Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells

We previously identified ovostatin 2 (OVOS2) as a new candidate gene for cutaneous malignant melanoma (CMM) in a Chinese population. In this study, we aimed to investigate the exact role of OVOS2 in cell proliferation, invasion, and tumorigenesis of melanoma A375 cells. The downregulation of OVOS2 e...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0195610
Hauptverfasser:	Huang, Ying-Xue, Song, Hao, Tao, Yue, Shao, Xue-Bao, Zeng, Xue-Si, Xu, Xiu-Lian, Qi, Jin-Liang, Sun, Jian-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein alpha-Macroglobulins - antagonists & inhibitors alpha-Macroglobulins - genetics alpha-Macroglobulins - metabolism Animals Apoptosis Apoptosis - physiology Biology and Life Sciences Carcinogenesis - metabolism Carcinogenesis - pathology Cell adhesion & migration Cell cycle Cell Cycle - physiology Cell growth Cell Line, Tumor Cell migration Cell Movement - physiology Cell proliferation Cell Proliferation - physiology Chinese (Asian people) Dermatology E-cadherin Experiments Expression vectors Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Kinases MAP kinase Medicine and Health Sciences Melanoma Melanoma - metabolism Melanoma - pathology Melanoma, Cutaneous Malignant Mesenchyme Metastasis Mice, Inbred BALB C Mice, Nude N-Cadherin Neoplasm Invasiveness - pathology Neoplasm Invasiveness - physiopathology Neoplasm Transplantation Pathogenesis Phase transitions Phenotypes Population studies Proteins Random Allocation Research and Analysis Methods RNA, Messenger - metabolism Signal transduction Skin cancer Skin Neoplasms - metabolism Skin Neoplasms - pathology Transplantation Tumorigenesis Tumorigenicity Tumors β-Catenin
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