The Nociceptin/Orphanin FQ system is modulated in patients admitted to ICU with sepsis and after cardiopulmonary bypass

Nociceptin/Orphanin FQ (N/OFQ) is a non-classical endogenous opioid peptide that modulates immune function in vitro. Its importance in inflammation and human sepsis is unknown. The objectives of this study were to determine the relationship between N/OFQ, transcripts for its precursor (pre-pro-N/OFQ...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e76682-e76682
Hauptverfasser:	Thompson, Jonathan P, Serrano-Gomez, Alcira, McDonald, John, Ladak, Nadia, Bowrey, Sarah, Lambert, David G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bypasses Cardiopulmonary Bypass - adverse effects Case-Control Studies Coronary artery bypass Critical Care Cytokines Cytokines - blood Cytokines - metabolism Enzyme-linked immunosorbent assay Female Gene Expression Regulation Heart Heart diseases Heart surgery Histamine Hospital patients Humans Hypotheses Immune response Infection Infections Inflammation Intensive care Intensive Care Units Interleukin 10 Interleukin 8 Lymphocytes Male Medical research Medicine Middle Aged Mortality Narcotics Nociceptin Observational studies Opioid Peptides - genetics Opioid Peptides - metabolism Opioids Pain management Patients Peptides Postoperative Complications Radioimmunoassay Receptors, Opioid - genetics Receptors, Opioid - metabolism Recovery RNA RNA, Messenger - genetics Sepsis Sepsis - etiology Sepsis - metabolism Sepsis - therapy Surgery Thompson, David Time Factors Tumor necrosis factor-TNF Tumor necrosis factor-α
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