Humoral immunity to memory antigens and pathogens is maintained in patients with chronic kidney disease

Patients with chronic kidney disease (CKD) have an increased risk of infection and poorer responses to vaccination. This suggests that CKD patients have an impaired responsiveness to all antigens, even those first encountered before CKD onset. To examine this we evaluated antibody responses against...

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Veröffentlicht in:	PloS one 2018-04, Vol.13 (4), p.e0195730-e0195730
Hauptverfasser:	Wall, Nadezhda A, Dominguez-Medina, C Coral, Faustini, Sian E, Cook, Charlotte N, McClean, Andrew, Jesky, Mark D, Perez-Toledo, Marisol, Morgan, Matthew D, Richter, Alexandra G, Ferro, Charles J, Cockwell, Paul, Moss, Paul A, Henderson, Ian R, Harper, Lorraine, Cunningham, Adam F
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Antibodies, Bacterial - immunology Antigens Antigens - immunology Bactericidal activity Biology and Life Sciences Biomarkers Care and treatment Children Chronic infection Chronic kidney failure Cytomegalovirus Diphtheria Female Health aspects Health care Health risks Hospitals Host-Pathogen Interactions - immunology Humans Humoral immunity Immunity Immunity (Disease) Immunity, Humoral Immunodeficiency Immunoglobulin G Immunoglobulin G - immunology Immunologic Memory Immunological memory Infections Infections - etiology Kidney diseases Kidneys Lipopolysaccharides Male Medicine and Health Sciences Middle Aged Mitogens Mortality Nephrology Pathogens Patients Peritoneal dialysis Population Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - immunology Research and Analysis Methods Risk factors Salmonella Serum bactericidal activity Tetanus Toxoids Vaccines
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