Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day
In mammals, a light-entrainable clock located in the suprachiasmatic nucleus (SCN) regulates circadian rhythms by synchronizing oscillators throughout the brain and body. Notably, the nature of the relation between the SCN clock and subordinate oscillators in the rest of the brain is not well define...
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| creator | Harbour, Valerie L Weigl, Yuval Robinson, Barry Amir, Shimon |
| description | In mammals, a light-entrainable clock located in the suprachiasmatic nucleus (SCN) regulates circadian rhythms by synchronizing oscillators throughout the brain and body. Notably, the nature of the relation between the SCN clock and subordinate oscillators in the rest of the brain is not well defined. We performed a high temporal resolution analysis of the expression of the circadian clock protein PERIOD2 (PER2) in the rat forebrain to characterize the distribution, amplitude and phase of PER2 rhythms across different regions. Eighty-four LEW/Crl male rats were entrained to a 12-h: 12-h light/dark cycle, and subsequently perfused every 30 min across the 24-h day for a total of 48 time-points. PER2 expression was assessed with immunohistochemistry and analyzed using automated cell counts. We report the presence of PER2 expression in 20 forebrain areas important for a wide range of motivated and appetitive behaviors including the SCN, bed nucleus, and several regions of the amygdala, hippocampus, striatum, and cortex. Eighteen areas displayed significant PER2 rhythms, which peaked at different times of day. Our data demonstrate a previously uncharacterized regional distribution of rhythms of a clock protein expression in the brain that provides a sound basis for future studies of circadian clock function in animal models of disease. |
| doi_str_mv | 10.1371/journal.pone.0076391 |
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Notably, the nature of the relation between the SCN clock and subordinate oscillators in the rest of the brain is not well defined. We performed a high temporal resolution analysis of the expression of the circadian clock protein PERIOD2 (PER2) in the rat forebrain to characterize the distribution, amplitude and phase of PER2 rhythms across different regions. Eighty-four LEW/Crl male rats were entrained to a 12-h: 12-h light/dark cycle, and subsequently perfused every 30 min across the 24-h day for a total of 48 time-points. PER2 expression was assessed with immunohistochemistry and analyzed using automated cell counts. We report the presence of PER2 expression in 20 forebrain areas important for a wide range of motivated and appetitive behaviors including the SCN, bed nucleus, and several regions of the amygdala, hippocampus, striatum, and cortex. Eighteen areas displayed significant PER2 rhythms, which peaked at different times of day. Our data demonstrate a previously uncharacterized regional distribution of rhythms of a clock protein expression in the brain that provides a sound basis for future studies of circadian clock function in animal models of disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0076391</identifier><identifier>PMID: 24124556</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amygdala ; Amygdala - metabolism ; Animal diseases ; Animal models ; Animals ; Biological clocks ; Brain ; Cerebral Cortex - metabolism ; Circadian rhythm ; Circadian Rhythm - physiology ; Circadian rhythms ; CLOCK protein ; Cortex (temporal) ; Entrainment ; Forebrain ; Hippocampus - metabolism ; Immunohistochemistry ; Male ; Neostriatum ; Neurosciences ; Oscillators ; Peptide mapping ; Period 2 protein ; Period Circadian Proteins - metabolism ; Prosencephalon - metabolism ; Proteins ; Rats ; Rodents ; Septal Nuclei - metabolism ; Suprachiasmatic nucleus ; Suprachiasmatic Nucleus - metabolism ; Synchronism ; Temporal lobe ; Temporal resolution</subject><ispartof>PloS one, 2013-10, Vol.8 (10), p.e76391-e76391</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Harbour et al. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harbour, Valerie L</au><au>Weigl, Yuval</au><au>Robinson, Barry</au><au>Amir, Shimon</au><au>Mongrain, Valérie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-10-04</date><risdate>2013</risdate><volume>8</volume><issue>10</issue><spage>e76391</spage><epage>e76391</epage><pages>e76391-e76391</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In mammals, a light-entrainable clock located in the suprachiasmatic nucleus (SCN) regulates circadian rhythms by synchronizing oscillators throughout the brain and body. Notably, the nature of the relation between the SCN clock and subordinate oscillators in the rest of the brain is not well defined. We performed a high temporal resolution analysis of the expression of the circadian clock protein PERIOD2 (PER2) in the rat forebrain to characterize the distribution, amplitude and phase of PER2 rhythms across different regions. Eighty-four LEW/Crl male rats were entrained to a 12-h: 12-h light/dark cycle, and subsequently perfused every 30 min across the 24-h day for a total of 48 time-points. PER2 expression was assessed with immunohistochemistry and analyzed using automated cell counts. We report the presence of PER2 expression in 20 forebrain areas important for a wide range of motivated and appetitive behaviors including the SCN, bed nucleus, and several regions of the amygdala, hippocampus, striatum, and cortex. Eighteen areas displayed significant PER2 rhythms, which peaked at different times of day. Our data demonstrate a previously uncharacterized regional distribution of rhythms of a clock protein expression in the brain that provides a sound basis for future studies of circadian clock function in animal models of disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24124556</pmid><doi>10.1371/journal.pone.0076391</doi><tpages>e76391</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amygdala Amygdala - metabolism Animal diseases Animal models Animals Biological clocks Brain Cerebral Cortex - metabolism Circadian rhythm Circadian Rhythm - physiology Circadian rhythms CLOCK protein Cortex (temporal) Entrainment Forebrain Hippocampus - metabolism Immunohistochemistry Male Neostriatum Neurosciences Oscillators Peptide mapping Period 2 protein Period Circadian Proteins - metabolism Prosencephalon - metabolism Proteins Rats Rodents Septal Nuclei - metabolism Suprachiasmatic nucleus Suprachiasmatic Nucleus - metabolism Synchronism Temporal lobe Temporal resolution |
| title | Comprehensive mapping of regional expression of the clock protein PERIOD2 in rat forebrain across the 24-h day |
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