Exogenous pentraxin-3 inhibits the reactive oxygen species-mitochondrial and apoptosis pathway in acute kidney injury

Pentraxin-3 (PTX3) is a long-form member of the pentraxin family of proteins that has been studied in inflammatory diseases and in various organs. We found that PTX3 protects kidney cells during ischemia and proinflammatory acute kidney injury. The aim of this study was to develop an in vitro experi...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0195758-e0195758
Hauptverfasser:	Lee, Hyung Ho, Kim, Sook Young, Na, Joon Chae, Yoon, Young Eun, Han, Woong Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute kidney failure Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Analysis Apoptosis Apoptosis - drug effects Biology and Life Sciences C-Reactive Protein - pharmacology Calcimycin Calcium Calcium (intracellular) Calcium content Calcium ionophores Calpain Caspase Caspase-3 Cell Line Cell Survival - drug effects Clear cell-type renal cell carcinoma Humans Hypoxia Hypoxia - drug therapy Hypoxia - metabolism Inflammation Inflammatory diseases Injuries Injury analysis Ischemia Ischemia - drug therapy Ischemia - metabolism Kidney diseases Kidneys Matrix Metalloproteinases Medicine Medicine and Health Sciences Membrane potential Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial membrane Organs Oxygen Pentraxins Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase 1 Protective Agents - pharmacology Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Research and Analysis Methods Rodents Serum Amyloid P-Component - pharmacology Tumor necrosis factor-TNF Urology
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