Consumption of antibiotics in Chinese public general tertiary hospitals (2011-2014): Trends, pattern changes and regional differences
China has a high rate of antibiotic use. The Chinese Ministry of Health (MOH) established the Center for Antibacterial Surveillance (CAS) to monitor the use of antibacterial agents in hospitals in 2005. The purpose of this study was to identify trends, pattern changes and regional differences in ant...
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| description | China has a high rate of antibiotic use. The Chinese Ministry of Health (MOH) established the Center for Antibacterial Surveillance (CAS) to monitor the use of antibacterial agents in hospitals in 2005. The purpose of this study was to identify trends, pattern changes and regional differences in antibiotic consumption in 151 public general tertiary hospitals across China from 2011-2014.
Valid data for antibiotic use were collected quarterly, and the antibiotic consumption data were expressed as the defined daily dose (DDD) per 100 inpatient days (ID). We compared the patterns of antibiotic use in different classes and geographical clusters.
Total antibiotic use significantly decreased (P = 0.018) from 75.86 DDD/100 ID in 2011 to 47.03 DDD/100 ID in 2014. The total consumption of flomoxef sodium and cefminox increased from 1.31 DDD/100 BD in 2011 to 8.6 DDD/100 BD in 2014. Cephalosporins were the most frequently used antibiotics in all regions. Third-generation cephalosporins accounted for more than 45% of the cephalosporins used. Carbapenem use substantially increased (P = 0.043). Penicillin combinations with inhibitors accounted for 50% of the penicillin used, and prescribed meropenem accounted for most of the carbapenems used in all regions in 2014. The subclasses in each antibiotic group were used differently between the seven regions, and the total hospital antibiotic use in 2014 differed significantly by region (P = 0.014).
Although the volume and intensity of total antibiotic use decreased, the antibiotic use patterns were not optimal, and broad-spectrum antibiotics were still the main classes. The aggregate data obtained during the study period reveal similar antibiotic consumption patterns in different regions. These findings provide useful information for improving the rational use of antibiotics. More detailed data on antibiotics linked to inpatient diseases need to be collected in future studies. |
| doi_str_mv | 10.1371/journal.pone.0196668 |
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Valid data for antibiotic use were collected quarterly, and the antibiotic consumption data were expressed as the defined daily dose (DDD) per 100 inpatient days (ID). We compared the patterns of antibiotic use in different classes and geographical clusters.
Total antibiotic use significantly decreased (P = 0.018) from 75.86 DDD/100 ID in 2011 to 47.03 DDD/100 ID in 2014. The total consumption of flomoxef sodium and cefminox increased from 1.31 DDD/100 BD in 2011 to 8.6 DDD/100 BD in 2014. Cephalosporins were the most frequently used antibiotics in all regions. Third-generation cephalosporins accounted for more than 45% of the cephalosporins used. Carbapenem use substantially increased (P = 0.043). Penicillin combinations with inhibitors accounted for 50% of the penicillin used, and prescribed meropenem accounted for most of the carbapenems used in all regions in 2014. The subclasses in each antibiotic group were used differently between the seven regions, and the total hospital antibiotic use in 2014 differed significantly by region (P = 0.014).
Although the volume and intensity of total antibiotic use decreased, the antibiotic use patterns were not optimal, and broad-spectrum antibiotics were still the main classes. The aggregate data obtained during the study period reveal similar antibiotic consumption patterns in different regions. These findings provide useful information for improving the rational use of antibiotics. More detailed data on antibiotics linked to inpatient diseases need to be collected in future studies.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0196668</identifier><identifier>PMID: 29723230</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Antibacterial agents ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial agents ; Biology and Life Sciences ; Carbapenems ; Cefminox ; Cephalosporins ; China ; Consumption ; Dosage ; Drug resistance ; Flomoxef ; Global health ; Health care ; Health economics ; Hospitals ; Laboratories ; Management ; Medicine and Health Sciences ; Meropenem ; Patients ; Penicillin ; People and Places ; Prescription drugs ; Public health ; Regional differences ; Sodium ; Staphylococcus infections ; Studies ; Surveillance ; Trends</subject><ispartof>PloS one, 2018-05, Vol.13 (5), p.e0196668-e0196668</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Qu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Qu et al 2018 Qu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-1f8e3e3c49edba0ad8a57a3a771599f707ddd630c5e460e1af1275d128b9a6563</citedby><cites>FETCH-LOGICAL-c593t-1f8e3e3c49edba0ad8a57a3a771599f707ddd630c5e460e1af1275d128b9a6563</cites><orcidid>0000-0001-8046-0936</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933762/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933762/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29723230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>De Socio, Giuseppe Vittorio</contributor><creatorcontrib>Qu, Xiaoyuan</creatorcontrib><creatorcontrib>Yin, Chang</creatorcontrib><creatorcontrib>Sun, Xihong</creatorcontrib><creatorcontrib>Huang, Shusheng</creatorcontrib><creatorcontrib>Li, Chaofan</creatorcontrib><creatorcontrib>Dong, Panpan</creatorcontrib><creatorcontrib>Lu, Xiufang</creatorcontrib><creatorcontrib>Zhang, Zhuo</creatorcontrib><creatorcontrib>Yin, Aitian</creatorcontrib><title>Consumption of antibiotics in Chinese public general tertiary hospitals (2011-2014): Trends, pattern changes and regional differences</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>China has a high rate of antibiotic use. The Chinese Ministry of Health (MOH) established the Center for Antibacterial Surveillance (CAS) to monitor the use of antibacterial agents in hospitals in 2005. The purpose of this study was to identify trends, pattern changes and regional differences in antibiotic consumption in 151 public general tertiary hospitals across China from 2011-2014.
Valid data for antibiotic use were collected quarterly, and the antibiotic consumption data were expressed as the defined daily dose (DDD) per 100 inpatient days (ID). We compared the patterns of antibiotic use in different classes and geographical clusters.
Total antibiotic use significantly decreased (P = 0.018) from 75.86 DDD/100 ID in 2011 to 47.03 DDD/100 ID in 2014. The total consumption of flomoxef sodium and cefminox increased from 1.31 DDD/100 BD in 2011 to 8.6 DDD/100 BD in 2014. Cephalosporins were the most frequently used antibiotics in all regions. Third-generation cephalosporins accounted for more than 45% of the cephalosporins used. Carbapenem use substantially increased (P = 0.043). Penicillin combinations with inhibitors accounted for 50% of the penicillin used, and prescribed meropenem accounted for most of the carbapenems used in all regions in 2014. The subclasses in each antibiotic group were used differently between the seven regions, and the total hospital antibiotic use in 2014 differed significantly by region (P = 0.014).
Although the volume and intensity of total antibiotic use decreased, the antibiotic use patterns were not optimal, and broad-spectrum antibiotics were still the main classes. The aggregate data obtained during the study period reveal similar antibiotic consumption patterns in different regions. These findings provide useful information for improving the rational use of antibiotics. More detailed data on antibiotics linked to inpatient diseases need to be collected in future studies.</description><subject>Analysis</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Biology and Life Sciences</subject><subject>Carbapenems</subject><subject>Cefminox</subject><subject>Cephalosporins</subject><subject>China</subject><subject>Consumption</subject><subject>Dosage</subject><subject>Drug resistance</subject><subject>Flomoxef</subject><subject>Global health</subject><subject>Health care</subject><subject>Health economics</subject><subject>Hospitals</subject><subject>Laboratories</subject><subject>Management</subject><subject>Medicine and Health Sciences</subject><subject>Meropenem</subject><subject>Patients</subject><subject>Penicillin</subject><subject>People and Places</subject><subject>Prescription drugs</subject><subject>Public health</subject><subject>Regional differences</subject><subject>Sodium</subject><subject>Staphylococcus 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of antibiotics in Chinese public general tertiary hospitals (2011-2014): Trends, pattern changes and regional differences</title><author>Qu, Xiaoyuan ; Yin, Chang ; Sun, Xihong ; Huang, Shusheng ; Li, Chaofan ; Dong, Panpan ; Lu, Xiufang ; Zhang, Zhuo ; Yin, Aitian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-1f8e3e3c49edba0ad8a57a3a771599f707ddd630c5e460e1af1275d128b9a6563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Biology and Life Sciences</topic><topic>Carbapenems</topic><topic>Cefminox</topic><topic>Cephalosporins</topic><topic>China</topic><topic>Consumption</topic><topic>Dosage</topic><topic>Drug resistance</topic><topic>Flomoxef</topic><topic>Global health</topic><topic>Health care</topic><topic>Health economics</topic><topic>Hospitals</topic><topic>Laboratories</topic><topic>Management</topic><topic>Medicine and Health Sciences</topic><topic>Meropenem</topic><topic>Patients</topic><topic>Penicillin</topic><topic>People and Places</topic><topic>Prescription drugs</topic><topic>Public health</topic><topic>Regional differences</topic><topic>Sodium</topic><topic>Staphylococcus infections</topic><topic>Studies</topic><topic>Surveillance</topic><topic>Trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qu, Xiaoyuan</creatorcontrib><creatorcontrib>Yin, Chang</creatorcontrib><creatorcontrib>Sun, Xihong</creatorcontrib><creatorcontrib>Huang, Shusheng</creatorcontrib><creatorcontrib>Li, Chaofan</creatorcontrib><creatorcontrib>Dong, Panpan</creatorcontrib><creatorcontrib>Lu, Xiufang</creatorcontrib><creatorcontrib>Zhang, Zhuo</creatorcontrib><creatorcontrib>Yin, 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and regional differences</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2018-05-03</date><risdate>2018</risdate><volume>13</volume><issue>5</issue><spage>e0196668</spage><epage>e0196668</epage><pages>e0196668-e0196668</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>China has a high rate of antibiotic use. The Chinese Ministry of Health (MOH) established the Center for Antibacterial Surveillance (CAS) to monitor the use of antibacterial agents in hospitals in 2005. The purpose of this study was to identify trends, pattern changes and regional differences in antibiotic consumption in 151 public general tertiary hospitals across China from 2011-2014.
Valid data for antibiotic use were collected quarterly, and the antibiotic consumption data were expressed as the defined daily dose (DDD) per 100 inpatient days (ID). We compared the patterns of antibiotic use in different classes and geographical clusters.
Total antibiotic use significantly decreased (P = 0.018) from 75.86 DDD/100 ID in 2011 to 47.03 DDD/100 ID in 2014. The total consumption of flomoxef sodium and cefminox increased from 1.31 DDD/100 BD in 2011 to 8.6 DDD/100 BD in 2014. Cephalosporins were the most frequently used antibiotics in all regions. Third-generation cephalosporins accounted for more than 45% of the cephalosporins used. Carbapenem use substantially increased (P = 0.043). Penicillin combinations with inhibitors accounted for 50% of the penicillin used, and prescribed meropenem accounted for most of the carbapenems used in all regions in 2014. The subclasses in each antibiotic group were used differently between the seven regions, and the total hospital antibiotic use in 2014 differed significantly by region (P = 0.014).
Although the volume and intensity of total antibiotic use decreased, the antibiotic use patterns were not optimal, and broad-spectrum antibiotics were still the main classes. The aggregate data obtained during the study period reveal similar antibiotic consumption patterns in different regions. These findings provide useful information for improving the rational use of antibiotics. More detailed data on antibiotics linked to inpatient diseases need to be collected in future studies.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29723230</pmid><doi>10.1371/journal.pone.0196668</doi><orcidid>https://orcid.org/0000-0001-8046-0936</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Full-Text Journals in Chemistry (Open access); Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Analysis Antibacterial agents Antibiotics Antiinfectives and antibacterials Antimicrobial agents Biology and Life Sciences Carbapenems Cefminox Cephalosporins China Consumption Dosage Drug resistance Flomoxef Global health Health care Health economics Hospitals Laboratories Management Medicine and Health Sciences Meropenem Patients Penicillin People and Places Prescription drugs Public health Regional differences Sodium Staphylococcus infections Studies Surveillance Trends |
| title | Consumption of antibiotics in Chinese public general tertiary hospitals (2011-2014): Trends, pattern changes and regional differences |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T15%3A15%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Consumption%20of%20antibiotics%20in%20Chinese%20public%20general%20tertiary%20hospitals%20(2011-2014):%20Trends,%20pattern%20changes%20and%20regional%20differences&rft.jtitle=PloS%20one&rft.au=Qu,%20Xiaoyuan&rft.date=2018-05-03&rft.volume=13&rft.issue=5&rft.spage=e0196668&rft.epage=e0196668&rft.pages=e0196668-e0196668&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0196668&rft_dat=%3Cgale_plos_%3EA537218262%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2034348320&rft_id=info:pmid/29723230&rft_galeid=A537218262&rft_doaj_id=oai_doaj_org_article_c639c9125762439e89f3b89fedb832db&rfr_iscdi=true |