The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti
The Notch signaling pathway is a highly evolutionarily-conserved cell-cell signaling pathway that regulates many events during development. It plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embry...
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Veröffentlicht in: | PLoS neglected tropical diseases 2018-03, Vol.12 (3), p.e0006307-e0006307 |
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description | The Notch signaling pathway is a highly evolutionarily-conserved cell-cell signaling pathway that regulates many events during development. It plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embryonic and adult development. However, functions of Notch signaling in Aedes aegypti, the major mosquito vector for dengue, are largely unknown. In this study, we identified a unique feature of A. aegypti Notch (AaNotch) in the control of the sterile-like phenotype in female mosquitoes. Silencing AaNotch with a reverse genetic approach significantly reduced the fecundity and fertility of the mosquito. Silencing AaNotch also resulted in the prevention of micropyle formation, which led to impaired fertilization. In addition, JNK phosphorylation (a signaling molecule in the non-canonical Notch signaling pathway) was inhibited in the absence of AaNotch. Furthermore, treatment with a JNK inhibitor in the mosquito resulted in impaired fecundity and fertility. Taken together, our results demonstrate that non-canonical Notch signaling is essential for controlling fertility in the A. aegypti mosquito. |
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It plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embryonic and adult development. However, functions of Notch signaling in Aedes aegypti, the major mosquito vector for dengue, are largely unknown. In this study, we identified a unique feature of A. aegypti Notch (AaNotch) in the control of the sterile-like phenotype in female mosquitoes. Silencing AaNotch with a reverse genetic approach significantly reduced the fecundity and fertility of the mosquito. Silencing AaNotch also resulted in the prevention of micropyle formation, which led to impaired fertilization. In addition, JNK phosphorylation (a signaling molecule in the non-canonical Notch signaling pathway) was inhibited in the absence of AaNotch. Furthermore, treatment with a JNK inhibitor in the mosquito resulted in impaired fecundity and fertility. Taken together, our results demonstrate that non-canonical Notch signaling is essential for controlling fertility in the A. aegypti mosquito.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0006307</identifier><identifier>PMID: 29505577</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adenosine triphosphatase ; Aedes aegypti ; Amino acids ; Aquatic insects ; Biological fertilization ; Biology and Life Sciences ; Cell proliferation ; Cellular signal transduction ; Control ; Culicidae ; Dengue ; Dengue fever ; Drosophila ; Embryogenesis ; Fecundity ; Fertility ; Fertilization ; Genetic aspects ; Human diseases ; Insecticides ; Insects ; JNK protein ; Medicine and Health Sciences ; Mosquitoes ; Notch protein ; Parasitology ; Phenotypes ; Phosphorylation ; Physiological aspects ; Product development ; Proliferation ; Research and Analysis Methods ; Signal transduction ; Signaling ; Stem cells ; Tropical diseases ; Vaccines ; Vector-borne diseases ; Wolbachia ; Yellow fever mosquito</subject><ispartof>PLoS neglected tropical diseases, 2018-03, Vol.12 (3), p.e0006307-e0006307</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: . PLoS Negl Trop Dis 12(3): e0006307. https://doi.org/10.1371/journal.pntd.0006307</rights><rights>2018 Chang et al 2018 Chang et al</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: . PLoS Negl Trop Dis 12(3): e0006307. https://doi.org/10.1371/journal.pntd.0006307</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c690t-9629b8ef768ccbf96530119f613ebd53b837555655820ec329977502143354003</citedby><cites>FETCH-LOGICAL-c690t-9629b8ef768ccbf96530119f613ebd53b837555655820ec329977502143354003</cites><orcidid>0000-0002-7749-7807</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854436/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854436/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29505577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bartholomay, Lyric C.</contributor><creatorcontrib>Chang, Chia-Hao</creatorcontrib><creatorcontrib>Liu, Yu-Ting</creatorcontrib><creatorcontrib>Weng, Shih-Che</creatorcontrib><creatorcontrib>Chen, I-Yi</creatorcontrib><creatorcontrib>Tsao, Po-Nien</creatorcontrib><creatorcontrib>Shiao, Shin-Hong</creatorcontrib><title>The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>The Notch signaling pathway is a highly evolutionarily-conserved cell-cell signaling pathway that regulates many events during development. It plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embryonic and adult development. However, functions of Notch signaling in Aedes aegypti, the major mosquito vector for dengue, are largely unknown. In this study, we identified a unique feature of A. aegypti Notch (AaNotch) in the control of the sterile-like phenotype in female mosquitoes. Silencing AaNotch with a reverse genetic approach significantly reduced the fecundity and fertility of the mosquito. Silencing AaNotch also resulted in the prevention of micropyle formation, which led to impaired fertilization. In addition, JNK phosphorylation (a signaling molecule in the non-canonical Notch signaling pathway) was inhibited in the absence of AaNotch. Furthermore, treatment with a JNK inhibitor in the mosquito resulted in impaired fecundity and fertility. Taken together, our results demonstrate that non-canonical Notch signaling is essential for controlling fertility in the A. aegypti mosquito.</description><subject>Adenosine triphosphatase</subject><subject>Aedes aegypti</subject><subject>Amino acids</subject><subject>Aquatic insects</subject><subject>Biological fertilization</subject><subject>Biology and Life Sciences</subject><subject>Cell proliferation</subject><subject>Cellular signal transduction</subject><subject>Control</subject><subject>Culicidae</subject><subject>Dengue</subject><subject>Dengue fever</subject><subject>Drosophila</subject><subject>Embryogenesis</subject><subject>Fecundity</subject><subject>Fertility</subject><subject>Fertilization</subject><subject>Genetic aspects</subject><subject>Human diseases</subject><subject>Insecticides</subject><subject>Insects</subject><subject>JNK protein</subject><subject>Medicine and Health Sciences</subject><subject>Mosquitoes</subject><subject>Notch protein</subject><subject>Parasitology</subject><subject>Phenotypes</subject><subject>Phosphorylation</subject><subject>Physiological aspects</subject><subject>Product development</subject><subject>Proliferation</subject><subject>Research and Analysis Methods</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Stem cells</subject><subject>Tropical diseases</subject><subject>Vaccines</subject><subject>Vector-borne diseases</subject><subject>Wolbachia</subject><subject>Yellow fever 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signaling is essential for the control of fertility in Aedes aegypti</title><author>Chang, Chia-Hao ; Liu, Yu-Ting ; Weng, Shih-Che ; Chen, I-Yi ; Tsao, Po-Nien ; Shiao, Shin-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c690t-9629b8ef768ccbf96530119f613ebd53b837555655820ec329977502143354003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenosine triphosphatase</topic><topic>Aedes aegypti</topic><topic>Amino acids</topic><topic>Aquatic insects</topic><topic>Biological fertilization</topic><topic>Biology and Life Sciences</topic><topic>Cell proliferation</topic><topic>Cellular signal transduction</topic><topic>Control</topic><topic>Culicidae</topic><topic>Dengue</topic><topic>Dengue fever</topic><topic>Drosophila</topic><topic>Embryogenesis</topic><topic>Fecundity</topic><topic>Fertility</topic><topic>Fertilization</topic><topic>Genetic aspects</topic><topic>Human diseases</topic><topic>Insecticides</topic><topic>Insects</topic><topic>JNK protein</topic><topic>Medicine and Health Sciences</topic><topic>Mosquitoes</topic><topic>Notch protein</topic><topic>Parasitology</topic><topic>Phenotypes</topic><topic>Phosphorylation</topic><topic>Physiological aspects</topic><topic>Product development</topic><topic>Proliferation</topic><topic>Research and Analysis Methods</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Stem cells</topic><topic>Tropical diseases</topic><topic>Vaccines</topic><topic>Vector-borne diseases</topic><topic>Wolbachia</topic><topic>Yellow fever mosquito</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Chia-Hao</creatorcontrib><creatorcontrib>Liu, Yu-Ting</creatorcontrib><creatorcontrib>Weng, Shih-Che</creatorcontrib><creatorcontrib>Chen, I-Yi</creatorcontrib><creatorcontrib>Tsao, Po-Nien</creatorcontrib><creatorcontrib>Shiao, 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Shih-Che</au><au>Chen, I-Yi</au><au>Tsao, Po-Nien</au><au>Shiao, Shin-Hong</au><au>Bartholomay, Lyric C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2018-03-05</date><risdate>2018</risdate><volume>12</volume><issue>3</issue><spage>e0006307</spage><epage>e0006307</epage><pages>e0006307-e0006307</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>The Notch signaling pathway is a highly evolutionarily-conserved cell-cell signaling pathway that regulates many events during development. It plays a pivotal role in the regulation of fundamental cellular processes, such as cell proliferation, stem cell maintenance, and differentiation during embryonic and adult development. However, functions of Notch signaling in Aedes aegypti, the major mosquito vector for dengue, are largely unknown. In this study, we identified a unique feature of A. aegypti Notch (AaNotch) in the control of the sterile-like phenotype in female mosquitoes. Silencing AaNotch with a reverse genetic approach significantly reduced the fecundity and fertility of the mosquito. Silencing AaNotch also resulted in the prevention of micropyle formation, which led to impaired fertilization. In addition, JNK phosphorylation (a signaling molecule in the non-canonical Notch signaling pathway) was inhibited in the absence of AaNotch. Furthermore, treatment with a JNK inhibitor in the mosquito resulted in impaired fecundity and fertility. Taken together, our results demonstrate that non-canonical Notch signaling is essential for controlling fertility in the A. aegypti mosquito.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29505577</pmid><doi>10.1371/journal.pntd.0006307</doi><orcidid>https://orcid.org/0000-0002-7749-7807</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adenosine triphosphatase Aedes aegypti Amino acids Aquatic insects Biological fertilization Biology and Life Sciences Cell proliferation Cellular signal transduction Control Culicidae Dengue Dengue fever Drosophila Embryogenesis Fecundity Fertility Fertilization Genetic aspects Human diseases Insecticides Insects JNK protein Medicine and Health Sciences Mosquitoes Notch protein Parasitology Phenotypes Phosphorylation Physiological aspects Product development Proliferation Research and Analysis Methods Signal transduction Signaling Stem cells Tropical diseases Vaccines Vector-borne diseases Wolbachia Yellow fever mosquito |
title | The non-canonical Notch signaling is essential for the control of fertility in Aedes aegypti |
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