Sarcopenia and myosteatosis are accompanied by distinct biological profiles in patients with pancreatic and periampullary adenocarcinomas

Pancreatic and periampullary adenocarcinomas are associated with abnormal body composition visible on CT scans, including low muscle mass (sarcopenia) and low muscle radiodensity due to fat infiltration in muscle (myosteatosis). The biological and clinical correlates to these features are poorly und...

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Veröffentlicht in:	PloS one 2018-05, Vol.13 (5), p.e0196235-e0196235
Hauptverfasser:	Stretch, Cynthia, Aubin, Jean-Michel, Mickiewicz, Beata, Leugner, Derek, Al-Manasra, Tariq, Tobola, Elizabeth, Salazar, Santiago, Sutherland, Francis R, Ball, Chad G, Dixon, Elijah, Vogel, Hans J, Damaraju, Sambasivario, Baracos, Vickie E, Bathe, Oliver F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - complications Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adipose tissue Adipose Tissue - pathology Aged Ampulla of Vater Bioinformatics Biological markers Biology and Life Sciences Body Composition Cancer therapies Carbohydrate metabolism Carbohydrates Care and treatment Catabolism Computed tomography Diabetes Diagnosis DNA microarrays Duodenal Neoplasms - complications Duodenal Neoplasms - genetics Duodenal Neoplasms - metabolism Duodenal Neoplasms - pathology Female Funding Gas chromatography Gene expression Gene Expression Profiling Hepatitis Humans Identification and classification Infiltration Insulin resistance Laboratories Liver cancer Magnetic resonance spectroscopy Male Mass spectrometry Mass spectroscopy Medical imaging Medical prognosis Medicine and Health Sciences Metabolism Metabolites Metabolomics Metastases Middle Aged Muscles Muscles - pathology Musculoskeletal system NMR spectroscopy Obesity Oncology Oxidative phosphorylation Pancreatic cancer Pancreatic Neoplasms - complications Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreaticoduodenectomy Patients Phenotypes Phosphorylation Physical Sciences Physiological aspects Research and Analysis Methods Sarcopenia Sarcopenia - complications Spectroscopy Subgroups Surgery Survival
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