Onchocerca volvulus infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status
Onchocerciasis in Yemen is one of the most neglected diseases, where baseline estimates of onchocerciasis and monitoring of the impact of ivermectin regularly administered to the affected individuals on its transmission are lacking. Therefore, this study aimed to determine the anti-Ov16 IgG4 seropre...
Gespeichert in:
| Veröffentlicht in: | PLoS neglected tropical diseases 2018-03, Vol.12 (3), p.e0006329-e0006329 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e0006329 |
|---|---|
| container_issue | 3 |
| container_start_page | e0006329 |
| container_title | PLoS neglected tropical diseases |
| container_volume | 12 |
| creator | Mahdy, Mohammed A K Abdul-Ghani, Rashad Abdulrahman, Thaker A A Al-Eryani, Samira M A Al-Mekhlafi, Abdulsalam M Alhaidari, Sami A A Azazy, Ahmed A |
| description | Onchocerciasis in Yemen is one of the most neglected diseases, where baseline estimates of onchocerciasis and monitoring of the impact of ivermectin regularly administered to the affected individuals on its transmission are lacking. Therefore, this study aimed to determine the anti-Ov16 IgG4 seroprevalence among local communities of Hodeidah and Al-Mahwit governorates of Tihama region. The factors possibly associated with previous exposure to infection were also studied.
This cross-sectional study was conducted in two ivermectin-targeted districts endemic for onchocerciasis in Hodeidah and Al-Mahwit and two untargeted districts with unknown previous endemicity in Hodeidah between February and July 2017. For 508 residents sampled by a multi-stage random approach, data were collected and blood specimens were screened for anti-Ov16 IgG4 using the SD BIOLINE Onchocerciasis IgG4 rapid tests. The study revealed an overall anti-Ov16 IgG4 rate of 18.5% (94/508) in all surveyed districts, with 10.2% (12/118) of children aged ≤10 years being seropositive. Moreover, rates of 8.0% (4/50) and 6.1% (4/66) were found in districts not officially listed as endemic for the disease. Multivariable analysis confirmed the age of more than ten years and residing within a large family as the independent predictors of exposure to infection.
Onchocerciasis transmission is still ongoing as supported by the higher anti-Ov16 IgG4 seroprevalence rate among children aged ≤10 years compared to that ( |
| doi_str_mv | 10.1371/journal.pntd.0006329 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2025704997</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A533345694</galeid><doaj_id>oai_doaj_org_article_efafaa53f586410689bff7a8ac3a8414</doaj_id><sourcerecordid>A533345694</sourcerecordid><originalsourceid>FETCH-LOGICAL-c624t-35ca5a85b06b2ab3df0ab21acbde014c7850deb2d7b4b8236583e730470e0d53</originalsourceid><addsrcrecordid>eNptU01v1DAQjRCIlsI_QGAJCXHZxYntfPSAVFV8VKrUy144WRNnsuvi2Ivt7Kq_jr-G06aliyofbNnvvRm_mcmytzld5qzKP1-70Vswy62N3ZJSWrKieZYd5w0Ti6Ji4vmj81H2KoRrSkUj6vxldlQ0ggpR0-Psz5VVG6fQKyA7Z3ajGQPRtkcVtbPpRFZ6AwMQj-vpYkH2GCJxPfmJA9pTcu5s1HbUdk2iBxsGHcLM1Dv0wyRkFxH8GiN2BG2Hg1akd0oTsB0Z7Q61-fei483E7XSIXqsYyF7HDdl63Gk3BnOTCL-s21sSIsQxvM5e9GACvpn3k2z17evq_Mfi8ur7xfnZ5UKVBY8LJhQIqEVLy7aAlnU9hbbIQbUd0pyrqha0w7boqpa3dcFKUTOsGOUVRdoJdpK9v5PdGhfkbH2QBS1ERXnTVAlxcYfoHFzLrdcD-BvpQMvbC-fXEnzUyqDEHnoAwXpRlzynZd20fV9BDYpBzXOetL7M0cZ2wE6hTdaaA9HDF6s3cu12UtSCc1YkgU-zgHe_x1Qwmcqi0BiwmFxMeed5UfGqKhP0w3_Qp383o9aQPpD6w6W4ahKVZ4IxxkXZTHkvn0CldVtZZ7FPlT4kfHxE2CCYuAnOjFPvhUMgvwMq70Lw2D-YkVM5jcN91nIaBzmPQ6K9e2zkA-m-_9lf0UgM7Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2025704997</pqid></control><display><type>article</type><title>Onchocerca volvulus infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status</title><source>PLoS</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Mahdy, Mohammed A K ; Abdul-Ghani, Rashad ; Abdulrahman, Thaker A A ; Al-Eryani, Samira M A ; Al-Mekhlafi, Abdulsalam M ; Alhaidari, Sami A A ; Azazy, Ahmed A</creator><contributor>French, Michael</contributor><creatorcontrib>Mahdy, Mohammed A K ; Abdul-Ghani, Rashad ; Abdulrahman, Thaker A A ; Al-Eryani, Samira M A ; Al-Mekhlafi, Abdulsalam M ; Alhaidari, Sami A A ; Azazy, Ahmed A ; French, Michael</creatorcontrib><description>Onchocerciasis in Yemen is one of the most neglected diseases, where baseline estimates of onchocerciasis and monitoring of the impact of ivermectin regularly administered to the affected individuals on its transmission are lacking. Therefore, this study aimed to determine the anti-Ov16 IgG4 seroprevalence among local communities of Hodeidah and Al-Mahwit governorates of Tihama region. The factors possibly associated with previous exposure to infection were also studied.
This cross-sectional study was conducted in two ivermectin-targeted districts endemic for onchocerciasis in Hodeidah and Al-Mahwit and two untargeted districts with unknown previous endemicity in Hodeidah between February and July 2017. For 508 residents sampled by a multi-stage random approach, data were collected and blood specimens were screened for anti-Ov16 IgG4 using the SD BIOLINE Onchocerciasis IgG4 rapid tests. The study revealed an overall anti-Ov16 IgG4 rate of 18.5% (94/508) in all surveyed districts, with 10.2% (12/118) of children aged ≤10 years being seropositive. Moreover, rates of 8.0% (4/50) and 6.1% (4/66) were found in districts not officially listed as endemic for the disease. Multivariable analysis confirmed the age of more than ten years and residing within a large family as the independent predictors of exposure to infection.
Onchocerciasis transmission is still ongoing as supported by the higher anti-Ov16 IgG4 seroprevalence rate among children aged ≤10 years compared to that (<0.1%) previously set by the World Health Organization as a serologic criterion for transmission interruption. Further large-scale studies combining serologic and entomologic criteria are recommended for the mapping of O. volvulus in human and blackfly populations in endemic foci and their neighboring areas of uncertain endemicity. In addition, ivermectin distribution, coverage and impact on disease transmission need to be continually assessed.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0006329</identifier><identifier>PMID: 29505580</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Children ; Decision making ; Demographic aspects ; Disease transmission ; Dosage and administration ; Drug therapy ; Endemic species ; Endemism ; Exposure ; Funding ; Health sciences ; Immunoglobulin G ; Infections ; Ivermectin ; Local communities ; Medicine ; Medicine and Health Sciences ; Onchocerca volvulus ; Onchocerciasis ; Organizations ; Parasitology ; People and Places ; Risk factors ; Serology ; Simulium ; Social Sciences ; Transmission ; Tropical diseases</subject><ispartof>PLoS neglected tropical diseases, 2018-03, Vol.12 (3), p.e0006329-e0006329</ispartof><rights>COPYRIGHT 2018 Public Library of Science</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status. PLoS Negl Trop Dis 12(3): e0006329. https://doi.org/10.1371/journal.pntd.0006329</rights><rights>2018 Mahdy et al 2018 Mahdy et al</rights><rights>2018 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status. PLoS Negl Trop Dis 12(3): e0006329. https://doi.org/10.1371/journal.pntd.0006329</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-35ca5a85b06b2ab3df0ab21acbde014c7850deb2d7b4b8236583e730470e0d53</citedby><cites>FETCH-LOGICAL-c624t-35ca5a85b06b2ab3df0ab21acbde014c7850deb2d7b4b8236583e730470e0d53</cites><orcidid>0000-0002-8340-5219</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854432/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854432/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29505580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>French, Michael</contributor><creatorcontrib>Mahdy, Mohammed A K</creatorcontrib><creatorcontrib>Abdul-Ghani, Rashad</creatorcontrib><creatorcontrib>Abdulrahman, Thaker A A</creatorcontrib><creatorcontrib>Al-Eryani, Samira M A</creatorcontrib><creatorcontrib>Al-Mekhlafi, Abdulsalam M</creatorcontrib><creatorcontrib>Alhaidari, Sami A A</creatorcontrib><creatorcontrib>Azazy, Ahmed A</creatorcontrib><title>Onchocerca volvulus infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Onchocerciasis in Yemen is one of the most neglected diseases, where baseline estimates of onchocerciasis and monitoring of the impact of ivermectin regularly administered to the affected individuals on its transmission are lacking. Therefore, this study aimed to determine the anti-Ov16 IgG4 seroprevalence among local communities of Hodeidah and Al-Mahwit governorates of Tihama region. The factors possibly associated with previous exposure to infection were also studied.
This cross-sectional study was conducted in two ivermectin-targeted districts endemic for onchocerciasis in Hodeidah and Al-Mahwit and two untargeted districts with unknown previous endemicity in Hodeidah between February and July 2017. For 508 residents sampled by a multi-stage random approach, data were collected and blood specimens were screened for anti-Ov16 IgG4 using the SD BIOLINE Onchocerciasis IgG4 rapid tests. The study revealed an overall anti-Ov16 IgG4 rate of 18.5% (94/508) in all surveyed districts, with 10.2% (12/118) of children aged ≤10 years being seropositive. Moreover, rates of 8.0% (4/50) and 6.1% (4/66) were found in districts not officially listed as endemic for the disease. Multivariable analysis confirmed the age of more than ten years and residing within a large family as the independent predictors of exposure to infection.
Onchocerciasis transmission is still ongoing as supported by the higher anti-Ov16 IgG4 seroprevalence rate among children aged ≤10 years compared to that (<0.1%) previously set by the World Health Organization as a serologic criterion for transmission interruption. Further large-scale studies combining serologic and entomologic criteria are recommended for the mapping of O. volvulus in human and blackfly populations in endemic foci and their neighboring areas of uncertain endemicity. In addition, ivermectin distribution, coverage and impact on disease transmission need to be continually assessed.</description><subject>Biology and Life Sciences</subject><subject>Children</subject><subject>Decision making</subject><subject>Demographic aspects</subject><subject>Disease transmission</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Endemic species</subject><subject>Endemism</subject><subject>Exposure</subject><subject>Funding</subject><subject>Health sciences</subject><subject>Immunoglobulin G</subject><subject>Infections</subject><subject>Ivermectin</subject><subject>Local communities</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Onchocerca volvulus</subject><subject>Onchocerciasis</subject><subject>Organizations</subject><subject>Parasitology</subject><subject>People and Places</subject><subject>Risk factors</subject><subject>Serology</subject><subject>Simulium</subject><subject>Social Sciences</subject><subject>Transmission</subject><subject>Tropical diseases</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNptU01v1DAQjRCIlsI_QGAJCXHZxYntfPSAVFV8VKrUy144WRNnsuvi2Ivt7Kq_jr-G06aliyofbNnvvRm_mcmytzld5qzKP1-70Vswy62N3ZJSWrKieZYd5w0Ti6Ji4vmj81H2KoRrSkUj6vxldlQ0ggpR0-Psz5VVG6fQKyA7Z3ajGQPRtkcVtbPpRFZ6AwMQj-vpYkH2GCJxPfmJA9pTcu5s1HbUdk2iBxsGHcLM1Dv0wyRkFxH8GiN2BG2Hg1akd0oTsB0Z7Q61-fei483E7XSIXqsYyF7HDdl63Gk3BnOTCL-s21sSIsQxvM5e9GACvpn3k2z17evq_Mfi8ur7xfnZ5UKVBY8LJhQIqEVLy7aAlnU9hbbIQbUd0pyrqha0w7boqpa3dcFKUTOsGOUVRdoJdpK9v5PdGhfkbH2QBS1ERXnTVAlxcYfoHFzLrdcD-BvpQMvbC-fXEnzUyqDEHnoAwXpRlzynZd20fV9BDYpBzXOetL7M0cZ2wE6hTdaaA9HDF6s3cu12UtSCc1YkgU-zgHe_x1Qwmcqi0BiwmFxMeed5UfGqKhP0w3_Qp383o9aQPpD6w6W4ahKVZ4IxxkXZTHkvn0CldVtZZ7FPlT4kfHxE2CCYuAnOjFPvhUMgvwMq70Lw2D-YkVM5jcN91nIaBzmPQ6K9e2zkA-m-_9lf0UgM7Q</recordid><startdate>20180305</startdate><enddate>20180305</enddate><creator>Mahdy, Mohammed A K</creator><creator>Abdul-Ghani, Rashad</creator><creator>Abdulrahman, Thaker A A</creator><creator>Al-Eryani, Samira M A</creator><creator>Al-Mekhlafi, Abdulsalam M</creator><creator>Alhaidari, Sami A A</creator><creator>Azazy, Ahmed A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8340-5219</orcidid></search><sort><creationdate>20180305</creationdate><title>Onchocerca volvulus infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status</title><author>Mahdy, Mohammed A K ; Abdul-Ghani, Rashad ; Abdulrahman, Thaker A A ; Al-Eryani, Samira M A ; Al-Mekhlafi, Abdulsalam M ; Alhaidari, Sami A A ; Azazy, Ahmed A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-35ca5a85b06b2ab3df0ab21acbde014c7850deb2d7b4b8236583e730470e0d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biology and Life Sciences</topic><topic>Children</topic><topic>Decision making</topic><topic>Demographic aspects</topic><topic>Disease transmission</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Endemic species</topic><topic>Endemism</topic><topic>Exposure</topic><topic>Funding</topic><topic>Health sciences</topic><topic>Immunoglobulin G</topic><topic>Infections</topic><topic>Ivermectin</topic><topic>Local communities</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Onchocerca volvulus</topic><topic>Onchocerciasis</topic><topic>Organizations</topic><topic>Parasitology</topic><topic>People and Places</topic><topic>Risk factors</topic><topic>Serology</topic><topic>Simulium</topic><topic>Social Sciences</topic><topic>Transmission</topic><topic>Tropical diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahdy, Mohammed A K</creatorcontrib><creatorcontrib>Abdul-Ghani, Rashad</creatorcontrib><creatorcontrib>Abdulrahman, Thaker A A</creatorcontrib><creatorcontrib>Al-Eryani, Samira M A</creatorcontrib><creatorcontrib>Al-Mekhlafi, Abdulsalam M</creatorcontrib><creatorcontrib>Alhaidari, Sami A A</creatorcontrib><creatorcontrib>Azazy, Ahmed A</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahdy, Mohammed A K</au><au>Abdul-Ghani, Rashad</au><au>Abdulrahman, Thaker A A</au><au>Al-Eryani, Samira M A</au><au>Al-Mekhlafi, Abdulsalam M</au><au>Alhaidari, Sami A A</au><au>Azazy, Ahmed A</au><au>French, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Onchocerca volvulus infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2018-03-05</date><risdate>2018</risdate><volume>12</volume><issue>3</issue><spage>e0006329</spage><epage>e0006329</epage><pages>e0006329-e0006329</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Onchocerciasis in Yemen is one of the most neglected diseases, where baseline estimates of onchocerciasis and monitoring of the impact of ivermectin regularly administered to the affected individuals on its transmission are lacking. Therefore, this study aimed to determine the anti-Ov16 IgG4 seroprevalence among local communities of Hodeidah and Al-Mahwit governorates of Tihama region. The factors possibly associated with previous exposure to infection were also studied.
This cross-sectional study was conducted in two ivermectin-targeted districts endemic for onchocerciasis in Hodeidah and Al-Mahwit and two untargeted districts with unknown previous endemicity in Hodeidah between February and July 2017. For 508 residents sampled by a multi-stage random approach, data were collected and blood specimens were screened for anti-Ov16 IgG4 using the SD BIOLINE Onchocerciasis IgG4 rapid tests. The study revealed an overall anti-Ov16 IgG4 rate of 18.5% (94/508) in all surveyed districts, with 10.2% (12/118) of children aged ≤10 years being seropositive. Moreover, rates of 8.0% (4/50) and 6.1% (4/66) were found in districts not officially listed as endemic for the disease. Multivariable analysis confirmed the age of more than ten years and residing within a large family as the independent predictors of exposure to infection.
Onchocerciasis transmission is still ongoing as supported by the higher anti-Ov16 IgG4 seroprevalence rate among children aged ≤10 years compared to that (<0.1%) previously set by the World Health Organization as a serologic criterion for transmission interruption. Further large-scale studies combining serologic and entomologic criteria are recommended for the mapping of O. volvulus in human and blackfly populations in endemic foci and their neighboring areas of uncertain endemicity. In addition, ivermectin distribution, coverage and impact on disease transmission need to be continually assessed.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>29505580</pmid><doi>10.1371/journal.pntd.0006329</doi><orcidid>https://orcid.org/0000-0002-8340-5219</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2018-03, Vol.12 (3), p.e0006329-e0006329 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2025704997 |
| source | PLoS; DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Biology and Life Sciences Children Decision making Demographic aspects Disease transmission Dosage and administration Drug therapy Endemic species Endemism Exposure Funding Health sciences Immunoglobulin G Infections Ivermectin Local communities Medicine Medicine and Health Sciences Onchocerca volvulus Onchocerciasis Organizations Parasitology People and Places Risk factors Serology Simulium Social Sciences Transmission Tropical diseases |
| title | Onchocerca volvulus infection in Tihama region - west of Yemen: Continuing transmission in ivermectin-targeted endemic foci and unveiled endemicity in districts with previously unknown status |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T18%3A45%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Onchocerca%20volvulus%20infection%20in%20Tihama%20region%20-%20west%20of%20Yemen:%20Continuing%20transmission%20in%20ivermectin-targeted%20endemic%20foci%20and%20unveiled%20endemicity%20in%20districts%20with%20previously%20unknown%20status&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Mahdy,%20Mohammed%20A%20K&rft.date=2018-03-05&rft.volume=12&rft.issue=3&rft.spage=e0006329&rft.epage=e0006329&rft.pages=e0006329-e0006329&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0006329&rft_dat=%3Cgale_plos_%3EA533345694%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2025704997&rft_id=info:pmid/29505580&rft_galeid=A533345694&rft_doaj_id=oai_doaj_org_article_efafaa53f586410689bff7a8ac3a8414&rfr_iscdi=true |