been widely utilized in the development of novel antibiotics, degradation of pollutants, and gene-directed enzyme prodrug therapy (GDEPT) of cancer that reached clinical trials. In case of GDEPT, since NTR is not naturally present in mammalian cells, the prodrug...

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Veröffentlicht in:	PloS one 2015-06, Vol.10 (6), p.e0131037-e0131037
Hauptverfasser:	Vorobyeva, Anzhelika G, Stanton, Michael, Godinat, Aurélien, Lund, Kjetil B, Karateev, Grigory G, Francis, Kevin P, Allen, Elizabeth, Gelovani, Juri G, McCormack, Emmet, Tangney, Mark, Dubikovskaya, Elena A
Format:	Artikel
Sprache:	eng
Schlagworte:	Advantages Animal models Animals Antibiotics Apoptosis Bacteria Bacterial infections Biodegradation Bioluminescence Cancer Cancer therapies Cell Line Clinical trials Diagnostic Imaging - methods E coli Engineering Environmental degradation Enzymes Escherichia coli Female Genetic Therapy - methods Helicobacter pylori Hematology Humans Hypoxia Imaging Internal medicine Luciferase Luciferin Luminescent Measurements - methods Mammalian cells Medical research Medicine Mice Mice, Inbred BALB C Neoplasms - diagnosis Nitroreductase Nitroreductases - metabolism Pollutants Prodrugs - pharmacology Quantum dots Therapy Tumors Xenografts Xenotransplantation
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