Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents

Modulation of the DNA repair pathway is an emerging target for the development of anticancer drugs. DNA interstrand cross-links (ICLs), one of the most severe forms of DNA damage caused by anticancer drugs such as cisplatin and mitomycin C (MMC), activates the Fanconi anemia (FA)/BRCA DNA repair pat...

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Veröffentlicht in:	PloS one 2013-10, Vol.8 (10), p.e75905
Hauptverfasser:	Jun, Dong Wha, Hwang, Mihwa, Kim, Hyun Jung, Hwang, Soo Kyung, Kim, Sunshin, Lee, Chang-Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Anticancer properties Antineoplastic agents Antineoplastic drugs Antitumor agents Apoptosis Blotting, Western Calcium Calcium ions Cancer therapies Cancer treatment Cardiovascular diseases Cell cycle Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects Chemosensitization Chemotherapy Cisplatin Cisplatin - pharmacology Colorectal cancer Coronary artery disease Crosslinking Cytotoxicity Deoxyribonucleic acid Digoxin DNA DNA damage DNA repair Drug development Drug resistance Drugs Enzymes Fanconi Anemia - metabolism Fanconi syndrome Fanconi's anemia Fluorescent Antibody Technique Gene expression Glycosides Heart Heart diseases Humans Inhibition Kinases Lesions MAP kinase Medical screening Mitomycin - pharmacology Mitomycin C Molecular biology Molecular chains mRNA Multiple myeloma Na+/K+-exchanging ATPase Ouabain Ouabain - pharmacology Prostate Proteins Repair RNA Signal transduction Signal Transduction - drug effects Sodium-Potassium-Exchanging ATPase - metabolism Tumor cells Ubiquitination
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