Tetracyclines function as dual-action light-activated antibiotics

Antimicrobial photodynamic inactivation (aPDI) employs photosensitizing dyes activated by visible light to produce reactive oxygen species. aPDI is independent of the antibiotic resistance status of the target cells, and is thought unlikely to produce resistance itself. Among many PS that have been...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0196485-e0196485
Hauptverfasser:	He, Ya, Huang, Ying-Ying, Xi, Liyan, Gelfand, Jeffrey A, Hamblin, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Bacteria Binding sites Biology and Life Sciences Deactivation Demeclocycline Dermatology Dosage and administration Doxycycline Drug resistance Drug Resistance, Bacterial - drug effects Drug therapy E coli Escherichia coli Escherichia coli - drug effects Escherichia coli - metabolism Escherichia coli infections Inactivation Light Medicine and Health Sciences Methicillin Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - metabolism Methylene blue Methylene Blue - pharmacology Microbial drug resistance Microbial Sensitivity Tests - methods Microorganisms Minimum inhibitory concentration Oxygen Photochemotherapy - methods Photodynamic therapy Photosensitization Photosensitizing Agents - pharmacology Physical sciences Protein synthesis Reactive oxygen species Reactive Oxygen Species - metabolism Regrowth Research and Analysis Methods Ribosomes Ribosomes - drug effects Staphylococcus aureus Staphylococcus infections Tetracyclines Tetracyclines - pharmacology Ultraviolet radiation
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