An ambient temperature-stable antitoxin of nine co-formulated antibodies for botulism caused by serotypes A, B and E

Safe and effective antitoxins to treat and prevent botulism are needed for biodefense. We have developed recombinant antibody-based therapeutics for botulinum neurotoxin (BoNT) serotypes A, B, and E. The mechanism of action of this antitoxin requires that three mAbs bind one toxin molecule to achiev...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0197011
Hauptverfasser:	Li, Mingxiang, Lee, Dennis, Obi, Chidi R, Freeberg, Joel K, Farr-Jones, Shauna, Tomic, Milan T
Format:	Artikel
Sprache:	eng
Schlagworte:	Ambient temperature Antibodies Antibodies, Bacterial - chemistry Antibodies, Bacterial - immunology Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antitoxins Binding Biology and Life Sciences Botulinum Antitoxin - chemistry Botulinum Antitoxin - immunology Botulinum toxin Botulinum Toxins - antagonists & inhibitors Botulinum Toxins - chemistry Botulinum Toxins - immunology Botulinum Toxins, Type A - antagonists & inhibitors Botulinum Toxins, Type A - chemistry Botulinum Toxins, Type A - immunology Botulism Botulism - drug therapy Botulism - immunology Cancer Care and treatment Enzyme-linked immunosorbent assay Feasibility studies Food contamination Hot Temperature Humans Immunoglobulins Immunotherapy Intoxication Isoforms Medical research Medicine and Health Sciences Molecular chains Monoclonal antibodies Neurotoxins Powder Protein Stability Proteins Recombinant molecules Research and Analysis Methods Serotypes Temperature Toxins Water-borne diseases Waterborne diseases Yeast
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