Microvascular retinopathy and angiographically-demonstrated coronary artery disease: A cross-sectional, observational study
Epidemiological studies suggest retinal microvascular abnormalities predict cardiac events. This study examined microvascular features associated with coronary artery abnormalities. This was a single-centre, cross-sectional, observational study of 144 consecutive subjects undergoing coronary angiogr...
Gespeichert in:
| Veröffentlicht in: | PloS one 2018-05, Vol.13 (5), p.e0192350-e0192350 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0192350 |
|---|---|
| container_issue | 5 |
| container_start_page | e0192350 |
| container_title | PloS one |
| container_volume | 13 |
| creator | Cheng, Lisa Barlis, Peter Gibson, Joel Colville, Deb Hutchinson, Anastasia Gleeson, Geoff Lamoureux, Ecosse VanGaal, William Savige, Judy |
| description | Epidemiological studies suggest retinal microvascular abnormalities predict cardiac events. This study examined microvascular features associated with coronary artery abnormalities. This was a single-centre, cross-sectional, observational study of 144 consecutive subjects undergoing coronary angiography for clinical indications. Their angiograms were deidentified and graded for disease (Leaman score, LAD stenosis ≥ 70%, number of vessels stenosed ≥ 70%), and Thrombolysis in Myocardial Infarction (TIMI) blush score. Subjects also underwent retinal photography (KOWA non-mydriatic camera, Japan), and their deidentified retinal images were graded for hypertensive microvascular retinopathy (Wong and Mitchell classification), vessel calibre using a computer-assisted method (IVAN, U Wisconsin), and diabetic retinopathy (modified Airlie House scheme) independently by a trained grader and an ophthalmologist. Retinal abnormalities were compared between subjects with high and low angiography scores using one way ANOVA, Chi squared and logistic regression analysis (StataCorp, Texas). Subjects had a mean age of 61 years (range 32-88), and included 101 males (70%). Seventeen (12%) had Leaman scores > 10.5, 46 (32%) had LAD stenosis, 13 (9%) had ≥ 3 arteries stenosed, and 20 (14%) had TIMI blush scores < 1. Twenty-six subjects (18%) had a retinal hemorrhage, and 115 (74%) a mild or moderate hypertensive retinopathy. Fifty-five (38%) had diabetes, and 24 (17%) a background (n = 20) or proliferative (n = 4) diabetic retinopathy. A retinal hemorrhage (p = 0.046), moderate microvascular retinopathy (p = 0.08) and proliferative diabetic retinopathy (p = 0.04) were all associated with a higher Leaman score. Venular calibre was increased with triple vessel disease (205.7 ± 21.6 μm, and 193.7 ± 22.3 μm in normals, p = 0.03). Diabetic retinopathy correlated with an increased TIMI blush score (p = 0.01). Retinal microvascular imaging warrants further evaluation in identifying the presence, extent and nature of coronary artery disease. |
| doi_str_mv | 10.1371/journal.pone.0192350 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2036430086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A537798617</galeid><doaj_id>oai_doaj_org_article_47091b8762e54dbb96770f4ca96b3635</doaj_id><sourcerecordid>A537798617</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-c294ab5879db59b14770599cd996227923b5d67dc4a2a296b8b16d36ffef06eb3</originalsourceid><addsrcrecordid>eNqNk1uL1DAUx4so7rr6DUQLgijYMU3apPFBGBYvAysL3l5Dbp3JkmnGpB0c_PKe2ekuU9kHKSVp-jv_k3PLsqclmpWElW-vwhA76Web0NkZKjkmNbqXnZac4IJiRO4f7U-yRyldIVSThtKH2QnmjDR1hU-zP1-cjmErkx68jHm0vevCRvarXS47A-_ShWWUm5XT0vtdYew6dKmPsrcm1yGGTkZAY29hMS5Zmey7fJ6DaEpFsrp3gPg3eVDJxq08fOapH8zucfaglT7ZJ-N6lv34-OH7-efi4vLT4nx-UWjKcV9ozCup6oZxo2quyooxVHOuDecUYwaBq9pQZnQlscScqkaV1BDatrZF1Cpylj0_6G58SGLMWxKQF1oRhBoKxOJAmCCvxCa6NUQlgnTi-iDEpYAQnfZWVAzxUjWMYltXRilO4TptpSU4JpTUoPV-9DaotTXadpAtPxGd_uncSizDVtS8gjISEHg1CsTwa7CpF2uXtPVedjYMh3uzhnKEAX3xD3p3dCO1lBCA69oAfvVeVMxrwhhvaMmAmt1BwQMldxqarHVwPjF4PTEApre_-6UcUhKLb1__n738OWVfHrErK32_SsEP-9ZJU7A6gNfNFm17m-QSif2M3GRD7GdEjDMCZs-OC3RrdDMU5C9sHQ5-</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2036430086</pqid></control><display><type>article</type><title>Microvascular retinopathy and angiographically-demonstrated coronary artery disease: A cross-sectional, observational study</title><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Cheng, Lisa ; Barlis, Peter ; Gibson, Joel ; Colville, Deb ; Hutchinson, Anastasia ; Gleeson, Geoff ; Lamoureux, Ecosse ; VanGaal, William ; Savige, Judy</creator><contributor>Malik, Rayaz A.</contributor><creatorcontrib>Cheng, Lisa ; Barlis, Peter ; Gibson, Joel ; Colville, Deb ; Hutchinson, Anastasia ; Gleeson, Geoff ; Lamoureux, Ecosse ; VanGaal, William ; Savige, Judy ; Malik, Rayaz A.</creatorcontrib><description>Epidemiological studies suggest retinal microvascular abnormalities predict cardiac events. This study examined microvascular features associated with coronary artery abnormalities. This was a single-centre, cross-sectional, observational study of 144 consecutive subjects undergoing coronary angiography for clinical indications. Their angiograms were deidentified and graded for disease (Leaman score, LAD stenosis ≥ 70%, number of vessels stenosed ≥ 70%), and Thrombolysis in Myocardial Infarction (TIMI) blush score. Subjects also underwent retinal photography (KOWA non-mydriatic camera, Japan), and their deidentified retinal images were graded for hypertensive microvascular retinopathy (Wong and Mitchell classification), vessel calibre using a computer-assisted method (IVAN, U Wisconsin), and diabetic retinopathy (modified Airlie House scheme) independently by a trained grader and an ophthalmologist. Retinal abnormalities were compared between subjects with high and low angiography scores using one way ANOVA, Chi squared and logistic regression analysis (StataCorp, Texas). Subjects had a mean age of 61 years (range 32-88), and included 101 males (70%). Seventeen (12%) had Leaman scores > 10.5, 46 (32%) had LAD stenosis, 13 (9%) had ≥ 3 arteries stenosed, and 20 (14%) had TIMI blush scores < 1. Twenty-six subjects (18%) had a retinal hemorrhage, and 115 (74%) a mild or moderate hypertensive retinopathy. Fifty-five (38%) had diabetes, and 24 (17%) a background (n = 20) or proliferative (n = 4) diabetic retinopathy. A retinal hemorrhage (p = 0.046), moderate microvascular retinopathy (p = 0.08) and proliferative diabetic retinopathy (p = 0.04) were all associated with a higher Leaman score. Venular calibre was increased with triple vessel disease (205.7 ± 21.6 μm, and 193.7 ± 22.3 μm in normals, p = 0.03). Diabetic retinopathy correlated with an increased TIMI blush score (p = 0.01). Retinal microvascular imaging warrants further evaluation in identifying the presence, extent and nature of coronary artery disease.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0192350</identifier><identifier>PMID: 29738542</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Angiography ; Arteries ; Atherosclerosis ; Biology and Life Sciences ; Blood vessels ; Cardiology ; Cardiovascular disease ; Coronary artery ; Coronary artery disease ; Coronary heart disease ; Coronary vessels ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetic retinopathy ; Diagnosis ; Diagnostic imaging ; Epidemiology ; Eye examination ; Health aspects ; Heart ; Heart diseases ; Hemorrhage ; Hypertension ; Image classification ; Males ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Methods ; Microcirculation ; Microvasculature ; Mortality ; Myocardial infarction ; Observational studies ; Photography ; Regression analysis ; Research and Analysis Methods ; Retina ; Retinal images ; Retinopathy ; Stenosis ; Studies ; Thrombolysis ; Variance analysis</subject><ispartof>PloS one, 2018-05, Vol.13 (5), p.e0192350-e0192350</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Cheng et al 2018 Cheng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c294ab5879db59b14770599cd996227923b5d67dc4a2a296b8b16d36ffef06eb3</citedby><cites>FETCH-LOGICAL-c692t-c294ab5879db59b14770599cd996227923b5d67dc4a2a296b8b16d36ffef06eb3</cites><orcidid>0000-0002-6813-0288</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940193/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940193/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29738542$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Malik, Rayaz A.</contributor><creatorcontrib>Cheng, Lisa</creatorcontrib><creatorcontrib>Barlis, Peter</creatorcontrib><creatorcontrib>Gibson, Joel</creatorcontrib><creatorcontrib>Colville, Deb</creatorcontrib><creatorcontrib>Hutchinson, Anastasia</creatorcontrib><creatorcontrib>Gleeson, Geoff</creatorcontrib><creatorcontrib>Lamoureux, Ecosse</creatorcontrib><creatorcontrib>VanGaal, William</creatorcontrib><creatorcontrib>Savige, Judy</creatorcontrib><title>Microvascular retinopathy and angiographically-demonstrated coronary artery disease: A cross-sectional, observational study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Epidemiological studies suggest retinal microvascular abnormalities predict cardiac events. This study examined microvascular features associated with coronary artery abnormalities. This was a single-centre, cross-sectional, observational study of 144 consecutive subjects undergoing coronary angiography for clinical indications. Their angiograms were deidentified and graded for disease (Leaman score, LAD stenosis ≥ 70%, number of vessels stenosed ≥ 70%), and Thrombolysis in Myocardial Infarction (TIMI) blush score. Subjects also underwent retinal photography (KOWA non-mydriatic camera, Japan), and their deidentified retinal images were graded for hypertensive microvascular retinopathy (Wong and Mitchell classification), vessel calibre using a computer-assisted method (IVAN, U Wisconsin), and diabetic retinopathy (modified Airlie House scheme) independently by a trained grader and an ophthalmologist. Retinal abnormalities were compared between subjects with high and low angiography scores using one way ANOVA, Chi squared and logistic regression analysis (StataCorp, Texas). Subjects had a mean age of 61 years (range 32-88), and included 101 males (70%). Seventeen (12%) had Leaman scores > 10.5, 46 (32%) had LAD stenosis, 13 (9%) had ≥ 3 arteries stenosed, and 20 (14%) had TIMI blush scores < 1. Twenty-six subjects (18%) had a retinal hemorrhage, and 115 (74%) a mild or moderate hypertensive retinopathy. Fifty-five (38%) had diabetes, and 24 (17%) a background (n = 20) or proliferative (n = 4) diabetic retinopathy. A retinal hemorrhage (p = 0.046), moderate microvascular retinopathy (p = 0.08) and proliferative diabetic retinopathy (p = 0.04) were all associated with a higher Leaman score. Venular calibre was increased with triple vessel disease (205.7 ± 21.6 μm, and 193.7 ± 22.3 μm in normals, p = 0.03). Diabetic retinopathy correlated with an increased TIMI blush score (p = 0.01). Retinal microvascular imaging warrants further evaluation in identifying the presence, extent and nature of coronary artery disease.</description><subject>Abnormalities</subject><subject>Angiography</subject><subject>Arteries</subject><subject>Atherosclerosis</subject><subject>Biology and Life Sciences</subject><subject>Blood vessels</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic retinopathy</subject><subject>Diagnosis</subject><subject>Diagnostic imaging</subject><subject>Epidemiology</subject><subject>Eye examination</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Hemorrhage</subject><subject>Hypertension</subject><subject>Image classification</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Microcirculation</subject><subject>Microvasculature</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Observational studies</subject><subject>Photography</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Retinal images</subject><subject>Retinopathy</subject><subject>Stenosis</subject><subject>Studies</subject><subject>Thrombolysis</subject><subject>Variance analysis</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7rr6DUQLgijYMU3apPFBGBYvAysL3l5Dbp3JkmnGpB0c_PKe2ekuU9kHKSVp-jv_k3PLsqclmpWElW-vwhA76Web0NkZKjkmNbqXnZac4IJiRO4f7U-yRyldIVSThtKH2QnmjDR1hU-zP1-cjmErkx68jHm0vevCRvarXS47A-_ShWWUm5XT0vtdYew6dKmPsrcm1yGGTkZAY29hMS5Zmey7fJ6DaEpFsrp3gPg3eVDJxq08fOapH8zucfaglT7ZJ-N6lv34-OH7-efi4vLT4nx-UWjKcV9ozCup6oZxo2quyooxVHOuDecUYwaBq9pQZnQlscScqkaV1BDatrZF1Cpylj0_6G58SGLMWxKQF1oRhBoKxOJAmCCvxCa6NUQlgnTi-iDEpYAQnfZWVAzxUjWMYltXRilO4TptpSU4JpTUoPV-9DaotTXadpAtPxGd_uncSizDVtS8gjISEHg1CsTwa7CpF2uXtPVedjYMh3uzhnKEAX3xD3p3dCO1lBCA69oAfvVeVMxrwhhvaMmAmt1BwQMldxqarHVwPjF4PTEApre_-6UcUhKLb1__n738OWVfHrErK32_SsEP-9ZJU7A6gNfNFm17m-QSif2M3GRD7GdEjDMCZs-OC3RrdDMU5C9sHQ5-</recordid><startdate>20180508</startdate><enddate>20180508</enddate><creator>Cheng, Lisa</creator><creator>Barlis, Peter</creator><creator>Gibson, Joel</creator><creator>Colville, Deb</creator><creator>Hutchinson, Anastasia</creator><creator>Gleeson, Geoff</creator><creator>Lamoureux, Ecosse</creator><creator>VanGaal, William</creator><creator>Savige, Judy</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6813-0288</orcidid></search><sort><creationdate>20180508</creationdate><title>Microvascular retinopathy and angiographically-demonstrated coronary artery disease: A cross-sectional, observational study</title><author>Cheng, Lisa ; Barlis, Peter ; Gibson, Joel ; Colville, Deb ; Hutchinson, Anastasia ; Gleeson, Geoff ; Lamoureux, Ecosse ; VanGaal, William ; Savige, Judy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-c294ab5879db59b14770599cd996227923b5d67dc4a2a296b8b16d36ffef06eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abnormalities</topic><topic>Angiography</topic><topic>Arteries</topic><topic>Atherosclerosis</topic><topic>Biology and Life Sciences</topic><topic>Blood vessels</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic retinopathy</topic><topic>Diagnosis</topic><topic>Diagnostic imaging</topic><topic>Epidemiology</topic><topic>Eye examination</topic><topic>Health aspects</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Hemorrhage</topic><topic>Hypertension</topic><topic>Image classification</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Methods</topic><topic>Microcirculation</topic><topic>Microvasculature</topic><topic>Mortality</topic><topic>Myocardial infarction</topic><topic>Observational studies</topic><topic>Photography</topic><topic>Regression analysis</topic><topic>Research and Analysis Methods</topic><topic>Retina</topic><topic>Retinal images</topic><topic>Retinopathy</topic><topic>Stenosis</topic><topic>Studies</topic><topic>Thrombolysis</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Lisa</creatorcontrib><creatorcontrib>Barlis, Peter</creatorcontrib><creatorcontrib>Gibson, Joel</creatorcontrib><creatorcontrib>Colville, Deb</creatorcontrib><creatorcontrib>Hutchinson, Anastasia</creatorcontrib><creatorcontrib>Gleeson, Geoff</creatorcontrib><creatorcontrib>Lamoureux, Ecosse</creatorcontrib><creatorcontrib>VanGaal, William</creatorcontrib><creatorcontrib>Savige, Judy</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Lisa</au><au>Barlis, Peter</au><au>Gibson, Joel</au><au>Colville, Deb</au><au>Hutchinson, Anastasia</au><au>Gleeson, Geoff</au><au>Lamoureux, Ecosse</au><au>VanGaal, William</au><au>Savige, Judy</au><au>Malik, Rayaz A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microvascular retinopathy and angiographically-demonstrated coronary artery disease: A cross-sectional, observational study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-05-08</date><risdate>2018</risdate><volume>13</volume><issue>5</issue><spage>e0192350</spage><epage>e0192350</epage><pages>e0192350-e0192350</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Epidemiological studies suggest retinal microvascular abnormalities predict cardiac events. This study examined microvascular features associated with coronary artery abnormalities. This was a single-centre, cross-sectional, observational study of 144 consecutive subjects undergoing coronary angiography for clinical indications. Their angiograms were deidentified and graded for disease (Leaman score, LAD stenosis ≥ 70%, number of vessels stenosed ≥ 70%), and Thrombolysis in Myocardial Infarction (TIMI) blush score. Subjects also underwent retinal photography (KOWA non-mydriatic camera, Japan), and their deidentified retinal images were graded for hypertensive microvascular retinopathy (Wong and Mitchell classification), vessel calibre using a computer-assisted method (IVAN, U Wisconsin), and diabetic retinopathy (modified Airlie House scheme) independently by a trained grader and an ophthalmologist. Retinal abnormalities were compared between subjects with high and low angiography scores using one way ANOVA, Chi squared and logistic regression analysis (StataCorp, Texas). Subjects had a mean age of 61 years (range 32-88), and included 101 males (70%). Seventeen (12%) had Leaman scores > 10.5, 46 (32%) had LAD stenosis, 13 (9%) had ≥ 3 arteries stenosed, and 20 (14%) had TIMI blush scores < 1. Twenty-six subjects (18%) had a retinal hemorrhage, and 115 (74%) a mild or moderate hypertensive retinopathy. Fifty-five (38%) had diabetes, and 24 (17%) a background (n = 20) or proliferative (n = 4) diabetic retinopathy. A retinal hemorrhage (p = 0.046), moderate microvascular retinopathy (p = 0.08) and proliferative diabetic retinopathy (p = 0.04) were all associated with a higher Leaman score. Venular calibre was increased with triple vessel disease (205.7 ± 21.6 μm, and 193.7 ± 22.3 μm in normals, p = 0.03). Diabetic retinopathy correlated with an increased TIMI blush score (p = 0.01). Retinal microvascular imaging warrants further evaluation in identifying the presence, extent and nature of coronary artery disease.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29738542</pmid><doi>10.1371/journal.pone.0192350</doi><tpages>e0192350</tpages><orcidid>https://orcid.org/0000-0002-6813-0288</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2018-05, Vol.13 (5), p.e0192350-e0192350 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2036430086 |
| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Abnormalities Angiography Arteries Atherosclerosis Biology and Life Sciences Blood vessels Cardiology Cardiovascular disease Coronary artery Coronary artery disease Coronary heart disease Coronary vessels Development and progression Diabetes Diabetes mellitus Diabetic retinopathy Diagnosis Diagnostic imaging Epidemiology Eye examination Health aspects Heart Heart diseases Hemorrhage Hypertension Image classification Males Medical imaging Medicine Medicine and Health Sciences Methods Microcirculation Microvasculature Mortality Myocardial infarction Observational studies Photography Regression analysis Research and Analysis Methods Retina Retinal images Retinopathy Stenosis Studies Thrombolysis Variance analysis |
| title | Microvascular retinopathy and angiographically-demonstrated coronary artery disease: A cross-sectional, observational study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T05%3A40%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microvascular%20retinopathy%20and%20angiographically-demonstrated%20coronary%20artery%20disease:%20A%20cross-sectional,%20observational%20study&rft.jtitle=PloS%20one&rft.au=Cheng,%20Lisa&rft.date=2018-05-08&rft.volume=13&rft.issue=5&rft.spage=e0192350&rft.epage=e0192350&rft.pages=e0192350-e0192350&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0192350&rft_dat=%3Cgale_plos_%3EA537798617%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2036430086&rft_id=info:pmid/29738542&rft_galeid=A537798617&rft_doaj_id=oai_doaj_org_article_47091b8762e54dbb96770f4ca96b3635&rfr_iscdi=true |