Visual vs Fully Automatic Histogram-Based Assessment of Idiopathic Pulmonary Fibrosis (IPF) Progression Using Sequential Multidetector Computed Tomography (MDCT)
To describe changes over time in extent of idiopathic pulmonary fibrosis (IPF) at multidetector computed tomography (MDCT) assessed by semi-quantitative visual scores (VSs) and fully automatic histogram-based quantitative evaluation and to test the relationship between these two methods of quantific...
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| creator | Colombi, Davide Dinkel, Julien Weinheimer, Oliver Obermayer, Berenike Buzan, Teodora Nabers, Diana Bauer, Claudia Oltmanns, Ute Palmowski, Karin Herth, Felix Kauczor, Hans Ulrich Sverzellati, Nicola Kreuter, Michael Heussel, Claus Peter |
| description | To describe changes over time in extent of idiopathic pulmonary fibrosis (IPF) at multidetector computed tomography (MDCT) assessed by semi-quantitative visual scores (VSs) and fully automatic histogram-based quantitative evaluation and to test the relationship between these two methods of quantification.
Forty IPF patients (median age: 70 y, interquartile: 62-75 years; M:F, 33:7) that underwent 2 MDCT at different time points with a median interval of 13 months (interquartile: 10-17 months) were retrospectively evaluated. In-house software YACTA quantified automatically lung density histogram (10th-90th percentile in 5th percentile steps). Longitudinal changes in VSs and in the percentiles of attenuation histogram were obtained in 20 untreated patients and 20 patients treated with pirfenidone. Pearson correlation analysis was used to test the relationship between VSs and selected percentiles.
In follow-up MDCT, visual overall extent of parenchymal abnormalities (OE) increased in median by 5%/year (interquartile: 0%/y; +11%/y). Substantial difference was found between treated and untreated patients in HU changes of the 40th and of the 80th percentiles of density histogram. Correlation analysis between VSs and selected percentiles showed higher correlation between the changes (Δ) in OE and Δ 40th percentile (r=0.69; p |
| doi_str_mv | 10.1371/journal.pone.0130653 |
| format | Article |
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Forty IPF patients (median age: 70 y, interquartile: 62-75 years; M:F, 33:7) that underwent 2 MDCT at different time points with a median interval of 13 months (interquartile: 10-17 months) were retrospectively evaluated. In-house software YACTA quantified automatically lung density histogram (10th-90th percentile in 5th percentile steps). Longitudinal changes in VSs and in the percentiles of attenuation histogram were obtained in 20 untreated patients and 20 patients treated with pirfenidone. Pearson correlation analysis was used to test the relationship between VSs and selected percentiles.
In follow-up MDCT, visual overall extent of parenchymal abnormalities (OE) increased in median by 5%/year (interquartile: 0%/y; +11%/y). Substantial difference was found between treated and untreated patients in HU changes of the 40th and of the 80th percentiles of density histogram. Correlation analysis between VSs and selected percentiles showed higher correlation between the changes (Δ) in OE and Δ 40th percentile (r=0.69; p<0.001) as compared to Δ 80th percentile (r=0.58; p<0.001); closer correlation was found between Δ ground-glass extent and Δ 40th percentile (r=0.66, p<0.001) as compared to Δ 80th percentile (r=0.47, p=0.002), while the Δ reticulations correlated better with the Δ 80th percentile (r=0.56, p<0.001) in comparison to Δ 40th percentile (r=0.43, p=0.003).
There is a relevant and fully automatically measurable difference at MDCT in VSs and in histogram analysis at one year follow-up of IPF patients, whether treated or untreated: Δ 40th percentile might reflect the change in overall extent of lung abnormalities, notably of ground-glass pattern; furthermore Δ 80th percentile might reveal the course of reticular opacities.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0130653</identifier><identifier>PMID: 26110421</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Aged ; Attenuation ; CAT scans ; Chronic obstructive pulmonary disease ; Computation ; Computed tomography ; Correlation ; Correlation analysis ; Critical care ; Development and progression ; Disease Progression ; Emphysema ; Female ; Fibrosis ; Humans ; Idiopathic Pulmonary Fibrosis - diagnostic imaging ; Idiopathic Pulmonary Fibrosis - drug therapy ; Lung - diagnostic imaging ; Lung diseases ; Male ; Medical imaging ; Medical research ; Medicine ; Middle Aged ; Multidetector Computed Tomography - methods ; Patients ; Pneumonia ; Pulmonary fibrosis ; Pyridones - therapeutic use ; Quantitative analysis ; Respiratory tract diseases ; Retrospective Studies ; Skewness ; Treatment Outcome</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0130653-e0130653</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Colombi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Colombi et al 2015 Colombi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c605t-e785110181aa02284a0607727aa1dfcea7e7f0964c3552fd5c7ba0038c81134d3</citedby><cites>FETCH-LOGICAL-c605t-e785110181aa02284a0607727aa1dfcea7e7f0964c3552fd5c7ba0038c81134d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482435/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482435/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26110421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hare, Joshua M.</contributor><creatorcontrib>Colombi, Davide</creatorcontrib><creatorcontrib>Dinkel, Julien</creatorcontrib><creatorcontrib>Weinheimer, Oliver</creatorcontrib><creatorcontrib>Obermayer, Berenike</creatorcontrib><creatorcontrib>Buzan, Teodora</creatorcontrib><creatorcontrib>Nabers, Diana</creatorcontrib><creatorcontrib>Bauer, Claudia</creatorcontrib><creatorcontrib>Oltmanns, Ute</creatorcontrib><creatorcontrib>Palmowski, Karin</creatorcontrib><creatorcontrib>Herth, Felix</creatorcontrib><creatorcontrib>Kauczor, Hans Ulrich</creatorcontrib><creatorcontrib>Sverzellati, Nicola</creatorcontrib><creatorcontrib>Kreuter, Michael</creatorcontrib><creatorcontrib>Heussel, Claus Peter</creatorcontrib><title>Visual vs Fully Automatic Histogram-Based Assessment of Idiopathic Pulmonary Fibrosis (IPF) Progression Using Sequential Multidetector Computed Tomography (MDCT)</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To describe changes over time in extent of idiopathic pulmonary fibrosis (IPF) at multidetector computed tomography (MDCT) assessed by semi-quantitative visual scores (VSs) and fully automatic histogram-based quantitative evaluation and to test the relationship between these two methods of quantification.
Forty IPF patients (median age: 70 y, interquartile: 62-75 years; M:F, 33:7) that underwent 2 MDCT at different time points with a median interval of 13 months (interquartile: 10-17 months) were retrospectively evaluated. In-house software YACTA quantified automatically lung density histogram (10th-90th percentile in 5th percentile steps). Longitudinal changes in VSs and in the percentiles of attenuation histogram were obtained in 20 untreated patients and 20 patients treated with pirfenidone. Pearson correlation analysis was used to test the relationship between VSs and selected percentiles.
In follow-up MDCT, visual overall extent of parenchymal abnormalities (OE) increased in median by 5%/year (interquartile: 0%/y; +11%/y). Substantial difference was found between treated and untreated patients in HU changes of the 40th and of the 80th percentiles of density histogram. Correlation analysis between VSs and selected percentiles showed higher correlation between the changes (Δ) in OE and Δ 40th percentile (r=0.69; p<0.001) as compared to Δ 80th percentile (r=0.58; p<0.001); closer correlation was found between Δ ground-glass extent and Δ 40th percentile (r=0.66, p<0.001) as compared to Δ 80th percentile (r=0.47, p=0.002), while the Δ reticulations correlated better with the Δ 80th percentile (r=0.56, p<0.001) in comparison to Δ 40th percentile (r=0.43, p=0.003).
There is a relevant and fully automatically measurable difference at MDCT in VSs and in histogram analysis at one year follow-up of IPF patients, whether treated or untreated: Δ 40th percentile might reflect the change in overall extent of lung abnormalities, notably of ground-glass pattern; furthermore Δ 80th percentile might reveal the course of reticular opacities.</description><subject>Abnormalities</subject><subject>Aged</subject><subject>Attenuation</subject><subject>CAT scans</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Computation</subject><subject>Computed tomography</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Critical care</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Emphysema</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis - diagnostic imaging</subject><subject>Idiopathic Pulmonary Fibrosis - drug therapy</subject><subject>Lung - diagnostic imaging</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Multidetector Computed Tomography - methods</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Pulmonary fibrosis</subject><subject>Pyridones - therapeutic use</subject><subject>Quantitative analysis</subject><subject>Respiratory tract diseases</subject><subject>Retrospective Studies</subject><subject>Skewness</subject><subject>Treatment 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vs Fully Automatic Histogram-Based Assessment of Idiopathic Pulmonary Fibrosis (IPF) Progression Using Sequential Multidetector Computed Tomography (MDCT)</title><author>Colombi, Davide ; Dinkel, Julien ; Weinheimer, Oliver ; Obermayer, Berenike ; Buzan, Teodora ; Nabers, Diana ; Bauer, Claudia ; Oltmanns, Ute ; Palmowski, Karin ; Herth, Felix ; Kauczor, Hans Ulrich ; Sverzellati, Nicola ; Kreuter, Michael ; Heussel, Claus Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c605t-e785110181aa02284a0607727aa1dfcea7e7f0964c3552fd5c7ba0038c81134d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abnormalities</topic><topic>Aged</topic><topic>Attenuation</topic><topic>CAT scans</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Computation</topic><topic>Computed tomography</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Critical care</topic><topic>Development and progression</topic><topic>Disease Progression</topic><topic>Emphysema</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Humans</topic><topic>Idiopathic Pulmonary Fibrosis - diagnostic imaging</topic><topic>Idiopathic Pulmonary Fibrosis - drug therapy</topic><topic>Lung - diagnostic imaging</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Multidetector Computed Tomography - methods</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Pulmonary fibrosis</topic><topic>Pyridones - therapeutic use</topic><topic>Quantitative analysis</topic><topic>Respiratory tract diseases</topic><topic>Retrospective Studies</topic><topic>Skewness</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Colombi, Davide</creatorcontrib><creatorcontrib>Dinkel, 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Colombi, Davide</au><au>Dinkel, Julien</au><au>Weinheimer, Oliver</au><au>Obermayer, Berenike</au><au>Buzan, Teodora</au><au>Nabers, Diana</au><au>Bauer, Claudia</au><au>Oltmanns, Ute</au><au>Palmowski, Karin</au><au>Herth, Felix</au><au>Kauczor, Hans Ulrich</au><au>Sverzellati, Nicola</au><au>Kreuter, Michael</au><au>Heussel, Claus Peter</au><au>Hare, Joshua M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Visual vs Fully Automatic Histogram-Based Assessment of Idiopathic Pulmonary Fibrosis (IPF) Progression Using Sequential Multidetector Computed Tomography (MDCT)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-25</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0130653</spage><epage>e0130653</epage><pages>e0130653-e0130653</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To describe changes over time in extent of idiopathic pulmonary fibrosis (IPF) at multidetector computed tomography (MDCT) assessed by semi-quantitative visual scores (VSs) and fully automatic histogram-based quantitative evaluation and to test the relationship between these two methods of quantification.
Forty IPF patients (median age: 70 y, interquartile: 62-75 years; M:F, 33:7) that underwent 2 MDCT at different time points with a median interval of 13 months (interquartile: 10-17 months) were retrospectively evaluated. In-house software YACTA quantified automatically lung density histogram (10th-90th percentile in 5th percentile steps). Longitudinal changes in VSs and in the percentiles of attenuation histogram were obtained in 20 untreated patients and 20 patients treated with pirfenidone. Pearson correlation analysis was used to test the relationship between VSs and selected percentiles.
In follow-up MDCT, visual overall extent of parenchymal abnormalities (OE) increased in median by 5%/year (interquartile: 0%/y; +11%/y). Substantial difference was found between treated and untreated patients in HU changes of the 40th and of the 80th percentiles of density histogram. Correlation analysis between VSs and selected percentiles showed higher correlation between the changes (Δ) in OE and Δ 40th percentile (r=0.69; p<0.001) as compared to Δ 80th percentile (r=0.58; p<0.001); closer correlation was found between Δ ground-glass extent and Δ 40th percentile (r=0.66, p<0.001) as compared to Δ 80th percentile (r=0.47, p=0.002), while the Δ reticulations correlated better with the Δ 80th percentile (r=0.56, p<0.001) in comparison to Δ 40th percentile (r=0.43, p=0.003).
There is a relevant and fully automatically measurable difference at MDCT in VSs and in histogram analysis at one year follow-up of IPF patients, whether treated or untreated: Δ 40th percentile might reflect the change in overall extent of lung abnormalities, notably of ground-glass pattern; furthermore Δ 80th percentile might reveal the course of reticular opacities.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26110421</pmid><doi>10.1371/journal.pone.0130653</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-06, Vol.10 (6), p.e0130653-e0130653 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2038643072 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Aged Attenuation CAT scans Chronic obstructive pulmonary disease Computation Computed tomography Correlation Correlation analysis Critical care Development and progression Disease Progression Emphysema Female Fibrosis Humans Idiopathic Pulmonary Fibrosis - diagnostic imaging Idiopathic Pulmonary Fibrosis - drug therapy Lung - diagnostic imaging Lung diseases Male Medical imaging Medical research Medicine Middle Aged Multidetector Computed Tomography - methods Patients Pneumonia Pulmonary fibrosis Pyridones - therapeutic use Quantitative analysis Respiratory tract diseases Retrospective Studies Skewness Treatment Outcome |
| title | Visual vs Fully Automatic Histogram-Based Assessment of Idiopathic Pulmonary Fibrosis (IPF) Progression Using Sequential Multidetector Computed Tomography (MDCT) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-01T12%3A30%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Visual%20vs%20Fully%20Automatic%20Histogram-Based%20Assessment%20of%20Idiopathic%20Pulmonary%20Fibrosis%20(IPF)%20Progression%20Using%20Sequential%20Multidetector%20Computed%20Tomography%20(MDCT)&rft.jtitle=PloS%20one&rft.au=Colombi,%20Davide&rft.date=2015-06-25&rft.volume=10&rft.issue=6&rft.spage=e0130653&rft.epage=e0130653&rft.pages=e0130653-e0130653&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0130653&rft_dat=%3Cgale_plos_%3EA419357216%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1691276487&rft_id=info:pmid/26110421&rft_galeid=A419357216&rft_doaj_id=oai_doaj_org_article_ae8637b3e1ed44f1bffa5285bc5817a8&rfr_iscdi=true |