Fluctuating vs. continuous exposure to H₂O₂: the effects on mitochondrial membrane potential, intracellular calcium, and NF-κB in astroglia

The effects of H2O2 are widely studied in cell cultures and other in vitro systems. However, such investigations are performed with the assumption that H2O2 concentration is constant, which may not properly reflect in vivo settings, particularly in redox-turbulent microenvironments such as mitochond...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76383
Hauptverfasser:	Bajić, Aleksandar, Spasić, Mihajlo, Andjus, Pavle R, Savić, Danijela, Parabucki, Ana, Nikolić-Kokić, Aleksandra, Spasojević, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Triphosphate - metabolism Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism ATP Calcium Calcium (intracellular) Calcium (mitochondrial) Calcium - metabolism Calcium content Cell culture Cell Line, Tumor Cell Nucleolus - metabolism Electron transport Electron transport chain Experiments Exposure Fluctuations Gene expression Hydrogen peroxide Hydrogen Peroxide - pharmacology Hyperpolarization Intracellular Intracellular Space - metabolism Kinases Lasers Membrane potential Membrane Potential, Mitochondrial - drug effects Microenvironments Microscopy Mitochondria Mitochondria - drug effects Mitochondria - metabolism Neurobiology Neurosciences NF-kappa B - metabolism NF-κB protein Oxidative Stress Physiological effects Physiology Primary Cell Culture Protein Transport Rats Rodents Shear stress Shear stresses Sulfhydryl Compounds - metabolism Superoxide Turbulent flow
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