Solo, a RhoA-targeting guanine nucleotide exchange factor, is critical for hemidesmosome formation and acinar development in epithelial cells

Cell-substrate adhesions are essential for various physiological processes, including embryonic development and maintenance of organ functions. Hemidesmosomes (HDs) are multiprotein complexes that attach epithelial cells to the basement membrane. Formation and remodeling of HDs are dependent on the...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0195124-e0195124
Hauptverfasser:	Fujiwara, Sachiko, Matsui, Tsubasa S, Ohashi, Kazumasa, Deguchi, Shinji, Mizuno, Kensaku
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - metabolism Actin Amino acids Analysis Animals Apoptosis Bioengineering Biology Biology and life sciences Cancer Cell adhesion & migration Cell growth Cell Line Coprecipitation Cytoskeleton Embryogenesis Embryonic development Embryonic growth stage Engineering schools Enzyme inhibitors Epidermal growth factor Epithelial cells Epithelial Cells - metabolism Filaments Gene Expression Gene Knockdown Techniques Guanine Guanine nucleotide exchange factor Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Hemidesmosomes Hemidesmosomes - metabolism Humans Immunoglobulins Integrin beta4 - chemistry Integrin beta4 - metabolism Integrins Intermediate filaments Keratin Keratin-18 - genetics Keratin-18 - metabolism Life sciences Mammary gland Medicine and Health Sciences Morphogenesis Muscle proteins Physiological aspects Plasmids Precipitates Protein Binding Protein Interaction Domains and Motifs Proteins Research and Analysis Methods Rho-associated kinase RhoA protein Rocks Signal Transduction Signaling Substrates Traction force
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