Understanding the impact of the cofactor swapping of isocitrate dehydrogenase over the growth phenotype of Escherichia coli on acetate by using constraint-based modeling

It has been proposed that NADP+-specificity of isocitrate dehydrogenase (ICDH) evolved as an adaptation of microorganisms to grow on acetate as the sole source of carbon and energy. In Escherichia coli, changing the cofactor specificity of ICDH from NADP+ to NAD+ (cofactor swapping) decreases the gr...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0196182-e0196182
Hauptverfasser:	Armingol, Erick, Tobar, Eduardo, Cabrera, Ricardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acetic Acid - metabolism Adenosine Triphosphate - metabolism ATP Bacteria Bacterial growth Bifurcations Biological evolution Biology and Life Sciences Biomass Biosynthesis Carbon Computer simulation Constraint modelling Dehydrogenase Dehydrogenases E coli Earth Sciences Ecology and Environmental Sciences Energy Energy Metabolism Enzymes Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - growth & development Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fluxes Gene Deletion Genetic aspects Genomes Genotype & phenotype Growth Growth rate Hypotheses Isocitrate dehydrogenase Isocitrate Dehydrogenase - metabolism Isocitrate lyase Malic enzyme Medicine and Health Sciences Metabolic flux Metabolism Metabolites Microorganisms Modelling NAD NAD - metabolism NADP NADP - metabolism NADP Transhydrogenases - genetics Oxidoreductases Pentose Pentose phosphate pathway Phenotype Phenotypes Phosphorylation Physical Sciences Physiological aspects
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