The somatostatin receptor 2 antagonist 64Cu-NODAGA-JR11 outperforms 64Cu-DOTA-TATE in a mouse xenograft model

Copper-64 is an attractive radionuclide for PET imaging and is frequently used in clinical applications. The aim of this study was to perform a side-by-side comparison of the in vitro and in vivo performance of 64Cu-NODAGA-JR11 (NODAGA = 1,4,7-triazacyclononane,1-glutaric acid,4,7-acetic acid, JR11...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0195802
Hauptverfasser:	Rylova, Svetlana N, Stoykow, Christian, Del Pozzo, Luigi, Abiraj, Keelara, Tamma, Maria Luisa, Kiefer, Yvonne, Fani, Melpomeni, Maecke, Helmut R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Acetates - pharmacokinetics Acetic acid Acids Amino acids Animals Antagonists Binding sites Biology and Life Sciences Blood Cell culture Chromatography Coinjection Copper Copper Radioisotopes - chemistry Disease Models, Animal HEK293 Cells Heterocyclic Compounds, 1-Ring - chemistry Heterocyclic Compounds, 1-Ring - pharmacokinetics Heterografts Humans In vivo methods and tests Internalization Kidneys Liver Lungs Mass spectrometry Medicine and Health Sciences Mice Molecular Imaging Molecular Structure Neoplasms - diagnostic imaging Neoplasms - metabolism Nuclear medicine Peptides Pharmacokinetics Pharmacology Physical Sciences Positron emission Positron emission tomography Positron-Emission Tomography - methods Radioisotopes Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Receptors, Somatostatin - antagonists & inhibitors Research and Analysis Methods Scientific imaging Somatostatin Therapeutic applications Tissue Distribution Tomography Tumors Washout Xenografts Xenotransplantation
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