Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflammation and thrombosis. Plasma haptoglobin and hemopexin scavenge free hemoglobin and heme, respectively, but can be depleted in hemolytic states. Haptoglobin and hemopexin supplementation protect tiss...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0196455-e0196455
Hauptverfasser:	Belcher, John D, Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Nguyen, Hao, Nguyen, Phong, Killeen, Trevor, Miescher, Sylvia M, Brinkman, Nathan, Nath, Karl A, Steer, Clifford J, Vercellotti, Gregory M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - analysis Anemia, Sickle Cell - pathology Anemia, Sickle Cell - prevention & control Animal models Animals Biology Biology and Life Sciences Blood Blood cells Carbon monoxide Carbon Monoxide - pharmacology Cytokines - analysis Disease Models, Animal Endothelial cells Erythrocytes Female Gene Expression - drug effects Glycosylated hemoglobin Haptoglobin Haptoglobins - pharmacology Haptoglobins - therapeutic use Hematology Heme Heme oxygenase (decyclizing) Heme Oxygenase-1 - metabolism Hemoglobin Hemopexin Hemopexin - pharmacology Hemopexin - therapeutic use Hypoxia Inflammation Inflammation - prevention & control Intercellular Adhesion Molecule-1 Kidneys Lipopolysaccharides Liver Male Medicine Medicine and Health Sciences Metalloporphyrins - pharmacology Mice Microsomes, Liver - metabolism Occlusion Oncology Organs Oxidative stress Oxygenase P-selectin Protoporphyrin Protoporphyrins - pharmacology R&D Research & development Research and Analysis Methods Rodents Sickle cell disease Skin Skin - metabolism Skin - pathology Supplements Thromboembolism Thrombosis Tin Tin protoporphyrin Transcription Factor RelA - metabolism Vascular Cell Adhesion Molecule-1 - metabolism Von Willebrand factor
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