SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data

RNA-protein binding is critical to gene regulation, controlling fundamental processes including splicing, translation, localization and stability, and aberrant RNA-protein interactions are known to play a role in a wide variety of diseases. However, molecular understanding of RNA-protein interaction...

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Veröffentlicht in:	PLoS computational biology 2018-03, Vol.14 (3), p.e1006078-e1006078
Hauptverfasser:	Dotu, Ivan, Adamson, Scott I, Coleman, Benjamin, Fournier, Cyril, Ricart-Altimiras, Emma, Eyras, Eduardo, Chuang, Jeffrey H
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Artificial intelligence Authorship Binding Binding Sites Bioinformatics Biology and life sciences Cluster Analysis Clustering Clustering algorithms Control stability Crosslinking Data processing Double stranded RNA Funding Gene expression Gene regulation Gene sequencing Genomes High-Throughput Nucleotide Sequencing - methods Hospitals Immunoprecipitation Informatics Laboratories Localization Medical research Medicine Next-generation sequencing Nucleic Acid Conformation Nucleotide Motifs Nucleotide sequence Observations Physical Sciences Protein Binding Protein interaction Proteins Research and Analysis Methods Ribonucleic acid RNA RNA - genetics RNA folding RNA Recognition Motif Proteins - genetics RNA Recognition Motif Proteins - physiology RNA structure RNA-binding protein RNA-binding proteins RNA-Binding Proteins - metabolism RNA-protein interactions Roles Sequence alignment Sequence Analysis, RNA - methods Sequence motif analysis Software Splicing Splicing factors
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