Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia

Sleep-disordered breathing with recurrent apnea produces chronic intermittent hypoxia (IH). We previously reported that IH leads to down-regulation of HIF-2α protein via a calpain-dependent signaling pathway resulting in oxidative stress. In the present study, we delineated the signaling pathways as...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e75838-e75838
Hauptverfasser:	Nanduri, Jayasri, Vaddi, Damodara Reddy, Khan, Shakil A, Wang, Ning, Makerenko, Vladislav, Prabhakar, Nanduri R
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adrenal medulla Allopurinol Animals Apnea Basic Helix-Loop-Helix Transcription Factors - metabolism Biology Biotechnology Breathing C-Terminus Calpain Cell culture Cell Hypoxia - physiology Degradation Enzymes Experiments Hypertension Hypoxia Hypoxia-inducible factors Immunoblotting Inflammation Ischemia Male N-Terminus Oxidative stress Oxygen PC12 Cells Pharmacology Pheochromocytoma cells Physiology Proteins Proteolysis Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Rodents Signal transduction Signaling Sleep Sleep disorders Xanthine Xanthine dehydrogenase Xanthine oxidase Xanthine Oxidase - metabolism
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